Results 271 to 280 of about 1,168,781 (390)

Adiponectin Assists Thrombopoietic Agents in ITP Treatment by Enhancing Myosin‐9/Rab6A‐Mediated Trafficking of c‐Mpl in MKs

Advanced Science, EarlyView.
This study revealed that adiponectin facilitates the therapeutic efficiency of thrombopoietic agents by stimulating the membrane trafficking of c‐Mpl in MKs, which provides a point for ITP therapy. Moreover, a novel c‐Mpl trafficking mechanism based on the Myosin‐9/Rab6A complex is constructed. These findings provide new insights into the applicability
Xin Zhao, Huixian Ma, Guosheng Li, Jilong Xiao, Zhiyu Shi, Mingying Li, Xinguang Liu, Tao Sun, Chunyan Ji   +8 more
wiley   +1 more source

Estimation of Dopamine D₁ Receptor Agonist Binding Kinetics Using Time-Resolved Functional Assays: Relation to Agonist-Induced Receptor Internalization by Investigational Antiparkinsonian Therapeutics. [PDF]

ACS Chem Neurosci
Sahlholm K, Svensson P, Malo M, Andersson DR, Betari N.   +4 more
europepmc   +1 more source

A dual action of muscarinic partial agonists on pupil size of rabbit.

, 1982
ETSUKO TERASHIMA, Issei Takayanagi, Mitsuo Ohashi   +2 more
openalex   +2 more sources

A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport

Proceedings of the National Academy of Sciences of the United States of America, 2001
W. Oliver, J. L. Shenk, Mike R. Snaith, Caroline Russell, K. D. Plunket, N. Bodkin, M. Lewis, D. Winegar, Marcos L. Sznaidman, Millard H. Lambert, H. Xu, Daniel D. Sternbach, S. Kliewer, B. Hansen, Timothy M. Willson   +14 more
semanticscholar   +1 more source

The Multitarget Compound ZLY032 Achieves Treatment of Chronic Wounds

Advanced Science, EarlyView.
ZLY032, a dual free fatty acid receptor 1/peroxisome proliferator‐activated receptor δ agonist, accelerates wound healing in normal/diabetic/methicillin‐resistant Staphylococcus aureus‐infected models by promoting angiogenesis, reducing inflammation, and exhibiting antibacterial activity via argininosuccinate lyase targeting, with demonstrated efficacy
Manyu Gong, Zhiyuan Du, Tiantian Gong, Yu Wang, Chenchen Yin, Bosi Sun, Zijia Liu, Lianru Chen, Zibin Liao, Wenxin Wang, Tianjiao Zhao, Yifei Wang, Ying Dong, Kexin Wang, Mengru Ma, Weijun Li, Jiacheng Li, Haodong Li, Congcong Lin, Ying Zhang, Yu Liu, Xin Liu, Tao Ban, Hongxia Bao, Ying Zhang, Yang Zhang, Zheng Li, Lei Jiao   +27 more
wiley   +1 more source

Non-canonical G_q activation by orexin receptor type 2 and lemborexant observed in microsecond molecular dynamics simulations. [PDF]

Sci Rep
Dragan P, Gratio V, Voisin T, Couvineau A, Latek D.   +4 more
europepmc   +1 more source

EXCITATORY RESPONSE TO α-ADRENOCEPTOR AGONIST ON CONTRACTIONS OF ISOLATED RABBIT SPHINCTER OF ODDI AND DUODENUM

, 1983
Kenji YAMADA, Motohiro IIZUKA
openalex   +2 more sources

Association of opioid agonist therapy with lower incidence of hepatitis C virus infection in young adult injection drug users.

JAMA Internal Medicine, 2014
J. Tsui, J. Evans, Paula J Lum, J. Hahn, K. Page   +4 more
semanticscholar   +1 more source

USP45 Represses Melanoma Development by Deubiquitinating and Stabilizing Tumor Suppressor MRGPRF

Advanced Science, EarlyView.
USP45 acts as a melanoma suppressor by stabilizing MRGPRF, which weakens the PI3K/AKT pathway, suppresses tumor growth, and reduces melanoma cell migration and invasion. Abstract Melanoma, a highly malignant skin cancer, has seen a rising incidence and death toll. MRGPRF is a novel melanoma suppressor that inhibits the PI3K/AKT pathway.
Wancong Zhang, Liyun Chen, Jing Zhao, Aiwei Ma, Wenqi Shi, Yiwen Zhang, Zixuan Tang, Jiarui Guo, Zaihua Xu, Jianda Zhou, Shijie Tang   +10 more
wiley   +1 more source

The Double-Edged Nature of the Gonadotropin-Releasing Hormone Agonist (GnRHa) Long Protocol: A Case of Paradoxical Ovarian Hyperstimulation During the Expected Downregulation Phase. [PDF]

J Clin Med
Nádasdi B, Kovács P, Csajbók ÉA, Wellinger K, Vágvölgyi A, Zádori J.   +5 more
europepmc   +1 more source