Results 291 to 300 of about 1,200,697 (382)

A simple method for quantifying functional selectivity and agonist bias.

ACS Chemical Neuroscience, 2012
T. Kenakin, C. Watson, Vanessa M. Muniz-Medina, A. Christopoulos, Steven J Novick   +4 more
semanticscholar   +1 more source

ARL3 Enhances ERα Stability via USP10 Deubiquitination to Promote Endocrine Resistance and Drive Mitochondrial Metabolic Reprogramming in HR+ Breast Cancer

Advanced Science, EarlyView.
This study identifies ADP‐ribosylation factor‐like protein 3 (ARL3) as a novel chaperone that stabilizes estrogen receptor α (ERα) in breast cancer. ARL3 promotes tumor growth by recruiting USP10 to remove ubiquitin chains from ERα, preventing its degradation.
Han Li, Yang Liu, Zehao Cai, Kang Li, Shun Gao, Ailin Lan, Dan Shu, Kuan He, Xin Liu, Yang Peng, Shipeng Guo, Haochen Yu, Aishun Jin, Meiying Shen, Shengchun Liu   +14 more
wiley   +1 more source

MC1R determines healing outcomes in acute and chronic cutaneous wounds. [PDF]

Proc Natl Acad Sci U S A
Nawilaijaroen Y, Rocliffe HR, Austin-Williams S, Krilis G, Dawson C, Harijanto P, Pellicoro A, Zhou K, Ji Y, Bain CA, Kilpatrick AM, Chen Y, Biswas A, Forbes S, Crichton M, Huang Z, Forbes SJ, Caporali A, Cash JL.   +18 more
europepmc   +1 more source

Pressurised metered dose inhalers versus all other hand-held inhaler devices to deliver beta-2 agonist bronchodilators for non-acute asthma

, 2002
Felix SF Ram, D. Brocklebank, John White, John Wright, Paul Jones   +4 more
openalex   +2 more sources

Integrin‐Piezo1 Axis Drives ECM Remodeling and Invasion of 3D Breast Epithelium

Advanced Science, EarlyView.
Mechanical stiffening of the extracellular matrix around mature mammary acini induces sequential remodeling phases. An early response disrupts the basement membrane and promotes fibronectin secretion, followed by delayed invasion with matrix reorganization and proliferation.
Kabilan Sakthivel, Anna Kotowska, Zhimeng Fan, Ellen Juel Portner, Catherine Merry, Pontus Nordenfelt, Adam Cohen Simonsen, Amanda J. Wright, Vinay S Swaminathan   +8 more
wiley   +1 more source

Identification of anti-mouse PD-1 agonist antibodies that inhibit T cell activation. [PDF]

Front Immunol
Liu L, Takashima S, Tokumaru Y, Ikuta N, Nakajima Y, Ohta A.   +5 more
europepmc   +1 more source

Structure of the ligand‐binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist

EMBO Journal, 1999
A. Pike, A. Brzozowski, R. Hubbard, T. Bonn, A. Thorsell, O. Engström, J. Ljunggren, J. Gustafsson, M. Carlquist   +8 more
semanticscholar   +1 more source

Heat Stress Modulates WDR5‐Mediated H3K4me3 Modification to Induce Melanogenesis via Activating CX3CL1/CX3CR1 Axis

Advanced Science, EarlyView.
This study elucidates the mechanism by which heat stress regulates skin pigmentation: heat stress upregulates CX3CL1 through the MYC‐WDR5‐H3K4me3 axis, thereby activating the CX3CL1/CX3CR1‐JNK signaling pathway and ultimately promoting melanogenesis. These findings provide novel potential therapeutic targets for pigmentary skin disorders.
Yushan Zhang, Ling Jiang, Yibo Hu, Chuhan Fu, Jinhua Huang, Jing Chen, Qinghai Zeng   +6 more
wiley   +1 more source

Cannabinoid 1 receptor occupancy and neurovascular responses induced by agonist, antagonist/inverse-agonist, and potential modulator in non-human primate brains: PET/fMRI study. [PDF]

J Cereb Blood Flow Metab
Yoo CH, Xu Y, Bagdasarian FA, Lin YS, Wang C, Wey HY.   +5 more
europepmc   +1 more source

Design and synthesis of N6-substituted-4′-thioadenosine-5′-uronamides as potent and selective human A3 adenosine receptor agonists

, 2009
Won Jun Choi, Hyuk Woo Lee, Hea Ok Kim, Moshe Chinn, Zhan‐Guo Gao, Amit R. Patel, Kenneth A. Jacobson, Hyung Ryong Moon, Young Hoon Jung, Lak Shin Jeong   +9 more
openalex   +1 more source