Results 311 to 320 of about 847,478 (341)
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Specific GABAA agonists and partial agonists
The Chemical Record, 2002AbstractThe GABAA receptor system is implicated in a number of neurological and psychiatric diseases, making GABAA receptor ligands interesting as potential therapeutic agents. Only a few different classes of structures are currently known as ligands for the GABA recognition site on the hetero‐pentameric GABAA receptor complex, reflecting the very ...
Krogsgaard-Larsen, Povl +2 more
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Agonist ist nicht gleich Agonist [PDF]
Chemie in unserer Zeit, 2008 AbstractVerschiedene Liganden ein‐ und desselben Rezeptors können unterschiedliche Wirkungen auslösen, sie zeigen funktionelle Selektivität. So wirken einige, aber nicht alle Agonisten des Typ2A‐Serotoninrezeptors halluzinogen. Das liegt offenbar an der Komplexität des vom Rezeptor gesteuerten Netzwerks der Signaltransduktion.
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Agonists, partial agonists, antagonists, inverse agonists and agonist/antagonists?
Trends in Pharmacological Sciences, 1987The label placed on a drug influences its ultimate use. But interpretation ofin-vivo data has complicated the simple receptor theory of agonists and antagonists for certain classes of drugs.Terry Kenakin argues that clarification of such data — described in an extremely complex system — at a molecular level, will either obviate the need for terms such ...
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Seminars in Neurology, 2001
Dopamine agonists provide an effective means of treating early, middle, and late stages of Parkinson's disease. This article outlines the advantages and disadvantages of dopamine agonists as compared with levodopa therapy. The features and costs of the four Food and Drug Administration-approved agonists (bromocriptine, pergolide, pramipexole, and ...
P, Tuite, B, Ebbitt
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Dopamine agonists provide an effective means of treating early, middle, and late stages of Parkinson's disease. This article outlines the advantages and disadvantages of dopamine agonists as compared with levodopa therapy. The features and costs of the four Food and Drug Administration-approved agonists (bromocriptine, pergolide, pramipexole, and ...
P, Tuite, B, Ebbitt
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Cellular and Molecular Neurobiology, 2019
Trace amine-associated receptors (TAARs) are a family of G protein-coupled receptors (GPCRs) that are evolutionarily conserved in vertebrates. The first discovered TAAR1 is mainly expressed in the brain, and is able to detect low abundant trace amines.
Zhengrong Xu, Qian Li
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Trace amine-associated receptors (TAARs) are a family of G protein-coupled receptors (GPCRs) that are evolutionarily conserved in vertebrates. The first discovered TAAR1 is mainly expressed in the brain, and is able to detect low abundant trace amines.
Zhengrong Xu, Qian Li
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2016
Cannabis has been used by humans since ancient history, but it was not until the 1960s, with the isolation of Δ9-tetrahydrocannabinol (Δ9-THC), that research with cannabinoids took off. One of the most important findings was the discovery of the endocannabinoid system; this system is formed by the cannabinoid receptors, endogenous ligands of these ...
Bagues, Ana, Goicoechea, Carlos
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Cannabis has been used by humans since ancient history, but it was not until the 1960s, with the isolation of Δ9-tetrahydrocannabinol (Δ9-THC), that research with cannabinoids took off. One of the most important findings was the discovery of the endocannabinoid system; this system is formed by the cannabinoid receptors, endogenous ligands of these ...
Bagues, Ana, Goicoechea, Carlos
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Medical Clinics of North America, 1999
Dopamine agonists have been used in the treatment of Parkinson's disease (PD) since the mid 1970s. With the approval of two new agents in 1997, the number available in the United States is up to four; bromocriptine, pergolide, pramipexole, ropinirole.
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Dopamine agonists have been used in the treatment of Parkinson's disease (PD) since the mid 1970s. With the approval of two new agents in 1997, the number available in the United States is up to four; bromocriptine, pergolide, pramipexole, ropinirole.
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Annals of Internal Medicine, 1996
Considerable evidence links elevated blood cholesterol levels to the development of atherosclerosis. The National Cholesterol Education Program (NCEP) has recently published revised guidelines for detecting and treating hypercholesterolemia in adults.
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Considerable evidence links elevated blood cholesterol levels to the development of atherosclerosis. The National Cholesterol Education Program (NCEP) has recently published revised guidelines for detecting and treating hypercholesterolemia in adults.
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The Journal of Pharmacology and Experimental Therapeutics, 1984
Using an extensively washed membrane preparation and standardized incubation conditions, the actions of benzodiazepine (BZ) receptor ligands were evaluated on [3H]flunitrazepam [+/- 10 microM gamma-aminobutyric acid (GABA)], [3H]muscimol (+/- 2.5 microM etazolate) and [35S]butyl bicyclophosphorothionate (TBPS) binding.
P L, Wood +4 more
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Using an extensively washed membrane preparation and standardized incubation conditions, the actions of benzodiazepine (BZ) receptor ligands were evaluated on [3H]flunitrazepam [+/- 10 microM gamma-aminobutyric acid (GABA)], [3H]muscimol (+/- 2.5 microM etazolate) and [35S]butyl bicyclophosphorothionate (TBPS) binding.
P L, Wood +4 more
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An Agonistic Model of Dialogue
Journal of Constructivist Psychology, 2017In this article, Schellhammer's statements that learning is only possible in tension and that difference and diversity are prerequisites for tension are discussed in light of a certain event that o...
Suransky, A. C., Alma, H. A.
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