Results 321 to 330 of about 847,478 (341)

Melatonin agonists and insomnia

Expert Review of Neurotherapeutics, 2010
The ability of melatonin to shift biological rhythms is well known. As a result, melatonin has been used in the treatment of various circadian rhythm sleep disorders, such as advanced and delayed sleep phase disorders, jet lag and shiftwork disorder.
Ferguson, Sally A, Rajaratnam, S, Dawson, Drew   +2 more
openaire   +5 more sources

GnRH Agonists

Clinical Obstetrics and Gynecology, 1989
The development of GnRH agonists has had a major impact on the practice of gynecology and reproductive endocrinology. The clinical usefulness of GnRH agonists will increase as modes of administration are improved and indications become better defined. GnRH agonists and, potentially, antagonists will provide a prompt, effective, and reversible method of
openaire   +2 more sources

GABAA Receptor Agonists, Partial Agonists, and Antagonists

1997
The neutral amino acid, γ-aminobutyric acid (GABA), is an inhibitory transmitter in the central nervous system (CNS). Furthermore, GABA is involved as a neurotransmitter and/or a paracrine effector in the regulation of a variety of physiological mechanisms in the periphery.
Frølund, Bente, Krogsgaard-Larsen, Povl, Ebert, Bjarke   +2 more
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Neuroprotection by dopamine agonists

Journal of neural transmission. Supplementum, 1994
Research on Parkinson's disease has led to new hypotheses concerning the mechanisms of neurodegeneration and to the development of neuroprotective agents. Recent findings of impaired mitochondrial function, altered iron metabolism and increased lipid peroxidation in the substantia nigra of parkinsonian patients emphasize the significance of oxidative ...
Lange, Klaus W., Rausch, W. D., Gsell, W., Naumann, M., Oestreicher, E., Riederer, P.   +5 more
openaire   +4 more sources

Discrimination between Olfactory Receptor Agonists and Non‐agonists

Chemistry – A European Journal, 2014
AbstractA joint approach combining free‐energy calculations and calcium‐imaging assays on the broadly tuned human 1G1 olfactory receptor is reported. The free energy of binding of ten odorants was computed by means of molecular‐dynamics simulations.
Jérôme Golebiowski, Landry Charlier, Jérémie Topin, Serge Antonczak, Catherine Ronin, Claire A. de March   +5 more
openaire   +3 more sources

Partial agonists, full agonists, antagonists: dilemmas of definition

Trends in Pharmacological Sciences, 1993
The absence of selective antagonists makes receptor characterization difficult, and largely dependent on the use of agonists. However, there has been considerable debate as to whether certain drugs acting at G protein-coupled receptors are better described as agonists, partial agonists or antagonists. Indeed many agonists tend to display differences in
Hendrikus Boddeke, Daniel Hoyer
openaire   +3 more sources

Calcium agonists in hyperparathyroidism

Expert Opinion on Investigational Drugs, 2004
Primary hyperparathyroidism (PHPT), in addition to cancer, represents an important cause of hypercalcaemia in the general population. Furthermore, hypercalcaemia, in the course of uraemic HPT, represents the late stage of chronic renal failure refractory to therapy.
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Beta Adrenergic Agonists

CHEST Journal, 1982
eta adrenergic agonists and theophylline are the nucleotide-sensitive regulator protein occurs. This -‘-‘ principal bronchodilators employed in the treatcombination then activates the third component, adement of bronchial asthma. During the last decade, the nylate cyclase, which converts ATP to cyclic clinical usefulness of theophylline has been ...
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EP4 agonist

American Journal of Orthodontics and Dentofacial Orthopedics, 2008
Sumit, Gandhi, Suruchi, Jain, Ashima, Valiathan   +2 more
openaire   +2 more sources

β2-Agonists

Medicine, 2003
openaire   +1 more source