Results 31 to 40 of about 833,545 (343)

Beta-agonist stimulation ameliorates the phenotype of spinal and bulbar muscular atrophy mice and patient-derived myotubes [PDF]

, 2017
Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease characterized by the loss of lower motor neurons. SBMA is caused by expansions of a polyglutamine tract in the gene coding for androgen receptor (AR).
Blaauw, Bert, Borgia, Doriana, Gomes Pereira, Marcelo, Lieberman, Andrew P., Maino, Eleonora, Malena, Adriana, Marchioretti, Caterina, Milioto, Carmelo, Pegoraro, Elena, Pennuto, Maria, Pennuto, Maria, Plebani, Mario, Polanco, Maria J., Sambataro, Fabio, Sambataro, Fabio, Sorar, Gianni, Soraru', Gianni, Venturini, Roberta, Vergani, Lodovica   +18 more
core   +3 more sources

Beta-Adrenergic Agonists [PDF]

Pharmaceuticals, 2010
Inhaled β2-adrenoceptor (β2-AR) agonists are considered essential bronchodilator drugs in the treatment of bronchial asthma, both as symptoms-relievers and, in combination with inhaled corticosteroids, as disease-controllers. In this article, we first review the basic mechanisms by which the β2-adrenergic system contributes to the control of airway ...
Giovanni Barisione, BAROFFIO, MICHELE, CRIMI, EMANUELE, BRUSASCO, VITO   +3 more
openaire   +3 more sources

The mechanics of agonistic muscles [PDF]

Journal of Biomechanics, 2018
In this study, we tested two assumptions that have been made in experimental studies on muscle mechanics: (i) that the torque-angle properties are similar among agonistic muscles crossing a joint, and (ii) that the sum of the torque capacity of individual muscles adds up to the torque capacity of the agonist group.
Heiliane de Brito Fontana, Heiliane de Brito Fontana, Andrew Sawatsky, Walter Herzog, Seong-won Han   +4 more
openaire   +3 more sources

Effects of methimepip and JNJ-5207852 in Wistar rats exposed to an open-field with and without object and in Balb/c mice exposed to a radial-arm maze [PDF]

, 2012
The role of the histamine H3 receptor (H3R) in anxiety is controversial, due to limitations in drug selectivity and limited validity of behavioral tests used in previous studies. In the present report, we describe two experiments.
Abuhamdah, Rushdie M., Chazot, Paul L., Ennaceur, Abdelkader, Lethbridge, Natasha L., van Rensburg, Ruan   +4 more
core   +1 more source

Agonists and Partial Agonists of Rhodopsin:  Retinals with Ring Modifications [PDF]

Biochemistry, 2005
Activation of the visual pigment rhodopsin is initiated by isomerization of its retinal chromophore to the all-trans geometry, which drives the conformation of the protein to the active state. We have examined by FTIR spectroscopy the impact of a series of modifications at the ring of retinal on the activation process and on molecular interactions ...
Vogel, Reiner, Siebert, Friedrich, Lüdeke, Steffen, Hirshfeld, Amiram, Sheves, Mordechai   +4 more
openaire   +4 more sources

TLRs as a Promise Target Along With Immune Checkpoint Against Gastric Cancer

Frontiers in Cell and Developmental Biology, 2021
Gastric cancer (GC) is one of the most common cancers in the world, and the incidence of gastric cancer in Asia appears to increase in recent years. Although there is a lot of improvement in treatment approaches, the prognosis of GC is poor.
Lin Cui, Xiuqing Wang, Dekai Zhang
doaj   +1 more source

Probing the role of the cation–π interaction in the binding sites of GPCRs using unnatural amino acids [PDF]

, 2009
We describe a general application of the nonsense suppression methodology for unnatural amino acid incorporation to probe drug–receptor interactions in functional G protein-coupled receptors (GPCRs), evaluating the binding sites of both the M2 muscarinic
Ballesteros, Cho, D. A. Dougherty, Dougherty, Dougherty, Dougherty, Doupnik, Gallivan, H. A. Lester, Hibert, Hopkins, Huang, Huang, K. S. Bower, Klabunde, Kofuji, Krapivinsky, Lagerstrom, Lu, Lu, M. M. Torrice, Ma, Mark, Nemeth, Nowak, Palczewski, Rasmussen, Schwartz, Warne, Xiu, Zacharias, Zhong   +31 more
core   +3 more sources

The Vitamin Riboflavin and Its Derivative Lumichrome Activate the LasR Bacterial Quorum-Sensing Receptor

Molecular Plant-Microbe Interactions, 2008
Many bacteria use quorum sensing (QS) as an intercellular signaling mechanism to regulate gene expression in local populations. Plant and algal hosts, in turn, secrete compounds that mimic bacterial QS signals, allowing these hosts to manipulate QS ...
Sathish Rajamani, Wolfgang D. Bauer, Jayne B. Robinson, John M. Farrow, Everett C. Pesci, Max Teplitski, Mengsheng Gao, Richard T. Sayre, Donald A. Phillips   +8 more
doaj   +1 more source

Binding and functional structure-activity similarities of 4-substituted 2,5-dimethoxyphenyl isopropylamine analogues at 5-HT2A and 5-HT2B serotonin receptors

Frontiers in Pharmacology, 2023
Certain 4-substituted analogs of 1-(2,5-dimethoxyphenyl)isopropylamine (2,5-DMA) are psychoactive classical hallucinogens or serotonergic psychedelic agents that function as human 5-HT2A (h5-HT2A) serotonin receptor agonists.
Prithvi Hemanth, Pallavi Nistala, Vy T. Nguyen, Jose M. Eltit, Richard A. Glennon, Małgorzata Dukat   +5 more
doaj   +1 more source

Down Regulation with Luteal GnRH Agonist Therapy in Euploid Embryo Transfers Does Not Impact Pregnancy Rates [PDF]

, 2020
Introduction : Gonadotropin-releasing hormone (GnRH) agonists have been used during assisted reproductive technology (ART) treatment for pituitary suppression and stimulation.
Bergin, MD, Keri, Copperman, MD, Alan, Gounko, Dmitry, Lee, Joseph, Levin, Isabelle   +4 more
core   +1 more source