Results 31 to 40 of about 419,324 (239)

6-Bromohypaphorine from Marine Nudibranch Mollusk Hermissenda crassicornis is an Agonist of Human α7 Nicotinic Acetylcholine Receptor

Marine Drugs, 2015
6-Bromohypaphorine (6-BHP) has been isolated from the marine sponges Pachymatisma johnstoni, Aplysina sp., and the tunicate Aplidium conicum, but data on its biological activity were not available.
Igor E. Kasheverov, Irina V. Shelukhina, Denis S. Kudryavtsev, Tatyana N. Makarieva, Ekaterina N. Spirova, Alla G. Guzii, Valentin A. Stonik, Victor I. Tsetlin   +7 more
doaj   +1 more source

A simple open source bioinformatic methodology for initial exploration of GPCR ligands’ agonistic/antagonistic properties

Pharmacology Research & Perspectives, 2020
Drug development is an arduous procedure, necessitating testing the interaction of a large number of potential candidates with potential interacting (macro)molecules.
Athanasios A. Panagiotopoulos, Christina Papachristofi, Konstantina Kalyvianaki, Panagiotis Malamos, Panayiotis A. Theodoropoulos, George Notas, Theodora Calogeropoulou, Elias Castanas, Marilena Kampa   +8 more
doaj   +1 more source

Impact of dextroamphetamine substitution on the use of illicit amphetamines in adults with amphetamine dependence: a study protocol for the multicentre double blind randomised controlled trial ATLAS4Dependence

BMJ Open
Introduction There is limited evidence on how to effectively treat individuals from marginalised populations with dependence on amphetamine and/or methamphetamine (collectively referred to hereafter as amphetamine dependence).
, Jörg Assmus, Kjell Arne Johansson, Nicholas Lintzeris, Fatemeh Chalabianloo, Anne Halmøy, Lars T Fadnes, Nadine Ezard, Brendan Clifford, John Fredrik Askjer, Olav Spigset, Torgeir Gilje Lid, Jon Mordal, Else-Marie Løberg, Christina Dahl Andersen, Jan Tore Daltveit, Aleksander H Erga, Kristin K Solli, Minna A K Hansen, Christian Ohldieck, Christer F Aas, Trond Aamo, Tine B Edvardsdal, Siv-Elin L Carlsen, Prayash Chaudhary, Marianne Cook Pierron, Gry I Dale, Silvana De Pirro, Karl Trygve Druckrey-Fiskaan, Zhanna Gaulen, Beate H Trettenes, Minna AK Hansen, Mette H Nordbotn, Line Holtan, Arild Knutsen, Kristin K Solli, Heidi F Kristiansen, Svanhild Mellingen, Maria K Olsvold, Solveig IS Reinertsen, Kristin Sannerud, Krista Siefried, Bente Sikveland, Morten Sommerbakk, Herman Steffensen, Jørn H Vold   +45 more
doaj   +1 more source

Functional GLP-1R antibodies identified from a synthetic GPCR-focused library demonstrate potent blood glucose control

mAbs, 2021
G protein-coupled receptors (GPCRs) are a group of seven-transmembrane receptor proteins that have proven to be successful drug targets. Antibodies are becoming an increasingly promising modality to target these receptors due to their unique properties ...
Qiang Liu, Pankaj Garg, Burcu Hasdemir, Linya Wang, Emily Tuscano, Emily Sever, Erica Keane, Ana G Lujan Hernandez, Tom Z. Yuan, Eric Kwan, Joyce Lai, Greg Szot, Sreenivasan Paruthiyil, Fumiko Axelrod, Aaron K. Sato   +14 more
doaj   +1 more source

Namodenoson at the Crossroad of Metabolic Dysfunction-Associated Steatohepatitis and Hepatocellular Carcinoma

Biomedicines
Namodenoson (CF102) is a small, orally available, anti-inflammatory, and anti-cancer drug candidate currently in phase 2B trial for the treatment of metabolic dysfunction-associated steatohepatitis (MASH; formerly known as non-alcoholic steatohepatitis ...
Ohad Etzion, Avital Bareket-Samish, David Yardeni, Pnina Fishman   +3 more
doaj   +1 more source

Improvement of irritable bowel syndrome with glucagon like peptide-1 receptor agonists: a systematic review and meta-analysis

Frontiers in Endocrinology
IntroductionIrritable bowel syndrome (IBS) is a severe gastrointestinal condition with symptoms like pain, bloating, diarrhea, and constipation. Glucagon-like peptide-1 (GLP-1) receptors, expressed in the central nervous system and peripheral tissues ...
Mohamed E. A. Mostafa, Tariq Alrasheed
doaj   +1 more source

Potential Adiponectin Receptor Response Modifier Therapeutics

Frontiers in Endocrinology, 2019
Many human diseases may benefit from adiponectin replacement therapy, but due to pharmacological disadvantages of the intact protein, druggable options focus on peptidic, and small molecule agonists of the adiponectin receptor.
Laszlo Otvos, Laszlo Otvos, Laszlo Otvos
doaj   +1 more source

The effect of fruit smoothie supplementation on psychological distress and biomarkers among people with opioid dependence receiving opioid agonist therapy: a randomized controlled trial

BMC Medicine
Background Unhealthy diets are common among individuals with opioid dependence. While fruit- and vegetable-rich diets have shown mental health benefits, evidence is limited for those receiving opioid agonist therapy (OAT).
Elaheh Javadi Arjmand, Lise Margrete Thomassen, Karl Trygve Druckrey-Fiskaaen, Einar Furulund, Jørn Henrik Vold, Tesfaye Madebo, Rune Blomhoff, Jan Tore Daltveit, Hege Berg Henriksen, Fatemeh Chalabianloo, Kjell Arne Johansen, Torgeir Gilje Lid, Lars Thore Fadnes, the ATLAS4LAR study group   +13 more
doaj   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source