Results 61 to 70 of about 467,003 (192)

The case for absolute ligand discrimination : modeling information processing and decision by immune T cells [PDF]

, 2015
Some cells have to take decision based on the quality of surroundings ligands, almost irrespective of their quantity, a problem we name "absolute discrimination". An example of absolute discrimination is recognition of not-self by immune T Cells. We show
Altan-Bonnet, Grégoire, François, Paul
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Rates and Equilibria for a Photoisomerizable Antagonist at the Acetylcholine Receptor of Electrophorus Electroplaques [PDF]

, 1985
Voltage-jump and light-flash experiments have been performed on isolated Electrophorus electroplaques exposed simultaneously to nicotinic agonists and to the photoisomerizable compound 2,2'-bis-[α-(trimethylammonium)methyl]-azobenzene (2BQ).
Erlanger, Bernard F., Krouse, Mauri E., Lester, Henry A., Wassermann, Norbert H.   +3 more
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Anticholinergic therapy for acute asthma in children. [PDF]

, 2012
Inhaled anticholinergics as single agent bronchodilators (or in combination with beta(2)-agonists) are one of the several medications available for the treatment of acute asthma in ...
Beakes, Beck, Benito Fernandez, Bever, Bratteby, British Thoracic Society, Brown, Browne, Calvo, Cook, Craven, Cugell, DeStefano, Ducharme, Everard, Goggin, Gross, Guill, Hayday, Iramain, Lew, Lin, Lung, Mallol, McDonald, Mirsadraee, National Asthma Council Australia, Ni, Plotnick, Pulejo, Quereshi, Qureshi, Rayner, Reisman, Rodrigo, Schuh, Sienra Monge, Storms, Storr, Tal, Timsit, Ulrik, Undem, Wade, Ward, Ward, Yeung, Youngchaiyud, Zimmerman, Zorc   +49 more
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The different effects of four adenosine receptors in liver fibrosis

Frontiers in Pharmacology
BackgroundThe adenosine–adenosine receptor pathway plays important roles in the immune system and inflammation. Four adenosine receptors (i.e., A1R, A2AR, A2BR, and A3R) have been identified.
Lan Yang, Zhao-wei Gao, Xi Wang, Xia-nan Wu, Si-min Li, Ke Dong, Xiao-ming Zhu   +6 more
doaj   +1 more source

Target sites for chemical regulation of strigolactone signaling

Frontiers in Plant Science, 2014
Demands for plant growth regulators (chemicals that control plant growth) are increasing globally, especially in developing countries. Both positive and negative plant growth regulators are widely used to enhance crop production and to suppress unwanted ...
Hidemitsu eNakamura, Tadao eAsami, Tadao eAsami, Tadao eAsami   +3 more
doaj   +1 more source

Ligand-Specific Regulation of the Endogenous Mu-Opioid Receptor by Chronic Treatment with Mu-Opioid Peptide Agonist [PDF]

, 2013
Since the discovery of the endomorphins (EM), the postulated endogenous peptide agonists of the mu-opioid receptors, several analogues have been synthesized to improve their binding and pharmacological profiles.
Birkás, Erika, Bozó, Beáta, Cinar, Resat, Dochnal, Roberta Beatrix, Fábián, Gabriella, Kicsi, Emese Gabriella, Kékesi, Orsolya, Murányi, Marianna, Mácsai, Mónika, Szabó, Gyula, Szűcs, Mária, Tóth, Géza, Zentai, András   +12 more
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The synthesis of cis- and trans-3-(4-hydroxyphenyl)cyclobutanecarboxylic acids and the study of their derivatives as GPR-40 receptor ligands

Журнал органічної та фармацевтичної хімії, 2020
Aim. To synthesize cis- and trans-isomers of 3-(4-hydroxyphenyl)cyclobutanecarboxylic acid and evaluate the biological activity of their derivatives against GPR-40. Results and discussion.
I. O. Feskov, I. S. Kondratov, Yu. O. Kuchkovska, V. S. Naumchyk, O. V. Onopchenko, O. O. Grygorenko   +5 more
doaj   +1 more source

Improvement of irritable bowel syndrome with glucagon like peptide-1 receptor agonists: a systematic review and meta-analysis

Frontiers in Endocrinology
IntroductionIrritable bowel syndrome (IBS) is a severe gastrointestinal condition with symptoms like pain, bloating, diarrhea, and constipation. Glucagon-like peptide-1 (GLP-1) receptors, expressed in the central nervous system and peripheral tissues ...
Mohamed E. A. Mostafa, Tariq Alrasheed
doaj   +1 more source

Antagonist conditioning contractions impair agonist functioning [PDF]

, 2010
This study assessed the effect of antagonist conditioning contractions (ACC) on the subsequent force and electromyography of an agonist. Twelve subjects performed isokinetic elbow flexion on a dynamometer in 4 test conditions including a baseline ...
Ebben, William, Fauth, McKenzie, Garceau, Luke, Gray, Aaron, Hanson, Phillip, Hsu, Brittni, Lutsch, Brittney, Szalkowski, Chris, Yoon, Tejin   +8 more
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Histamine stimulates the proliferation of small and large cholangiocytes by activation of both IP3/Ca2+ and cAMP-dependent signaling mechanisms [PDF]

, 2012
Although large cholangiocytes exert their functions by activation of cyclic adenosine 3',5'-monophosphate (cAMP), Ca(2+)-dependent signaling regulates the function of small cholangiocytes. Histamine interacts with four receptors, H1-H4HRs.
Fanyin Meng, FRANCHITTO, Antonio, GAUDIO, EUGENIO, Gianfranco D. Alpini, Guido Carpino, Hannah E. Shine, Heather L. Francis, Julie K. Venter, Kimberly K. Baker, MANCINELLI, ROMINA, Mellanie A. White, ONORI, PAOLO, RENZI, ANASTASIA, Sharon Demorrow, Taylor C. Francis, Yoshiyuki Ueno   +15 more
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