Results 61 to 70 of about 1,200,697 (382)

Oestrogenic and androgenic activity of oxybenzone and methylparaben in vitro

Arhiv za Higijenu Rada i Toksikologiju
Motivated by emerging concerns about health hazards associated with various industrial chemicals, this study investigated the disruption of endocrine system using well established in vitro assays.
Peranić Nikolina, Božičević Lucija, Vrček Ivana Vinković   +2 more
doaj   +1 more source

Agonists and Inhibitors of the cGAS-STING Pathway

Molecules
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is pivotal in immunotherapy. Several agonists and inhibitors of the cGAS-STING pathway have been developed and evaluated for the treatment of various diseases. The agonists
Xiaoxuan Yu, Linxiang Cai, Jingyue Yao, Cenming Li, Xiaoyong Wang   +4 more
doaj   +1 more source

Nikotinski acetilholinski receptor kot farmakološka tarča pri pljučnem raku

Acta Biologica Slovenica, 2022
Rak pljuč je zelo razširjena oblika raka z nizko stopnjo preživetja. Kajenje tobaka predstavlja glavni dejavnik tveganja za razvoj raka pljuč, saj v tobačnem dimu najdemo veliko rakotvornih snovi.
Veno Kononenko, Tadeja Bele, Sara Novak, Igor Križaj, Damjana Drobne, Tom Turk   +5 more
doaj   +1 more source

Allosteric coupling from G protein to the agonist binding pocket in GPCRs

Nature, 2016
G-protein-coupled receptors (GPCRs) remain the primary conduit by which cells detect environmental stimuli and communicate with each other. Upon activation by extracellular agonists, these seven-transmembrane-domain-containing receptors interact with ...
Brian T DeVree, Jacob P. Mahoney, Gisselle A. Vélez-Ruiz, S. Rasmussen, A. Kuszak, E. Edwald, J. Fung, A. Manglik, M. Masureel, Yang Du, R. Matt, E. Pardon, J. Steyaert, B. Kobilka, R. Sunahara   +14 more
semanticscholar   +1 more source

Rates and equilibria at the acetylcholine receptor of electrophorus electroplaques. A study of neurally evoked postsynaptic currents and of voltage-jump relaxations [PDF]

, 1977
Kinetic measurements are employed to reconstruct the steady-state activation of acetylcholine [Ach] receptor channels in electrophorus electroplaques. Neurally evoked postsynaptic currents (PSCs) decay exponentially; at 15°C the rate constant, α, equals ...
Lester, Henry A., Sheridan, Robert E.
core   +2 more sources

Molecular signatures of a TLR4 agonist-adjuvanted HIV-1 vaccine candidate in humans [PDF]

, 2018
Systems biology approaches have recently provided new insights into the mechanisms of action of human vaccines and adjuvants. Here, we investigated early transcriptional signatures induced in whole blood of healthy subjects following vaccination with a ...
Anderson, J, Harandi, AM, Kratochvil, S, McKay, PF, Olafsdottir, TA, Persson, J, Shattock, RJ, östensson, M   +7 more
core   +2 more sources

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates

Science Translational Medicine, 2018
The small-molecule AT-121 is an agonist of nociceptin and mu opioid peptide receptors and mediates analgesia without opioid-associated side effects in nonhuman primates.
H. Ding, N. Kiguchi, D. Yasuda, Pankaj R. Daga, W. Polgar, James J Lu, P. Czoty, S. Kishioka, N. Zaveri, M. Ko   +9 more
semanticscholar   +1 more source

Quinolones modulate ghrelin receptor signaling: potential for a novel small molecule scaffold in the treatment of cachexia [PDF]

, 2018
Cachexia is a metabolic wasting disorder characterized by progressive weight loss, muscle atrophy, fatigue, weakness, and appetite loss. Cachexia is associated with almost all major chronic illnesses including cancer, heart failure, obstructive ...
Cano, Rafael, Juan Rodríguez, Rocío, Kandil, Dalia, McGlacken, Gerard P., Pastor Cavada, Elena, Schellekens, Harriët, Shaban, Hamdy, Shanahan, Rachel, Torres-Fuentes, Cristina   +8 more
core   +3 more sources

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

FEBS Open Bio, EarlyView.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová, Tímea Kurdiová, Daria Barkova, Natália Pálešová, Jana Babulicová, Silvia Tyčiaková, Marta Novotová, Mária Balážová, Miroslav Sabo, Václav Pustka, Jozef Ukropec, Barbara Ukropcová   +11 more
wiley   +1 more source