Results 71 to 80 of about 799,914 (365)

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Design Paradigms Based on Spring Agonists for Underactuated Robot Hands: Concepts and Application [PDF]

arXiv, 2020
In this paper, we focus on a rarely used paradigm in the design of underactuated robot hands: the use of springs as agonists and tendons as antagonists. We formalize this approach in a design matrix also considering its interplay with the underactuation method used (one tendon for multiple joints vs. multiple tendons on one motor shaft).
arxiv  

Towards an Understanding of the Mode of Action of Human Aromatase Activity for Azoles through Quantum Chemical Descriptors-Based Regression and Structure Activity Relationship Modeling Analysis

Molecules, 2020
Aromatase is an enzyme member of the cytochrome P450 superfamily coded by the CYP19A1 gene. Its main action is the conversion of androgens into estrogens, transforming androstenedione into estrone and testosterone into estradiol.
Chayawan Chayawan, Cosimo Toma, Emilio Benfenati, Ana Y. Caballero Alfonso   +3 more
doaj   +1 more source

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

ChemR23 activation reprograms macrophages toward a less inflammatory phenotype and dampens carcinoma progression

Frontiers in Immunology, 2023
IntroductionTumor Associated Macrophages (TAM) are a major component of the tumor environment and their accumulation often correlates with poor prognosis by contributing to local inflammation, inhibition of anti-tumor immune response and resistance to ...
Margot Lavy, Vanessa Gauttier, Alison Dumont, Florian Chocteau, Sophie Deshayes, Judith Fresquet, Virginie Dehame, Virginie Dehame, Isabelle Girault, Charlène Trilleaud, Stéphanie Neyton, Caroline Mary, Philippe Juin, Philippe Juin, Nicolas Poirier, Sophie Barillé-Nion, Christophe Blanquart   +16 more
doaj   +1 more source

Combination inhaled steroid and long-acting beta-agonist in addition to tiotropium versus tiotropium or combination alone for chronic obstructive pulmonary disease (Review) [PDF]

, 2011
Background The long-acting bronchodilator tiotropium and single inhaler combination therapy of inhaled corticosteroids and long-acting beta(2)-agonists are both commonly used for maintenance treatment of chronic obstructive pulmonary disease.
Appleton, Barr, Beeh, Effing, Fang, Lacasse, Nannini, Nannini, Nannini, Welsh, Yang   +10 more
core   +1 more source

Matrigel inhibits elongation and drives endoderm differentiation in aggregates of mouse embryonic stem cells

FEBS Open Bio, EarlyView.
Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel, Rachel Brown, Alexa Rabeling, Mubeen Goolam   +3 more
wiley   +1 more source

Intuitive control of myoelectric prostheses with agonist-antagonist interface and magnetomicrometery: narrative review [PDF]

arXiv, 2023
Proprioception is crucial in intuitive control of prosthetic limbs and therefor contributes to intuitive prosthetic use. The agonist-antagonist myoneural interface (AMI) is an prosthetic innovation with enhanced control, reduced pain, and heightened proprioceptive sensation in clinical experiments.
arxiv  

Inherent rhythm of smooth muscle cells in rat mesenteric arterioles: an eigensystem formulation [PDF]

Phys. Rev. E 93, 042415 (2016), 2016
On the basis of experimental data and mathematical equations in the literature, we remodel the ionic dynamics of smooth muscle cells (SMCs) as an eigensystem formulation, which is valid for investigating finite variations of variables from the equilibrium like in common experimental operations.
arxiv   +1 more source

RIG-I agonist SLR10 promotes macrophage M1 polarization during influenza virus infection

Frontiers in Immunology, 2023
RationaleA family of short synthetic, triphosphorylated stem-loop RNAs (SLRs) have been designed to activate the retinoic-acid-inducible gene I (RIG-I) pathway and induce a potent interferon (IFN) response, which may have therapeutic potential.
Wenxin Wu, Wei Zhang, Jeremy S. Alexandar, J. Leland Booth, Craig A. Miller, Chao Xu, Jordan P. Metcalf, Jordan P. Metcalf, Jordan P. Metcalf   +8 more
doaj   +1 more source