Results 1 to 10 of about 261,867 (135)
Frontiers in Bioengineering and Biotechnology, 2022 Toll-like receptors (TLRs) are important pattern recognition receptor(s) known to mediate the sensing of invading pathogens and subsequent immune responses.
Chenli Qiu +16 more
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TRPV3: Structure, Diseases and Modulators
Molecules, 2023 Transient receptor potential vanillin 3 (TRPV3) is a member of the transient receptor potential (TRP) superfamily. As a Ca2+-permeable nonselective cation channel, TRPV3 can recognize thermal stimulation (31–39 °C), and it plays an important regulatory ...
Wuyue Su +5 more
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Molecules, 2021 Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint inflammation, cartilage damage and bone destruction. Although the pharmacological treatment of RA has evolved over the last few years, the new drugs have serious side ...
Letizia Crocetti +10 more
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Pharmaceuticals, 2021 Activation of the CB2 receptor has been shown to have anti-inflammatory and antinociceptive effects without causing psychoactive effects. Previously, we reported that the compound ethyl 2(2-(N-(2,3-dimethylphenyl) phenylsulfonamido)acetamido)benzoate ...
Yaliang Tang +4 more
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eLife, 2022 To clarify the determinants of agonist efficacy in pentameric ligand-gated ion channels, we examined a new compound, aminomethanesulfonic acid (AMS), a molecule intermediate in structure between glycine and taurine.
Josip Ivica +4 more
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Focusing on Adenosine Receptors as a Potential Targeted Therapy in Human Diseases
Cells, 2020 Adenosine is involved in a range of physiological and pathological effects through membrane-bound receptors linked to G proteins. There are four subtypes of adenosine receptors, described as A1AR, A2AAR, A2BAR, and A3AR, which are the center of cAMP ...
Wiwin Is Effendi +3 more
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Identifying Ligand Binding Conformations of the β2-Adrenergic Receptor by Using Its Agonists as Computational Probes [PDF]
, 2011 Recently available G-protein coupled receptor (GPCR) structures and biophysical studies suggest that the difference between the effects of various agonists and antagonists cannot be explained by single structures alone, but rather that the conformational
Ashley M. Buckle +64 more
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Doubles-agonistes, tri-agonistes et multi-agonistes incrétines/glucagon
Médecine des Maladies Métaboliques, 2021 Resume L’innovation pharmacologique en diabetologie est un veritable defi. La nouvelle famille des co-agonistes des recepteurs GIP/GLP-1 represente une avancee therapeutique importante pour ameliorer la prise en charge du diabete de type 2 (DT2). L’activation des deux recepteurs incretines peut avoir des effets metaboliques additifs en comparaison a ...
Phan, Franck, Andreelli, Fabrizio
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Mechanism of Peptide Agonist Binding in CXCR4 Chemokine Receptor
Frontiers in Molecular Biosciences, 2022 Chemokine receptors are key G-protein-coupled receptors (GPCRs) that control cell migration in immune system responses, development of cardiovascular and central nervous systems, and numerous diseases. In particular, the CXCR4 chemokine receptor promotes
Shristi Pawnikar, Yinglong Miao
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International Journal of Translational Medicine, 2021 Angiogenesis is essential during development or when tissue restoration and oxygenation is required. Limited or excessive formation of blood vessels is a hallmark of several pathologies, and many angiogenesis-related pathways are being studied to ...
Athanasios Xanthopoulos +3 more
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