A meta-analysis and systematic review of randomized controlled trials with degarelix versus gonadotropin-releasing hormone agonists for advanced prostate cancer [PDF]
, 2016 Our aim was to systematically evaluate the benefits of degarelix as antagonist versus agonists of gonadotropin-releasing hormones (GnRH) for the treatment of advanced prostate cancer (PC).
CATTARINO, SUSANNA +10 more
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Frontiers in Immunology, 2023 Toll-like receptors (TLRs) serve as the body’s first line of defense, recognizing both pathogen-expressed molecules and host-derived molecules released from damaged or dying cells. The wide distribution of different cell types, ranging from epithelial to
Suprabhat Mukherjee +5 more
doaj +1 more source
Addition to inhaled corticosteroids of long-acting beta2-agonists versus anti-leukotrienes for chronic asthma [PDF]
, 2011 Asthma patients who continue to experience symptoms despite being on regular inhaled corticosteroids (ICS) represent a management challenge. Long-acting beta2-agonists (LABA) or anti-leukotrienes (LTRA) are two treatment options that could be considered ...
Adams +207 more
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Small Molecule Follicle-Stimulating Hormone Receptor Agonists and Antagonists
Frontiers in Endocrinology, 2019 The follicle-stimulating hormone receptor (FSHR) has been targeted therapeutically for decades, due to its pivotal role in reproduction. To date, only purified and recombinant/biosimilar FSH have been used to target FSHR in assisted reproduction, with ...
Ross C. Anderson +3 more
doaj +1 more source
Anticholinergic therapy for acute asthma in children. [PDF]
, 2012 Inhaled anticholinergics as single agent bronchodilators (or in combination with beta(2)-agonists) are one of the several medications available for the treatment of acute asthma in ...
Beakes +49 more
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Anti-tumor Activity of Toll-Like Receptor 7 Agonists
Frontiers in Pharmacology, 2017 Toll-like receptors (TLRs) are a class of pattern recognition receptors that play a bridging role in innate immunity and adaptive immunity. The activated TLRs not only induce inflammatory responses, but also elicit the development of antigen specific ...
Huju Chi +6 more
doaj +1 more source
Formoterol versus short-acting beta-agonists as relief medication for adults and children with asthma [PDF]
, 2010 Background Formoterol is a long-acting beta(2)-agonist but because it has a fast onset of action it can also be used as a relief medication. Objectives To asses the efficacy and safety of formoterol as reliever therapy in comparison to short-acting ...
Cates, CJ, Welsh, EJ
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Cholinergic modulation of dopamine overflow in the rat neostriatum: A fast cyclic voltammetric study in vitro [PDF]
, 1994 Stimulus-evoked dopamine overflow in rat neostriatal slices was determined using fast cyclic voltammetry. The dopamine efflux induced by intrastriatal stimulation increased with stimulus intensity and was found to be enhanced by more than 100% upon ...
Kudernatsch, Martina, Sutor, Bernd
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Atherosclerosis induced by endogenous and exogenous toll-like receptor (TLR)1 or TLR6 agonists
Journal of Lipid Research, 2012 Atherosclerosis is a chronic inflammatory vascular disease. Toll-like receptors (TLRs) are major initiators of inflammation. TLR2 promotes atherosclerosis in LDL receptor (LDLr)-deficient mice fed a high-fat diet (HFD).
Linda K. Curtiss +3 more
doaj +1 more source
Approaches for the modulation of mechanosensitive MscL channel pores
Frontiers in Chemistry, 2023 MscL was the first mechanosensitive ion channel identified in bacteria. The channel opens its large pore when the turgor pressure of the cytoplasm increases close to the lytic limit of the cellular membrane. Despite their ubiquity across organisms, their
Benjamin J. Lane +3 more
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