Results 41 to 50 of about 261,867 (135)
Ciência Rural, 2011 Uma meta-análise foi realizada para avaliar a associação da ractopamina com variáveis nutricionais e de desempenho em suínos. A base de dados contemplou 29 artigos publicados em periódicos nacionais e internacionais entre 1990 e 2007, totalizando 155 ...
Ines Andretta +5 more
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Peptide Phage Display as a Tool for Drug Discovery: Targeting Membrane Receptors
Molecules, 2011 Ligands selected from phage-displayed random peptide libraries tend to be directed to biologically relevant sites on the surface of the target protein. Consequently, peptides derived from library screenings often modulate the target protein’s activity in
Tomaz Bratkovic +2 more
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Ligand-Specific Regulation of the Endogenous Mu-Opioid Receptor by Chronic Treatment with Mu-Opioid Peptide Agonist [PDF]
, 2013 Since the discovery of the endomorphins (EM), the postulated endogenous peptide agonists of the mu-opioid receptors, several analogues have been synthesized to improve their binding and pharmacological profiles.
Birkás, Erika +12 more
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Design and synthesis of ERα agonists: Effectively reduce lipid accumulation
Frontiers in Chemistry, 2022 In recent years, the incidence of non-alcoholic fatty liver disease (NAFLD) has been increasing worldwide. Hepatic lipid deposition is a major feature of NAFLD, and insulin resistance is one of the most important causes of lipid deposition.
Jinfei Yang +4 more
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G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease [PDF]
, 2015 G protein-coupled receptor 35 (GPR35) is an orphan receptor, discovered in 1998, that has garnered interest as a potential therapeutic target through its association with a range of diseases.
Amanda E Mackenzie +4 more
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Cyclic nucleotide-gated channels: structural basis of ligand efficacy and allosteric modulation [PDF]
, 1997 Most working proteins, including metabolic enzymes, transcription regulators, and membrane receptors, transporters, and ion channels, share the property of allosteric coupling. The term 'allosteric' means that these proteins mediate indirect interactions
Lester, Henry A. +2 more
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Advanced Science, 2020 The phytohormone abscisic acid (ABA) is the best‐known stress signaling molecule in plants. ABA protects sessile land plants from biotic and abiotic stresses.
Kamalani Achala H. Hewage +5 more
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T-Cell activation: a queuing theory analysis at low agonist density [PDF]
, 2006 We analyze a simple linear triggering model of the T-cell receptor (TCR) within the framework of queuing theory, in which TCRs enter the queue upon full activation and exit by downregulation.
Wedagedera, J. R., Burroughs, Nigel John
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PPARγ Modulators in Lung Cancer: Molecular Mechanisms, Clinical Prospects, and Challenges
BiomoleculesLung cancer is one of the most lethal malignancies worldwide. Peroxisome proliferator-activated receptor gamma (PPARγ, NR1C3) is a ligand-activated transcriptional factor that governs the expression of genes involved in glucolipid metabolism, energy ...
Jiyun Zhang, Miru Tang, Jinsai Shang
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From Rate-Limiting Enzyme to Therapeutic Target: The Promise of NAMPT in Neurodegenerative Diseases
Frontiers in Pharmacology, 2022 Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in the nicotinamide adenine dinucleotide (NAD) salvage pathway in mammals. It is of great significance in the metabolic homeostasis and cell survival via synthesizing nicotinamide
Yumeng Zhu +8 more
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