Results 181 to 190 of about 35,097 (228)
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Placenta, 2002
Placentae of three hystricimorph rodents--capybara, agouti and paca--were examined by conventional histology, immunohistochemistry for cytokeratin and vimentin, and TUNEL staining. The placentae were divided into lobules of labyrinthine syncytium separated by interlobular and marginal trophoblast.
Miglino, M. +3 more
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Placentae of three hystricimorph rodents--capybara, agouti and paca--were examined by conventional histology, immunohistochemistry for cytokeratin and vimentin, and TUNEL staining. The placentae were divided into lobules of labyrinthine syncytium separated by interlobular and marginal trophoblast.
Miglino, M. +3 more
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Molecular Interaction of Agouti Protein and Agouti-Related Protein with Human Melanocortin Receptors
Biochemistry, 1998Agouti protein and the Agouti-related protein (AGRP) are antagonists of the melanocortin-3 receptor and melanocortin-4 receptor. Both proteins contain 10 cysteines in the C-terminal domain arranged in five disulfide bonds. One possible arrangement of the disulfide bonds predicts an octapeptide loop, and the chemical properties of four residues within ...
M R, Tota +6 more
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Agouti‐Related Proteins (AGRPs) and Agouti‐Signaling Peptide (ASIP) in Fish and Chicken
Annals of the New York Academy of Sciences, 2005Abstract: We performed an intensive search on sequence databases to identify orthologues of ASIP and AGRP peptides in a number of different species, revealing a number of genomic fragments coding for the C‐terminal part of agouti‐related motifs, different from annotated peptide sequences, including one fragment from chicken, two from zebrafish, two ...
Janis, Klovins, Helgi B, Schiöth
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Peptoid mimics of agouti related protein
Bioorganic & Medicinal Chemistry Letters, 2003The Agouti Related Protein (AGRP) is an endogenous antagonist of melanocortin-3 and -4 receptors, each of which plays a key role in body weight homeostasis. We designed a peptoid trimer based on AGRP 111-113 in which a single chiral atom is used to partially restrain the backbone structure. Peptoid 5 displaced both radiolabeled Nle4-alpha-MSH (IC(50)=3.
Darren A, Thompson +6 more
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Structures of the Agouti Signaling Protein
Journal of Molecular Biology, 2005Expression of the agouti signaling protein (ASIP) during hair growth produces the red/yellow pigment pheomelanin. ASIP, and its neuropeptide homolog the agouti-related protein (AgRP) involved in energy balance, are novel, paracrine signaling molecules that act as inverse agonists at distinct subsets of melanocortin receptors. Ubiquitous ASIP expression
Joseph C, McNulty +7 more
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Bioactive Motifs of Agouti Signal Protein
Experimental Cell Research, 2000The switch between the synthesis of eu- and pheomelanins is modulated by the interaction of two paracrine signaling molecules, alpha-melanocyte stimulating hormone (MSH) and agouti signal protein (ASP), which interact with melanocytes via the MSH receptor (MC1R).
V M, Virador +4 more
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Body and organ mass in agouti and non-agouti deer mice (Peromyscus maniculatus)
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2001Body, adrenal, brain, heart, liver, kidney, spleen and testis masses were determined for agouti and non-agouti deer mice (Peromyscus maniculatus gracilis) of both sexes. Body mass was highest for non-agouti females and lowest for agouti females; and sex differences in body mass were significant for agouti, but not non-agouti, deer mice.
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Modification of the dominance of agouti to non-agouti in the mouse
Journal of Genetics, 1934The foregoing series of experiments, demonstrating the way in which the phenotypedark arises by inheritance, has shown that this type depends upon the presence of at least two genes: (1) the well-known recessive non-agouti, a, in the heterozygous condition; and (2) one or more dominant or semi-dominant modifying factors, U1 [U2…], whose effect is to ...
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