Results 1 to 10 of about 23,001 (200)

Charge Characteristics of Agouti-Related Protein Implicate Potent Involvement of Heparan Sulfate Proteoglycans in Metabolic Function [PDF]

iScience, 2019
Summary: The endogenous melanocortin peptide agouti-related protein (AgRP) plays a well-known role in foraging, but its contribution to metabolic regulation is less understood.
Jihuan Chen, Valerie Chen, Tomoya Kawamura, Ivy Hoang, Yang Yang, Ashley Tess Wong, Ryan McBride, Vez Repunte-Canonigo, Glenn L. Millhauser, Pietro Paolo Sanna   +9 more
doaj   +5 more sources

Agouti-related protein as the glucose signaling sensor in the central melanocortin circuits in regulating fish food intake [PDF]

Frontiers in Endocrinology, 2022
Agouti-related protein (AgRP) is a neuropeptide synthesized by AgRP/NPY neurons and transcribed as 132 amino acids in humans and 142 amino acids (AgRP1) in Japanese seabass (Lateolabrax maculatus) fish.
Juan Han, Xiaofang Liang, Yanzhi Guo, Xiaoliang Wu, Ziqi Li, Tiannuo Hong   +5 more
doaj   +2 more sources

Differential effects of overexpression of mutant huntingtin and TDP-43 in agouti-related protein neurons in the arcuate nucleus of the hypothalamus in mice [PDF]

Acta Neuropathologica Communications
The spectrum of frontotemporal dementia/amyotrophic lateral sclerosis (FTD/ALS) and Huntington disease (HD) are fatal neurodegenerative disorders with no major disease-modifying therapies. Recent work has shown that the hallmark pathological proteins TAR
Jennifer Oraha, Ronja Wagner, Sofia Bergh, Nicola J Lee, Deniz Kirik, Åsa Petersén   +5 more
doaj   +2 more sources

Targeted proteomics analysis in type 1 diabetes identifies lower agouti-related protein levels in individuals with impaired hypoglycaemia awareness [PDF]

Scientific Reports
Impaired awareness of hypoglycaemia (IAH) is a complication of diabetes treatment, whereby individuals are no longer able to feel an oncoming hypoglycaemic event.
Rita D. M. Varkevisser, Agnese Petrera, Stefanie M. Hauck, Dick Mul, Henk-Jan Aanstoot, Andrew Paterson, Bruce H. R. Wolffenbuttel, Melanie M. van der Klauw, Dutch Type 1 Diabetes Biomarker Group   +8 more
doaj   +2 more sources

Association of Inflammatory and Cardiovascular Proteomics Biomarkers With Indices of Heart Rate Variability in the General Population: KORA S4/FF4 Study [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background We sought to investigate the association between circulating inflammatory and cardiovascular proteomics biomarkers and cardiac autonomic nervous dysfunction–sensitive heart rate variability indices.
Kolade Oluwagbemigun, Dan Ziegler, Alexander Strom, Margit Heier, Gidon Bönhof, Michael Roden, Wolfgang Rathmann, Christa Meisinger, Annette Peters, Stefanie M. Hauck, Agnese Petrera, Moritz F. Sinner, Stefan Kääb, Barbara Thorand, Christian Herder   +14 more
doaj   +2 more sources

Glucose Intake during the Neonatal Period Modulates the Central Melanocortin System with Breed-Specific Differences [PDF]

The Journal of Poultry Science
Glucose is the primary substrate for cellular energy production, and its blood concentration is tightly regulated. This study investigated the effect of glucose supplementation during the first three days post-hatching on growth performance and ...
Kazuki Kimura, Yuuna Watanabe, Sachi Ashizawa, Koichi Matsushita, Nobuhiro Nakao, Yoshiyuki Ohta, Jun-ichi Shiraishi   +6 more
doaj   +2 more sources

mTORC1 Signaling in AgRP Neurons Is Not Required to Induce Major Neuroendocrine Adaptations to Food Restriction

Cells, 2023
Hypothalamic mTORC1 signaling is involved in nutrient sensing. Neurons that express the agouti-related protein (AgRP) are activated by food restriction and integrate interoceptive and exteroceptive signals to control food intake, energy expenditure, and ...
Gabriel O. de Souza, Pryscila D. S. Teixeira, Niels O. S. Câmara, Jose Donato   +3 more
doaj   +1 more source

Malocclusion impairs cognitive behavior via AgRP signaling in adolescent mice

Frontiers in Neuroscience, 2023
IntroductionOcclusal disharmony induced by deteriorating oral health conditions, such as tooth loss and decreased masticatory muscle due to sarcopenia, is one of the causes of cognitive impairment.
Junya Kusumoto, Koji Ataka, Koji Ataka, Haruki Iwai, Yasuhiko Oga, Keita Yamagata, Kanako Marutani, Takanori Ishikawa, Akihiro Asakawa, Shouichi Miyawaki   +9 more
doaj   +1 more source

Integration of Nutrient Sensing in Fish Hypothalamus

Frontiers in Neuroscience, 2021
The knowledge regarding hypothalamic integration of metabolic and endocrine signaling resulting in regulation of food intake is scarce in fish. Available studies pointed to a network in which the activation of the nutrient-sensing (glucose, fatty acid ...
José L. Soengas
doaj   +1 more source

Does an acute bout of high intensity interval exercise suppress appetite in obese women?

Pedagogy of Physical Culture and Sports, 2020
Purpose: The aim of this study was to investigate the 24 hour response of appetite and energy intake and the amount of Agouti-Related Protein to the high intensity interval exercise in obese untrained women.
Sepideh Khalaj, Bahman Mirzaei
doaj   +1 more source