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A Role for the Agouti-Related Protein Promoter in Obesity and Type 2 Diabetes
Biochemical and Biophysical Research Communications, 2001The murine Agouti-Related Protein (mAGRP) is upregulated in obese and diabetic mice and can stimulate hyperphagia when overexpressed in transgenic models. Here we report upstream nucleotide sequences of the human hAGRP gene with putative recognition sites for transcription factors including a site for the STAT transactivators. A polymorphism (-38C-->T)
D K, Mayfield +5 more
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Agouti-related protein in patients with acute and weight-restored anorexia nervosa
Psychological Medicine, 2011BackgroundAn imbalance in appetite-regulating neuropeptides of the central nervous system has been associated with anorexia nervosa (AN), but the mechanisms of action are poorly understood. Agouti-related protein (AGRP), an orexigenic mediator of the hypothalamus, increases food intake and decreases energy expenditure in times of negative energy ...
J V, Merle +6 more
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Treadmill Exercise’s Reduction of Agouti-Related Protein Expression in Rat Liver
International Journal of Sport Nutrition and Exercise Metabolism, 2009Agouti-related protein (AGRP) is an orexigenic peptide secreted from the arcuate nucleus (ARC) of the hypothalamus. AGRP increases food intake and plays a role in energy balance, adiposity, weight gain, and growth-hormone release. The objective of the current study was to examine the effects of running exercise on resting hepatic, fundus, and pancreas ...
Abbass, Ghanbari-Niaki +6 more
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