Results 41 to 50 of about 339,684 (208)
BMC Medical Genetics, 2009 Background The agouti related protein (AGRP) is an endogenous antagonist of the melanocortin 4 receptor and is one of the most potent orexigenic factors.
Ignatovica Vita +5 more
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Novel Agouti-Related-Protein-Based Melanocortin-1 Receptor Antagonist
, 2016 The melanocortin receptors are G-protein coupled receptors (GPCRs) that activate the cAMP signal transduction pathway and are stimulated by the melanocortin agonist α-melanocyte stimulating hormone (α-MSH).
Jerry Ryan Holder (2401027) +5 more
core +1 more source
Neuroendocrine and Molecular Interactions in Eating Disorders [PDF]
Psikiyatride Güncel Yaklaşımlar, 2014 There are three basic pillars for the development of eating disorders: genetic predisposition, neuro-endocrine-molecular changes in the brain and metabolic response to it.
Selma Bozkurt Zincir
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Plasma Levels of Agouti-Related Protein Are Increased in Obese Men [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2001 To investigate the relationship between peripheral blood levels of agouti-related protein (AGRP) and various parameters of obesity, we measured the plasma level of AGRP in 15 obese and 15 nonobese men and evaluated its relationship with body mass index (BMI), body fat weight, and visceral, sc, and total fat areas measured by computed tomography ...
A, Katsuki +10 more
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Agouti signal protein regulation in human melanoma cells
, 2003 Production of the pigment eumelanin is controlled by alpha-melanocyte stimulating hormone (alpha-MSH) stimulation of melanocortin 1 receptor (Mc1r), whereas production of pheomelanin results from agouti antagonism of alpha-MSH signalling through Mc1r ...
Kelly, Greg +2 more
core +1 more source
Transcriptional Regulation of Agouti-Related Protein (Agrp) in Transgenic Mice [PDF]
Endocrinology, 2004 AbstractAgouti-related protein (Agrp) encodes a hypothalamic neuropeptide that promotes positive energy balance by stimulating food intake and reducing energy expenditure. Agrp expression in the brain is restricted to neurons within the arcuate nucleus of the hypothalamus, and expression levels are elevated as a consequence of food deprivation.
Christopher B, Kaelin +3 more
openaire +2 more sources
Food Safety and Health, EarlyView.Circadian rhythm disruption impairs metabolic regulation, appetite control, and vascular function, promoting obesity and cardiovascular diseases. Evidence highlights a bidirectional relationship where metabolic disorders further disturb circadian timing.
Ghizal Fatima +4 more
wiley +1 more source
Frontiers in Neuroscience, 2018 Genetic manipulation of teleost endocrine systems started with transgenic overexpression of pituitary growth hormone. Such strategies enhance growth and reduce fertility, but the fish still breed.
Vance L. Trudeau
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The role of agouti-related protein in regulating body weight
Molecular Medicine Today, 1999 Defects in signaling by leptin, a hormone produced primarily by adipose tissue that informs the brain of the body's energy reserves, result in obesity in mice and humans. However, the majority of obese humans do not have abnormalities in leptin or its receptor but instead exhibit leptin resistance that could result from defects in downstream mediators ...
B D, Wilson, M M, Ollmann, G S, Barsh
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Pediatric Investigation, EarlyView.Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil +2 more
wiley +1 more source