Results 31 to 40 of about 339,684 (208)
Contribution of Melanocortin Receptor Exoloops to Agouti-related Protein Binding [PDF]
Journal of Biological Chemistry, 1999 Agouti-related protein (AGRP) is an endogenous antagonist of melanocortin action that functions in the hypothalamic control of feeding behavior. Although previous studies have shown that AGRP binds three of the five known subtypes of melanocortin receptor, the receptor domains participating in binding and the molecular interactions involved are ...
Y K, Yang +5 more
openaire +2 more sources
Psychiatry and Clinical Psychopharmacology, 2019 OBJECTIVES: Bipolar disorder (BD) is a chronic psychiatric disorder with a high prevalence of obesity. There are a number of hypotheses regarding the association between obesity and BD.
Evrim Özkorumak Karagüzel +5 more
doaj +1 more source
Cannabinoid type 1 receptor-containing axons innervate NPY/AgRP neurons in the mouse arcuate nucleus
Molecular Metabolism, 2017 Objectives: Phytocannabinoids, such as THC and endocannabinoids, are well known to promote feeding behavior and to control energy metabolism through cannabinoid type 1 receptors (CB1R).
Yury M. Morozov +3 more
doaj +1 more source
eLife, 2023 Fatty acid amide hydrolase (FAAH) degrades the endocannabinoid anandamide. A polymorphism in FAAH (FAAH C385A) reduces FAAH expression, increases anandamide levels, and increases the risk of obesity.
Georgia Balsevich +14 more
doaj +1 more source
Non-Contiguous Protein Recombination [PDF]
, 2013 Swapping sequence elements among related proteins can produce chimeric proteins with novel behaviors and improved properties such as enhanced stability. Although homologous mutations are much more conservative than random mutations, chimeras of distantly-
Smith, Matthew Alexander
core +1 more source
PGC-1α expression in murine AgRP neurons regulates food intake and energy balance
Molecular Metabolism, 2016 Objective: Food intake and whole-body energy homeostasis are controlled by agouti-related protein (AgRP) and pro-opiomelanocortin (POMC) neurons located in the arcuate nucleus of the hypothalamus.
Jonathan F. Gill +3 more
doaj +1 more source
Melanocortin receptor accessory proteins in adrenal disease and obesity [PDF]
, 2015 This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the ...
Shwetha Ramachandrappa +11 more
core +1 more source
Effect of endurance training on plasma levels of AGRP and HOMA-IR in diabetic rats
Turkish Journal of Kinesiology, 2017 The hypothalamus is a strong central controller of appetite that secretes different neuropeptides including AGRP. Plasma levels of AGRP are effective in controlling obesity and hunger.
Javad Mehrabani +4 more
doaj +2 more sources
Genetic characterization of coat color genes in Brazilian Crioula sheep from a conservation nucleus [PDF]
Pesquisa Agropecuária Brasileira, 2017 : The objective of this work was to identify single nucleotide polymorphisms (SNPs) in resequencing data from MC1R, ASIP, and TYRP1 genes derived from Crioula sheep (Ovis aris) with different coat colors.
Lilian Cristina Gomes Cavalcanti +7 more
doaj +1 more source
, 2009 Melanocortin-1 receptor (MC1R) and its ligands, a-melanocyte stimulating hormone (aMSH) and agouti signaling protein (ASIP), regulate switching between eumelanin and pheomelanin synthesis in melanocytes.
Bennett, DC +36 more
core +1 more source