Agouti-related protein-deficient mice display an age-related lean phenotype [PDF]
Cell Metabolism, 2005 Endogenous modulators of the central melanocortin system, such as the agouti-related protein (AgRP), should hold a pivotal position in the regulation of energy intake and expenditure. Despite this, AgRP-deficient mice were recently reported to exhibit normal food intake, body weight gain, and energy expenditure.
Wortley, Katherine E. +8 more
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The high glycemic index diet was an independent predictor to explain changes in agouti-related protein in obese adolescents [PDF]
Nutrición Hospitalaria, 2014 The high glycemic index diet was an independent predictor to explain changes in agouti-related protein in obese adolescents. Background & Aims: The role of diet glycemic index (GI) in the control of orexigenic and anorexigenic factors of the energy ...
Bárbara Dal Molin Netto +9 more
doaj +3 more sources
Agouti and Agouti-related Protein: Analogies and Contrasts [PDF]
Journal of Biological Chemistry, 2000 D M, Dinulescu, R D, Cone
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Plasma Agouti-Related Protein and Cortisol Levels in Cushing Disease: Evidence for the Regulation of Agouti-Related Protein by Glucocorticoids in Humans. [PDF]
J Clin Endocrinol Metab, 2019 AbstractContextGlucocorticoids regulate energy balance, in part by stimulating the orexigenic neuropeptide agouti-related protein (AgRP). AgRP neurons express glucocorticoid receptors, and glucocorticoids have been shown to stimulate AgRP gene expression in rodents.ObjectiveWe sought to determine whether there is a relationship between plasma AgRP and ...
Page-Wilson G +7 more
europepmc +3 more sources
Agouti-related protein prevents self-starvation [PDF]
Molecular Psychiatry, 2003 Food restriction leads to a paradoxical increase in physical activity and further suppression of food intake, such as observed in anorexia nervosa.(1,2) To understand this pathophysiological process, we induced physical hyperactivity and self-starvation in rats by restricting food in the presence of running wheels.
Kas, M.J.H. +3 more
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Agouti-Related Protein Neuron Circuits That Regulate Appetite [PDF]
Neuroendocrinology, 2014 New tools for mapping and manipulating molecularly defined neural circuits have improved the understanding of how the central nervous system regulates appetite. Studies that focused on Agouti-related protein neurons, a starvation-sensitive hypothalamic population, have identified multiple circuit elements that can elicit or suppress feeding behavior ...
Sternson, Scott M., Atasoy, Deniz
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Agouti-Signalling Protein Overexpression Reduces Aggressiveness in Zebrafish
Biology, 2023 Feeding motivation plays a crucial role in food intake and growth. It closely depends on hunger and satiation, which are controlled by the melanocortin system.
Ana Rocha +3 more
doaj +1 more source
Differential Signaling Profiles of MC4R Mutations with Three Different Ligands [PDF]
, 2020 The melanocortin 4 receptor (MC4R) is a key player in hypothalamic weight regulation and energy expenditure as part of the leptin-melanocortin pathway. Mutations in this G protein coupled receptor (GPCR) are the most common cause for monogenetic obesity,
Annibale, Paolo +8 more
core +3 more sources
Dmbx1 is essential in agouti-related protein action [PDF]
Proceedings of the National Academy of Sciences, 2007 Dmbx1 is a paired-class homeodomain transcription factor. We show here that mice deficient in Dmbx1 exhibit severe leanness associated with hypophagia and hyperactivity and that isolation of a Dmbx1 −/− mouse from its cohabitants induces self-starvation, sometimes leading to death,
Wakako, Fujimoto +9 more
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Characterization of Agouti-Related Protein Binding to Melanocortin Receptors [PDF]
Molecular Endocrinology, 1999 Agouti-related protein (AGRP) is a naturally occurring antagonist of melanocortin action that is thought to play an important role in the hypothalamic control of feeding behavior. The exact mechanism of AGRP and Agouti protein action has been difficult to examine, in part because of difficulties in producing homogeneous forms of these molecules that ...
Y K, Yang +6 more
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