Results 11 to 20 of about 339,684 (208)

Agouti-related protein prevents self-starvation [PDF]

Molecular Psychiatry, 2003
Food restriction leads to a paradoxical increase in physical activity and further suppression of food intake, such as observed in anorexia nervosa.(1,2) To understand this pathophysiological process, we induced physical hyperactivity and self-starvation in rats by restricting food in the presence of running wheels.
Kas, M.J.H., van Dijk, G, Scheurink, A J W, Adan, Roger A.H.   +3 more
openaire   +3 more sources

Agouti-Related Protein Neuron Circuits That Regulate Appetite [PDF]

Neuroendocrinology, 2014
New tools for mapping and manipulating molecularly defined neural circuits have improved the understanding of how the central nervous system regulates appetite. Studies that focused on Agouti-related protein neurons, a starvation-sensitive hypothalamic population, have identified multiple circuit elements that can elicit or suppress feeding behavior ...
Sternson, Scott M., Atasoy, Deniz
openaire   +4 more sources

Effect of eight weeks aerobic exercise on plasma level of agouti-related protein, glycated hemoglobin and glucose in non-active type II diabetic women

مجله دانشگاه علوم پزشکی گرگان, 2015
Background and Objective: Diabetes mellitus is the most common type of metabolic diseases which is characterized with hyperglycemia due to implicit or relative insulin deficiency. Diabetes mellitus is acutely related to obesity.
Ghiasi E, Dabbagh Manesh MH, Daryanoosh F, Nazemzadeghan Gh   +3 more
doaj   +1 more source

Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression [PDF]

Neurosignals, 2012
Activation of mammalian target of rapamycin 1 (mTORC1) by nutrients, insulin and leptin leads to appetite suppression (anorexia). Contrastingly, increased AMP-activated protein kinase (AMPK) activity by ghrelin promotes appetite (orexia).
Kenneth R. Watterson, Dawn Bestow, Jennifer Gallagher, D. Lee Hamilton, Fiona B. Ashford, Paul J. Meakin, Michael L.J. Ashford   +6 more
doaj   +2 more sources

Structural and Molecular Evolutionary Analysis of Agouti and Agouti-Related Proteins

Chemistry & Biology, 2006
Agouti (ASIP) and Agouti-related protein (AgRP) are endogenous antagonists of melanocortin receptors that play critical roles in the regulation of pigmentation and energy balance, respectively, and which arose from a common ancestral gene early in vertebrate evolution.
Jackson, Pilgrim J., Douglas, Nick R., Chai, Biaoxin, Binkley, Jonathan, Sidow, Arend, Barsh, Gregory S., Millhauser, Glenn L.   +6 more
openaire   +3 more sources

Altered responses to ghrelin and food cues in AgRP neurons during pregnancy and lactation. [PDF]

J Neuroendocrinol
Abstract Pregnancy and lactation trigger many metabolic adaptations, including increased food intake to support the energy demands of the growing foetus and then to provide nutrition through milk production after birth. Ghrelin, an orexigenic hormone, activates agouti related peptide (AgRP) neurons in the arcuate nucleus to promote food intake.
Murrell CL, Perkinson MR, Andrews ZB, Grattan DR, Ladyman SR.   +4 more
europepmc   +2 more sources

Integration of Nutrient Sensing in Fish Hypothalamus

Frontiers in Neuroscience, 2021
The knowledge regarding hypothalamic integration of metabolic and endocrine signaling resulting in regulation of food intake is scarce in fish. Available studies pointed to a network in which the activation of the nutrient-sensing (glucose, fatty acid ...
José L. Soengas
doaj   +1 more source

Does an acute bout of high intensity interval exercise suppress appetite in obese women?

Pedagogy of Physical Culture and Sports, 2020
Purpose: The aim of this study was to investigate the 24 hour response of appetite and energy intake and the amount of Agouti-Related Protein to the high intensity interval exercise in obese untrained women.
Sepideh Khalaj, Bahman Mirzaei
doaj   +1 more source

Dmbx1 is essential in agouti-related protein action [PDF]

Proceedings of the National Academy of Sciences, 2007
Dmbx1 is a paired-class homeodomain transcription factor. We show here that mice deficient in Dmbx1 exhibit severe leanness associated with hypophagia and hyperactivity and that isolation of a Dmbx1 −/− mouse from its cohabitants induces self-starvation, sometimes leading to death,
Wakako, Fujimoto, Tetsuya, Shiuchi, Takashi, Miki, Yasuhiko, Minokoshi, Yoshihisa, Takahashi, Ayako, Takeuchi, Kazuhiro, Kimura, Masayuki, Saito, Toshihiko, Iwanaga, Susumu, Seino   +9 more
openaire   +2 more sources

Characterization of Agouti-Related Protein Binding to Melanocortin Receptors [PDF]

Molecular Endocrinology, 1999
Agouti-related protein (AGRP) is a naturally occurring antagonist of melanocortin action that is thought to play an important role in the hypothalamic control of feeding behavior. The exact mechanism of AGRP and Agouti protein action has been difficult to examine, in part because of difficulties in producing homogeneous forms of these molecules that ...
Y K, Yang, D A, Thompson, C J, Dickinson, J, Wilken, G S, Barsh, S B, Kent, I, Gantz   +6 more
openaire   +3 more sources