Results 21 to 30 of about 12,122 (173)

mTORC1 Signaling in AgRP Neurons Is Not Required to Induce Major Neuroendocrine Adaptations to Food Restriction

open access: yesCells, 2023
Hypothalamic mTORC1 signaling is involved in nutrient sensing. Neurons that express the agouti-related protein (AgRP) are activated by food restriction and integrate interoceptive and exteroceptive signals to control food intake, energy expenditure, and ...
Gabriel O. de Souza   +3 more
doaj   +1 more source

Malocclusion impairs cognitive behavior via AgRP signaling in adolescent mice

open access: yesFrontiers in Neuroscience, 2023
IntroductionOcclusal disharmony induced by deteriorating oral health conditions, such as tooth loss and decreased masticatory muscle due to sarcopenia, is one of the causes of cognitive impairment.
Junya Kusumoto   +9 more
doaj   +1 more source

Integration of Nutrient Sensing in Fish Hypothalamus

open access: yesFrontiers in Neuroscience, 2021
The knowledge regarding hypothalamic integration of metabolic and endocrine signaling resulting in regulation of food intake is scarce in fish. Available studies pointed to a network in which the activation of the nutrient-sensing (glucose, fatty acid ...
José L. Soengas
doaj   +1 more source

Does an acute bout of high intensity interval exercise suppress appetite in obese women?

open access: yesPedagogy of Physical Culture and Sports, 2020
Purpose: The aim of this study was to investigate the 24 hour response of appetite and energy intake and the amount of Agouti-Related Protein to the high intensity interval exercise in obese untrained women.
Sepideh Khalaj, Bahman Mirzaei
doaj   +1 more source

Dmbx1 is essential in agouti-related protein action [PDF]

open access: yesProceedings of the National Academy of Sciences, 2007
Dmbx1 is a paired-class homeodomain transcription factor. We show here that mice deficient in Dmbx1 exhibit severe leanness associated with hypophagia and hyperactivity and that isolation of a Dmbx1 −/− mouse from its cohabitants ...
Wakako, Fujimoto   +9 more
openaire   +2 more sources

Agouti-related protein prevents self-starvation [PDF]

open access: yesMolecular Psychiatry, 2003
Food restriction leads to a paradoxical increase in physical activity and further suppression of food intake, such as observed in anorexia nervosa.(1,2) To understand this pathophysiological process, we induced physical hyperactivity and self-starvation in rats by restricting food in the presence of running wheels.
Kas, M.J.H.   +3 more
openaire   +2 more sources

Characterization of Agouti-Related Protein Binding to Melanocortin Receptors [PDF]

open access: yesMolecular Endocrinology, 1999
Agouti-related protein (AGRP) is a naturally occurring antagonist of melanocortin action that is thought to play an important role in the hypothalamic control of feeding behavior. The exact mechanism of AGRP and Agouti protein action has been difficult to examine, in part because of difficulties in producing homogeneous forms of these molecules that ...
Y K, Yang   +6 more
openaire   +3 more sources

Agouti revisited: transcript quantification of the ASIP gene in bovine tissues related to protein expression and localization. [PDF]

open access: yesPLoS ONE, 2012
Beside its role in melanogenesis, the agouti signaling protein (ASIP) has been related to obesity. The potentially crucial role in adipocyte development makes it a tempting candidate for economic relevant, fat related traits in farm animals.
Elke Albrecht   +3 more
doaj   +1 more source

Agouti-Related Protein Neuron Circuits That Regulate Appetite [PDF]

open access: yesNeuroendocrinology, 2014
New tools for mapping and manipulating molecularly defined neural circuits have improved the understanding of how the central nervous system regulates appetite. Studies that focused on Agouti-related protein neurons, a starvation-sensitive hypothalamic population, have identified multiple circuit elements that can elicit or suppress feeding behavior ...
Sternson, Scott M., Atasoy, Deniz
openaire   +2 more sources

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