Results 21 to 30 of about 339,684 (208)

Agouti-Signalling Protein Overexpression Reduces Aggressiveness in Zebrafish

Biology, 2023
Feeding motivation plays a crucial role in food intake and growth. It closely depends on hunger and satiation, which are controlled by the melanocortin system.
Ana Rocha, Alejandra Godino-Gimeno, Josep Rotllant, José Miguel Cerdá-Reverter   +3 more
doaj   +1 more source

Agouti revisited: transcript quantification of the ASIP gene in bovine tissues related to protein expression and localization. [PDF]

PLoS ONE, 2012
Beside its role in melanogenesis, the agouti signaling protein (ASIP) has been related to obesity. The potentially crucial role in adipocyte development makes it a tempting candidate for economic relevant, fat related traits in farm animals.
Elke Albrecht, Katrin Komolka, Judith Kuzinski, Steffen Maak   +3 more
doaj   +1 more source

Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances [PDF]

, 2007
The hypothalamic melanocortin system is crucial for the control of appetite and body weight. Two of the five melanocortin receptors, MC3R and MC4R are involved in hypothalamic control of energy homeostasis, with the MC4R having the major influence. It is
Hisadome, Kazunari, Michael L. J. Ashford, Smith, Mark A., Helen Heffron, Mark A. Smith, Al-Qassab, Hind, Kazunari Hisadome, Withers, Dominic J., Hind Al‐Qassab, Dominic J. Withers, Ashford, Michael L. J.; id_orcid, Heffron, Helen   +11 more
core   +1 more source

Understanding how discrete populations of hypothalamic neurons orchestrate complicated behavioral states

Frontiers in Systems Neuroscience, 2015
A major question in systems neuroscience is how a single population of neurons can interact with the rest of the brain to orchestrate complex behavioral states. The hypothalamus contains many such discrete neuronal populations that individually regulate
Allison eGraebner, Manasi eIyer, Matthew Evan Carter   +2 more
doaj   +1 more source

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons [PDF]

, 2007
Hypothalamic AMP-activated protein kinase (AMPK) has been suggested to act as a key sensing mechanism, responding to hormones and nutrients in the regulation of energy homeostasis.
Carling, D., Choudhury, Agharul I., Smith, Mark A., Fryer, L.G.D., Speakman, J.R., Ashford, MLJ, Carling, D, Withers, DJ, Selman, Colin, Xu, Allison W., Al-Qassab, H, Fryer, Lee G.D., Vaulont, Sophie, Choudhury, AI, Fryer, LGD, Vaulont, S., Claret, Marc, Heffron, H, Speakman, John R., Heffron, H., Barsh, Gregory S., Clements, M, Choudhury, A.I., Vaulont, S, Heffron, Helen, Xu, A.W., Withers, D.J., Viollet, B, Smith, MA, Barsh, G.S., Clements, Melanie, Withers, Dominic J., Viollet, B., Ashford, Michael L. J.; id_orcid, Batterham, RL, Selman, C, Claret, M., Barsh, GS, Claret, M, Selman, C., Al-Qassab, H., Xu, AW, Al-Qassab, Hind, Viollet, Benoit, Smith, M.A., Ashford, M.L.J., Batterham, R.L., Batterham, Rachel L., Carling, David, Speakman, JR, Clements, M.   +50 more
core   +1 more source

The role of melanocortins and cytokines in human adipose tissue and adipocytes [PDF]

, 2007
During the last decades obesity has become a major health problem in developed countries, and more recently also in the developing countries it is seriously affecting parts of the populations.
Hoch, Matthias
core   +1 more source

Role of Agouti-Related Protein-Expressing Neurons in Lactation [PDF]

Endocrinology, 2007
Hypothalamic neurons that express agouti-related protein (AgRP) and neuropeptide Y (NPY) are thought to be important for regulation of feeding, especially under conditions of negative energy balance. The expression of NPY and AgRP increases during lactation and may promote the hyperphagia that ensues.
Colin T, Phillips, Richard D, Palmiter
openaire   +2 more sources

Effect of 24 h Fasting on Gene Expression of AMPK, Appetite Regulation Peptides and Lipometabolism Related Factors in the Hypothalamus of Broiler Chicks [PDF]

Asian-Australasian Journal of Animal Sciences, 2012
The 5’-adenosine monophosphate-activated protein kinase (AMPK) is a key part of a kinase-signaling cascade that acts to maintain energy homeostasis. The objective of this experiment was to investigate the possible effects of fasting and refeeding on the ...
Liu Lei, Zhu Lixian
doaj   +1 more source

Role of Hypothalamic Transforming Growth Factor-β (TGF-β)/Smad Signaling in Feeding Regulation in Chickens

The Journal of Poultry Science, 2022
Previous studies in mammalian obesity models have suggested that central transforming growth factor-β (TGF-β) controls the gene expression of appetite-regulating neuropeptides and peripheral energy metabolism.
Takaoki Saneyasu, Miku Ueda, Kanami Nagata, Jiawei Chai, Kazuhisa Honda, Hiroshi Kamisoyama   +5 more
doaj   +1 more source

AgRP neurons are not indispensable for body weight maintenance in adult mice

Cell Reports, 2023
Summary: In addition to their role in promoting feeding and obesity development, hypothalamic arcuate agouti-related protein/neuropeptide Y (AgRP/NPY) neurons are widely perceived to be indispensable for maintaining normal feeding and body weight in ...
Jing Cai, Jing Chen, Joshua Ortiz-Guzman, Jessica Huang, Benjamin R. Arenkiel, Yuchen Wang, Yan Zhang, Yuyan Shi, Qingchun Tong, Cheng Zhan   +9 more
doaj   +1 more source