Results 1 to 10 of about 9,606 (201)
Agouti Signaling Protein and Its Receptors as Potential Molecular Markers for Intramuscular and Body Fat Deposition in Cattle [PDF]
Frontiers in Physiology, 2018 Transcriptome analyses of bovine muscle tissue differing in intramuscular fat (IMF) content identified agouti signaling protein (ASIP) as a promising candidate gene for fat deposition.
Yinuo Liu +7 more
doaj +4 more sources
Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity. [PDF]
Nat Metab, 2022 Here we report a heterozygous tandem duplication at the ASIP (agouti signaling protein) gene locus causing ubiquitous, ectopic ASIP expression in a female patient with extreme childhood obesity.
Kempf E +17 more
europepmc +5 more sources
Atypical Genotypes for Canine Agouti Signaling Protein Suggest Novel Chromosomal Rearrangement. [PDF]
Genes (Basel), 2020 Canine coat color is a readily observed phenotype of great interest to dog enthusiasts; it is also an excellent avenue to explore the mechanisms of genetics and inheritance. As such, multiple commercial testing laboratories include basic color alleles in
Dreger DL +6 more
europepmc +5 more sources
Chemical disulfide mapping identifies an inhibitor cystine knot in the agouti signaling protein [PDF]
FEBS Letters, 2007 The agouti signaling protein (ASIP) and its homolog, the agouti-related protein (AgRP), act as inverse agonists that control, respectively, pigmentation and metabolic function in mammals.
Glenn L Millhauser
exaly +4 more sources
American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 2001 Agouti signaling protein (ASIP), the human (h) homolog of agouti, is an endogenous melanocortin peptide antagonist. To date, characterization of this protein has been performed with recombinant protein only and without the availability of an ASIP/agouti ...
Ying-Kui Yang +2 more
exaly +4 more sources
Experimental Biology and Medicine, 2001 Ectopic overexpression of the murine agouti gene results in yellow coat color, obesity, hyperinsulinemia, and type II diabetes. We have shown the human homologue of agouti (agouti signaling protein; ASP) to regulate human adipocyte metabolism and lipid ...
Bingzhong Xue, Michael B Zemel
exaly +4 more sources
The Journal of Poultry Science, 2010 The agouti signaling protein (ASIP)/melanocortin signaling system regulates lipid metabolism in humans but not in mice. To examine whether the system is present in adipose tissues in chickens, we performed reverse transcription-polymerase chain reaction
Masafumi Yabuuchi +4 more
doaj +2 more sources
Melanism in peromyscus is caused by independent mutations in agouti. [PDF]
PLoS ONE, 2009 Identifying the molecular basis of phenotypes that have evolved independently can provide insight into the ways genetic and developmental constraints influence the maintenance of phenotypic diversity.
Evan P Kingsley +3 more
doaj +3 more sources
Blocking ASIP to Protect MC1R Signaling and Mitigate Melanoma Risk: An In Silico Study [PDF]
PharmaceuticalsBackground: Melanin protects skin and hair from the effects of ultraviolet (UV) radiation damage, which contributes to all forms of skin cancer, including melanoma.
Farah Maarfi +3 more
doaj +2 more sources
Glucose Intake during the Neonatal Period Modulates the Central Melanocortin System with Breed-Specific Differences [PDF]
The Journal of Poultry ScienceGlucose is the primary substrate for cellular energy production, and its blood concentration is tightly regulated. This study investigated the effect of glucose supplementation during the first three days post-hatching on growth performance and ...
Kazuki Kimura +6 more
doaj +2 more sources