Results 1 to 10 of about 17,072 (187)

Atypical Genotypes for Canine Agouti Signaling Protein Suggest Novel Chromosomal Rearrangement. [PDF]

Genes (Basel), 2020
Canine coat color is a readily observed phenotype of great interest to dog enthusiasts; it is also an excellent avenue to explore the mechanisms of genetics and inheritance. As such, multiple commercial testing laboratories include basic color alleles in their popular screening panels, allowing for the creation of genotyped datasets at a scale not ...
Dreger DL, Anderson H, Donner J, Clark JA, Dykstra A, Hughes AM, Ekenstedt KJ.   +6 more
europepmc   +4 more sources

Agouti Signaling Protein and Its Receptors as Potential Molecular Markers for Intramuscular and Body Fat Deposition in Cattle [PDF]

Frontiers in Physiology, 2018
Transcriptome analyses of bovine muscle tissue differing in intramuscular fat (IMF) content identified agouti signaling protein (ASIP) as a promising candidate gene for fat deposition.
Yinuo Liu, Yinuo Liu, Elke Albrecht, Lisa Schering, Christa Kuehn, Runjun Yang, Zhihui Zhao, Steffen Maak   +7 more
doaj   +2 more sources

Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity. [PDF]

Nat Metab, 2022
Abstract Here we report a heterozygous tandem duplication at the ASIP (agouti signaling protein) gene locus causing ubiquitous, ectopic ASIP expression in a female patient with extreme childhood obesity. The mutation places
Kempf E, Landgraf K, Stein R, Hanschkow M, Hilbert A, Abou Jamra R, Boczki P, Herberth G, Kühnapfel A, Tseng YH, Stäubert C, Schöneberg T, Kühnen P, Rayner NW, Zeggini E, Kiess W, Blüher M, Körner A.   +17 more
europepmc   +5 more sources

Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective [PDF]

Frontiers in Endocrinology, 2019
The melanocortin-4 receptor (MC4R) can be endogenously activated by binding of melanocyte-stimulating hormones (MSH), which mediates anorexigenic effects. In contrast, the agouti-related peptide (AgRP) acts as an endogenous inverse agonist and suppresses
Nicolas Heyder, Gunnar Kleinau, Michal Szczepek, Dennis Kwiatkowski, David Speck, Lucia Soletto, José Miguel Cerdá-Reverter, Heiko Krude, Peter Kühnen, Heike Biebermann, Patrick Scheerer   +10 more
doaj   +3 more sources

Blocking ASIP to Protect MC1R Signaling and Mitigate Melanoma Risk: An In Silico Study [PDF]

Pharmaceuticals
Background: Melanin protects skin and hair from the effects of ultraviolet (UV) radiation damage, which contributes to all forms of skin cancer, including melanoma.
Farah Maarfi, Mohammed Cherkaoui, Sana Afreen, Mohd Yasir Khan   +3 more
doaj   +2 more sources

Glucose Intake during the Neonatal Period Modulates the Central Melanocortin System with Breed-Specific Differences [PDF]

The Journal of Poultry Science
Glucose is the primary substrate for cellular energy production, and its blood concentration is tightly regulated. This study investigated the effect of glucose supplementation during the first three days post-hatching on growth performance and ...
Kazuki Kimura, Yuuna Watanabe, Sachi Ashizawa, Koichi Matsushita, Nobuhiro Nakao, Yoshiyuki Ohta, Jun-ichi Shiraishi   +6 more
doaj   +2 more sources

Local Agouti Signaling Protein/Melanocortin Signaling System that Possibly Regulates Lipid Metabolism in Adipose Tissues of Chickens

The Journal of Poultry Science, 2010
The agouti signaling protein (ASIP)/melanocortin signaling system regulates lipid metabolism in humans but not in mice. To examine whether the system is present in adipose tissues in chickens, we performed reverse transcription-polymerase chain reaction
Masafumi Yabuuchi, Kana Bando, Misato Hiramatsu, Sumio Takahashi, Sakae Takeuchi   +4 more
doaj   +3 more sources

Integration of Nutrient Sensing in Fish Hypothalamus

Frontiers in Neuroscience, 2021
The knowledge regarding hypothalamic integration of metabolic and endocrine signaling resulting in regulation of food intake is scarce in fish. Available studies pointed to a network in which the activation of the nutrient-sensing (glucose, fatty acid ...
José L. Soengas
doaj   +1 more source

Effects of Recombinant Agouti-Signaling Protein on Melanocortin Action [PDF]

Molecular Endocrinology, 1997
Mouse agouti protein is a paracrine signaling molecule that has previously been demonstrated to be an antagonist of melanocortin action at several cloned rodent and human melanocortin receptors. In this study we report the effects of agouti-signaling protein (ASIP), the human homolog of mouse agouti, on the action of alpha-MSH or ACTH at the five known
Y K, Yang, M M, Ollmann, B D, Wilson, C, Dickinson, T, Yamada, G S, Barsh, I, Gantz   +6 more
openaire   +3 more sources

Role of the Melanocortin System in Gonadal Steroidogenesis of Zebrafish

Animals, 2022
In teleost, as in other vertebrates, stress affects reproduction. A key component of the stress response is the pituitary secretion of the adrenocorticotropic hormone (ACTH), which binds to the melanocortin 2 receptor (MC2R) in the adrenal glands and ...
Sandra Navarro, Diego Crespo, Rüdiger W. Schulz, Wei Ge, Josep Rotllant, José Miguel Cerdá-Reverter, Ana Rocha   +6 more
doaj   +1 more source