Results 21 to 30 of about 959,384 (214)

A missense mutation in the agouti signaling protein gene (ASIP) is associated with the no light points coat phenotype in donkeys. [PDF]

Genet Sel Evol, 2015
Seven donkey breeds are recognized by the French studbook and are characterized by a black, bay or grey coat colour including light cream-to-white points (LP).
Abitbol M, Legrand R, Tiret L.
europepmc   +2 more sources

Effects of Recombinant Agouti-Signaling Protein on Melanocortin Action [PDF]

Molecular Endocrinology, 1997
Mouse agouti protein is a paracrine signaling molecule that has previously been demonstrated to be an antagonist of melanocortin action at several cloned rodent and human melanocortin receptors. In this study we report the effects of agouti-signaling protein (ASIP), the human homolog of mouse agouti, on the action of alpha-MSH or ACTH at the five known
Ying-Kui Yang, Michael M Ollmann, Brent D Wilson   +2 more
exaly   +4 more sources

Local Agouti Signaling Protein/Melanocortin Signaling System that Possibly Regulates Lipid Metabolism in Adipose Tissues of Chickens

The Journal of Poultry Science, 2010
The agouti signaling protein (ASIP)/melanocortin signaling system regulates lipid metabolism in humans but not in mice. To examine whether the system is present in adipose tissues in chickens, we performed reverse transcription-polymerase chain reaction
Masafumi Yabuuchi, Kana Bando, Misato Hiramatsu, Sumio Takahashi, Sakae Takeuchi   +4 more
doaj   +2 more sources

Blocking ASIP to Protect MC1R Signaling and Mitigate Melanoma Risk: An In Silico Study [PDF]

Pharmaceuticals
Background: Melanin protects skin and hair from the effects of ultraviolet (UV) radiation damage, which contributes to all forms of skin cancer, including melanoma.
Farah Maarfi, Mohammed Cherkaoui, Sana Afreen, Mohd Yasir Khan   +3 more
doaj   +2 more sources

Lack of polymorphism of the agouti signaling protein (ASIP) gene among four different brown hare (Lepus europaeus Pallas 1778) populations

, 2016
SUMMARY The brown hare ( Lepus europaeus Pallas 1778) is a common palearctic and a popular game species therefore it has been an obvious subject for population genetic studies since the second part of the 20 th century.
Noémi Soós, S. Kusza
semanticscholar   +2 more sources

Glucose Intake during the Neonatal Period Modulates the Central Melanocortin System with Breed-Specific Differences [PDF]

The Journal of Poultry Science
Glucose is the primary substrate for cellular energy production, and its blood concentration is tightly regulated. This study investigated the effect of glucose supplementation during the first three days post-hatching on growth performance and ...
Kazuki Kimura, Yuuna Watanabe, Sachi Ashizawa, Koichi Matsushita, Nobuhiro Nakao, Yoshiyuki Ohta, Jun-ichi Shiraishi   +6 more
doaj   +2 more sources

Loop Swapped Chimeras of the Agouti-related Protein (AgRP) and the Agouti Signaling Protein (ASIP) Identify Contacts Required for Melanocortin 1 Receptor (MC1R) Selectivity and Antagonism [PDF]

Journal of Molecular Biology, 2010
Agouti related protein (AgRP) and agouti signaling protein (ASIP) are homologs that play critical roles in energy balance and pigmentation, respectively, by functioning as antagonistic ligands at their cognate melanocortin receptors (MCRs).
Mira P. Patel, C. C. Fabersunne, Ying-kui Yang, C. Kaelin, G. Barsh, G. Millhauser   +5 more
semanticscholar   +3 more sources

Defining MC1R Regulation in Human Melanocytes by Its Agonist α-Melanocortin and Antagonists Agouti Signaling Protein and β-Defensin 3

Journal of Investigative Dermatology, 2012
The melanocortin 1 receptor (MC1R), a Gs protein-coupled receptor, plays an important role in human pigmentation. We investigated the regulation of expression and activity of the MC1R in primary human melanocyte cultures.
V. Swope, J. Jameson, Kevin McFarland, D. Supp, W. Miller, D. McGraw, M. A. Patel, M. Nix, G. Milhauser, G. Babcock, Z. Abdel‐Malek   +10 more
semanticscholar   +2 more sources

Agouti-Signalling Protein Overexpression Reduces Aggressiveness in Zebrafish

Biology, 2023
Feeding motivation plays a crucial role in food intake and growth. It closely depends on hunger and satiation, which are controlled by the melanocortin system. Overexpression of the inverse agonist agouti-signalling protein (ASIP) and agouti-related protein (AGRP) leads to enhanced food intake, linear growth, and weight. In zebrafish, overexpression of
Ana Rocha, Alejandra Godino-Gimeno, Josep Rotllant, José Miguel Cerdá-Reverter   +3 more
openaire   +4 more sources

Modulation of murine melanocyte function invitro by agouti signal protein [PDF]

The EMBO Journal, 1997
Molecular and biochemical mechanisms that switch melanocytes between the production of eumelanin or pheomelanin involve the opposing action of two intercellular signaling molecules, alpha-melanocyte-stimulating hormone (MSH) and agouti signal protein (ASP).
C, Sakai, M, Ollmann, T, Kobayashi, Z, Abdel-Malek, J, Muller, W D, Vieira, G, Imokawa, G S, Barsh, V J, Hearing   +8 more
openaire   +2 more sources