Results 31 to 40 of about 959,384 (214)

Physiological and Anatomical Circuitry between Agouti-Related Protein and Leptin Signaling* [PDF]

Endocrinology, 1999
Agouti-related protein (AGRP) is an orexigenic neuropeptide that acts via central melanocortin receptors, and whose messenger RNA (mRNA) levels are elevated in leptin-deficient mice. Fasting associated with a decline in circulating leptin normally causes a 15-fold elevation of hypothalamic Agrp mRNA levels but has no effect in leptin-deficient mice ...
B D, Wilson, D, Bagnol, C B, Kaelin, M M, Ollmann, I, Gantz, S J, Watson, G S, Barsh   +6 more
openaire   +2 more sources

Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances [PDF]

, 2007
The hypothalamic melanocortin system is crucial for the control of appetite and body weight. Two of the five melanocortin receptors, MC3R and MC4R are involved in hypothalamic control of energy homeostasis, with the MC4R having the major influence. It is
Hisadome, Kazunari, Michael L. J. Ashford, Smith, Mark A., Helen Heffron, Mark A. Smith, Al-Qassab, Hind, Kazunari Hisadome, Withers, Dominic J., Hind Al‐Qassab, Dominic J. Withers, Ashford, Michael L. J.; id_orcid, Heffron, Helen   +11 more
core   +1 more source

Melanocortin 1 Receptor: Structure, Function and Regulation

Frontiers in Genetics, 2016
The melanocortin 1 receptor (MC1R) is a melanocytic Gs protein coupled receptor that regulates skin pigmentation, UV responses, and melanoma risk. It is a highly polymorphic gene, and loss of function correlates with a fair, UV-sensitive, and melanoma ...
Erin Marissa Wolf Horrell, Mary Catherine Boulanger, John August D'orazio   +2 more
doaj   +1 more source

Genetic characterization of coat color genes in Brazilian Crioula sheep from a conservation nucleus [PDF]

Pesquisa Agropecuária Brasileira, 2017
: The objective of this work was to identify single nucleotide polymorphisms (SNPs) in resequencing data from MC1R, ASIP, and TYRP1 genes derived from Crioula sheep (Ovis aris) with different coat colors.
Lilian Cristina Gomes Cavalcanti, José Carlos Ferrugem Moraes, Danielle Assis de Faria, Concepta Margaret McManus, Alcebiades Renato Nepomuceno, Carlos José Hoff de Souza, Alexandre Rodrigues Caetano, Samuel Rezende Paiva   +7 more
doaj   +1 more source

PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure. [PDF]

PLoS ONE, 2011
Insulin and leptin intracellular signaling pathways converge and act synergistically on the hypothalamic phosphatidylinositol-3-OH kinase/3-phosphoinositide-dependent protein kinase 1 (PDK1).
Yongheng Cao, Masanori Nakata, Shiki Okamoto, Eisuke Takano, Toshihiko Yada, Yasuhiko Minokoshi, Yukio Hirata, Kazunori Nakajima, Kristy Iskandar, Yoshitake Hayashi, Wataru Ogawa, Gregory S Barsh, Hiroshi Hosoda, Kenji Kangawa, Hiroshi Itoh, Tetsuo Noda, Masato Kasuga, Jun Nakae   +17 more
doaj   +1 more source

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons [PDF]

, 2007
Hypothalamic AMP-activated protein kinase (AMPK) has been suggested to act as a key sensing mechanism, responding to hormones and nutrients in the regulation of energy homeostasis.
Carling, D., Choudhury, Agharul I., Smith, Mark A., Fryer, L.G.D., Speakman, J.R., Ashford, MLJ, Carling, D, Withers, DJ, Selman, Colin, Xu, Allison W., Al-Qassab, H, Fryer, Lee G.D., Vaulont, Sophie, Choudhury, AI, Fryer, LGD, Vaulont, S., Claret, Marc, Heffron, H, Speakman, John R., Heffron, H., Barsh, Gregory S., Clements, M, Choudhury, A.I., Vaulont, S, Heffron, Helen, Xu, A.W., Withers, D.J., Viollet, B, Smith, MA, Barsh, G.S., Clements, Melanie, Withers, Dominic J., Viollet, B., Ashford, Michael L. J.; id_orcid, Batterham, RL, Selman, C, Claret, M., Barsh, GS, Claret, M, Selman, C., Al-Qassab, H., Xu, AW, Al-Qassab, Hind, Viollet, Benoit, Smith, M.A., Ashford, M.L.J., Batterham, R.L., Batterham, Rachel L., Carling, David, Speakman, JR, Clements, M.   +50 more
core   +1 more source

Cardiometabolic Consequences of Deleting the Regulator of G protein Signaling-2 (Rgs2) from Cells Expressing Agouti-Related Peptide or the Angiotensin II Type 1A Receptor in Mice

HYPERTENSION, 2022
Background: RGS (regulator of G protein signaling) family members catalyze the termination of G protein signaling cascades. Single nucleotide polymorphisms in the RGS2 gene in humans have been linked to hypertension, preeclampsia, and anxiety disorders ...
McKenzie L Ritter, G. Deng, John J Reho, Yue Deng, Sarah A. Sapouckey, Megan A. Opichka, Kirthikaa Balapattabi, Kelsey K Wackman, Daniel T. Brozoski, Ko‐ting Lu, W. Paradee, K. Gibson-Corley, Huxing Cui, P. Nakagawa, L. Morselli, C. Sigmund, Justin L. Grobe   +16 more
semanticscholar   +1 more source

The melanocortin receptors and their accessory proteins. [PDF]

, 2013
The five melanocortin receptors (MCRs) named MC1R-MC5R have diverse physiological roles encompassing pigmentation, steroidogenesis, energy homeostasis and feeding behavior as well as exocrine function.
Adrian J. L. Clark, Li eChan, Clark, AJ, Rebecca J. Gorrigan, Shwetha Ramachandrappa, Rebecca eGorrigan, Adrian eClark, Shwetha eRamachandrappa, Ramachandrappa, S, Gorrigan, RJ, Li F. Chan, Chan, LF, Clark, AJL   +12 more
core   +1 more source

Adaptive variation in beach mice produced by two interacting pigmentation genes.

PLoS Biology, 2007
Little is known about the genetic basis of ecologically important morphological variation such as the diverse color patterns of mammals. Here we identify genetic changes contributing to an adaptive difference in color pattern between two subspecies of ...
Cynthia C Steiner, Jesse N Weber, Hopi E Hoekstra   +2 more
doaj   +1 more source

Hypothalamic mTOR signaling mediates the orexigenic action of ghrelin.

PLoS ONE, 2012
Current evidence suggests that ghrelin, a stomach derived peptide, exerts its orexigenic action through specific modulation of Sirtuin1 (SIRT1)/p53 and AMP-activated protein kinase (AMPK) pathways, which ultimately increase the expression of agouti ...
Luís Martins, Diana Fernández-Mallo, Marta G Novelle, María J Vázquez, Manuel Tena-Sempere, Rubén Nogueiras, Miguel López, Carlos Diéguez   +7 more
doaj   +1 more source