Results 31 to 40 of about 9,208 (167)
Involvement of Microphthalmia in the Inhibition of Melanocyte Lineage Differentiation and of Melanogenesis by Agouti Signal Protein [PDF]
Journal of Biological Chemistry, 1998 In mouse follicular melanocytes, production of eumelanins (brown-black pigments) and pheomelanins (yellow-brownish pigments) is under the control of two intercellular signaling molecules that exert opposite actions, alpha-melanocyte-stimulating hormone (alphaMSH) which preferentially increases the synthesis of eumelanins, and agouti signal protein (ASP)
Aberdam, Edith +8 more
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Frontiers in Neuroscience, 2018 Genetic manipulation of teleost endocrine systems started with transgenic overexpression of pituitary growth hormone. Such strategies enhance growth and reduce fertility, but the fish still breed.
Vance L. Trudeau
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Liver Research, 2023 Alcohol-related liver disease (ALD) became an important health issue worldwide. Following chronic alcohol consumption, the development of ALD might be caused by metabolic and immunologic factors, such as reactive oxygen species (ROS) and pro-inflammatory
Tom Ryu +4 more
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Identification of a GABAergic neural circuit governing leptin signaling deficiency-induced obesity
eLife, 2023 The hormone leptin is known to robustly suppress food intake by acting upon the leptin receptor (LepR) signaling system residing within the agouti-related protein (AgRP) neurons of the hypothalamus.
Yong Han +4 more
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Reply to Braasch and Postlethwait: Evolutionary origin of the teleost A2 agouti genes ( agouti signaling protein 2 and agouti-related protein 2 ) remains unclear [PDF]
Proceedings of the National Academy of Sciences, 2011 Tetrapods express one agouti gene [agouti signaling protein (asip)] in the skin regulating pigmentation and a second [agouti-related protein (agrp)] in the brain regulating energy homeostasis. In contrast, most teleosts have four genes encoding agouti-type proteins.
Helgi B. Schiöth +2 more
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Frontiers in Endocrinology, 2019 The melanocortin-4 receptor (MC4R) can be endogenously activated by binding of melanocyte-stimulating hormones (MSH), which mediates anorexigenic effects. In contrast, the agouti-related peptide (AgRP) acts as an endogenous inverse agonist and suppresses
Nicolas Heyder +10 more
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The Alpha-Melanocyte-Stimulating Hormone Suppresses TLR2-Mediated Functional Responses through IRAK-M in Normal Human Keratinocytes. [PDF]
PLoS ONE, 2015 Alpha-melanocyte stimulating hormone (α-MSH) is a highly conserved 13-aa neuropeptide derived from pro-opiomelanocortin by post-translational processing, which has been reported to exhibit potent anti-inflammatory activity and a wide range of ...
Sunhyo Ryu +6 more
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Biomedicines, 2023 Neuronal circuits regulating appetite are dominated by arcuate nucleus neurons, which include appetite-promoting and -suppressing neurons that release the orexigenic neuropeptide agouti-related protein (AgRP) and anorexigenic neuropeptide pro ...
Chiu-Ya Lin +3 more
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Effects of hypothalamic neurodegeneration on energy balance. [PDF]
PLoS Biology, 2005 Normal aging in humans and rodents is accompanied by a progressive increase in adiposity. To investigate the role of hypothalamic neuronal circuits in this process, we used a Cre-lox strategy to create mice with specific and progressive degeneration of ...
Allison Wanting Xu +9 more
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Frontiers in Endocrinology, 2022 The melanocortin system consists of five G protein–coupled receptors (MC1R-MC5R), the bidirectional endogenous ligands (MSH and Agouti families), and accessory proteins (MRAP1 and MRAP2).
Xiaolu Tai +8 more
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