Results 51 to 60 of about 959,384 (214)
Identification of a GABAergic neural circuit governing leptin signaling deficiency-induced obesity
eLife, 2023 The hormone leptin is known to robustly suppress food intake by acting upon the leptin receptor (LepR) signaling system residing within the agouti-related protein (AgRP) neurons of the hypothalamus.
Yong Han +4 more
doaj +1 more source
, 2005 One of the most successful chromatic adaptations in vertebrates is the dorsal-ventral pigment pattern in which the dorsal skin is darkly colored, whereas the ventrum is light.
Schioth, H.B. +3 more
core +1 more source
Melanocortin receptor accessory proteins in adrenal disease and obesity [PDF]
, 2015 This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the ...
Shwetha Ramachandrappa +11 more
core +1 more source
Frontiers in Endocrinology, 2019 The melanocortin-4 receptor (MC4R) can be endogenously activated by binding of melanocyte-stimulating hormones (MSH), which mediates anorexigenic effects. In contrast, the agouti-related peptide (AgRP) acts as an endogenous inverse agonist and suppresses
Nicolas Heyder +10 more
doaj +1 more source
The Alpha-Melanocyte-Stimulating Hormone Suppresses TLR2-Mediated Functional Responses through IRAK-M in Normal Human Keratinocytes. [PDF]
PLoS ONE, 2015 Alpha-melanocyte stimulating hormone (α-MSH) is a highly conserved 13-aa neuropeptide derived from pro-opiomelanocortin by post-translational processing, which has been reported to exhibit potent anti-inflammatory activity and a wide range of ...
Sunhyo Ryu +6 more
doaj +1 more source
Biomedicines, 2023 Neuronal circuits regulating appetite are dominated by arcuate nucleus neurons, which include appetite-promoting and -suppressing neurons that release the orexigenic neuropeptide agouti-related protein (AgRP) and anorexigenic neuropeptide pro ...
Chiu-Ya Lin +3 more
doaj +1 more source
Effects of hypothalamic neurodegeneration on energy balance. [PDF]
PLoS Biology, 2005 Normal aging in humans and rodents is accompanied by a progressive increase in adiposity. To investigate the role of hypothalamic neuronal circuits in this process, we used a Cre-lox strategy to create mice with specific and progressive degeneration of ...
Allison Wanting Xu +9 more
doaj +2 more sources
Frontiers in Endocrinology, 2022 The melanocortin system consists of five G protein–coupled receptors (MC1R-MC5R), the bidirectional endogenous ligands (MSH and Agouti families), and accessory proteins (MRAP1 and MRAP2).
Xiaolu Tai +8 more
doaj +1 more source
Food Safety and Health, EarlyView.Circadian rhythm disruption impairs metabolic regulation, appetite control, and vascular function, promoting obesity and cardiovascular diseases. Evidence highlights a bidirectional relationship where metabolic disorders further disturb circadian timing.
Ghizal Fatima +4 more
wiley +1 more source
The melanocortin 1 receptor is the principal mediator of the effects of agouti signaling protein on mammalian melanocytes [PDF]
Journal of Cell Science, 2001 ABSTRACT The agouti gene codes for agouti signaling protein (ASP), which is temporally expressed in wild-type mouse follicular melanocytes where it induces pheomelanin synthesis. Studies using purified full-length agouti signaling protein has shown that it competes with α-melanocyte stimulating hormone for binding to the melanocortin 1 ...
Z A, Abdel-Malek +6 more
openaire +2 more sources