Results 51 to 60 of about 17,109 (214)

Identification of a GABAergic neural circuit governing leptin signaling deficiency-induced obesity

eLife, 2023
The hormone leptin is known to robustly suppress food intake by acting upon the leptin receptor (LepR) signaling system residing within the agouti-related protein (AgRP) neurons of the hypothalamus.
Yong Han, Yang He, Lauren Harris, Yong Xu, Qi Wu   +4 more
doaj   +1 more source

Pathophysiology of melanocortin receptors and their accessory proteins. [PDF]

, 2018
The melanocortin receptors (MCRs) and their accessory proteins (MRAPs) are involved in regulation of a diverse range of endocrine pathways. Genetic variants of these components result in phenotypic variation and disease. The MC1R is expressed in skin and
A.J.L. Clark, Anderson, Asai, Balthasar, Begriche, Benjannet, Bishop, Box, Buggy, Bultman, Butler, Butler, Böhm, Chakraborty, Chaly, Chan, Chan, Chan, Chen, Chen, Chen, Cheung, Chida, Chung, Chung, Clark, Clark, Clark, Clark, Coll, Collet, Cone, Cone, Cooray, Cooray, Cooray, Cui, D'Orazio, do Carmo, Elias, Enriori, Farooqi, Feng, Flier, Friedman, Gee, Ghamari-Langroudi, Girardet, Gonzalez-Rey, Gorrigan, Greenfield, Huszar, Jarrett, Kievit, Kim, L.F. Chan, Landi, Lee, Lee, Lembertas, Lim, Lovett, Lowry, Lu, Manceau, Markison, Marks, Marsh, Martinelli, Metherell, Metherell, Miller, Mirshahi, Morgan, Morgan, Morgan, Mountjoy, Mountjoy, Ni, Nimura, Novoselova, O'Rahilly, Ogawa, Ollmann, Padilla, Palmer, Pasquali, Pelleymounter, Raadsheer, Rached, Raimondi, Robbins, Robles-Espinoza, Rodrigues, Roselli-Rehfuss, Rouault, Roy, Schauer, Scott, Sebag, Sebag, Shen, Shenker, Simamura, Smith, Smith, Sohn, Srisai, Swords, T.V. Novoselova, Tao, Turan, Ulrich-Lai, Vaisse, Valverde, Vinson, Webb, Webb, Weber, Williams, Xu, Xu, Yang, Yeo, Young, Zhang, Zhang   +126 more
core   +2 more sources

The Emerging Role of Ten-Eleven Translocation 1 in Epigenetic Responses to Environmental Exposures. [PDF]

, 2020
Mounting evidence from epidemiological studies and animal models has linked exposures to environmental factors to changes in epigenetic markers, especially in DNA methylation.
Brown, Anthony P, Ji, Hong, Zhu, Tao
core  

Physiopathological Implications of 7TM Receptors [PDF]

, 2010
Seven-transmembrane (7TM) receptors are one of the most important proteins involved in perception of extracellular stimuli and regulation of variety of intracellular signaling pathways.
Cygankiewicz, Adam
core   +2 more sources

The Alpha-Melanocyte-Stimulating Hormone Suppresses TLR2-Mediated Functional Responses through IRAK-M in Normal Human Keratinocytes. [PDF]

PLoS ONE, 2015
Alpha-melanocyte stimulating hormone (α-MSH) is a highly conserved 13-aa neuropeptide derived from pro-opiomelanocortin by post-translational processing, which has been reported to exhibit potent anti-inflammatory activity and a wide range of ...
Sunhyo Ryu, Andrew Johnson, Yoonkyung Park, Beomjoon Kim, David Norris, Cheryl A Armstrong, Peter I Song   +6 more
doaj   +1 more source

AgRP Neuron-Specific Ablation Represses Appetite, Energy Intake, and Somatic Growth in Larval Zebrafish

Biomedicines, 2023
Neuronal circuits regulating appetite are dominated by arcuate nucleus neurons, which include appetite-promoting and -suppressing neurons that release the orexigenic neuropeptide agouti-related protein (AgRP) and anorexigenic neuropeptide pro ...
Chiu-Ya Lin, Kun-Yun Yeh, Hsin-Hung Lai, Guor Mour Her   +3 more
doaj   +1 more source

Activity Based Anorexia as an Animal Model for Anorexia Nervosa–A Systematic Review [PDF]

, 2019
Anorexia nervosa (AN) is a severe eating disorder affecting around 1 per 100 persons. However, the knowledge about its underlying pathophysiology is limited.
Schalla, Martha A., Stengel, Andreas
core   +1 more source

Effects of hypothalamic neurodegeneration on energy balance. [PDF]

PLoS Biology, 2005
Normal aging in humans and rodents is accompanied by a progressive increase in adiposity. To investigate the role of hypothalamic neuronal circuits in this process, we used a Cre-lox strategy to create mice with specific and progressive degeneration of ...
Allison Wanting Xu, Christopher B Kaelin, Gregory J Morton, Kayoko Ogimoto, Kimber Stanhope, James Graham, Denis G Baskin, Peter Havel, Michael W Schwartz, Gregory S Barsh   +9 more
doaj   +2 more sources

Pharmacological Modulation of Melanocortin 1 Receptor Signaling by Mrap Proteins in Xenopus tropicalis

Frontiers in Endocrinology, 2022
The melanocortin system consists of five G protein–coupled receptors (MC1R-MC5R), the bidirectional endogenous ligands (MSH and Agouti families), and accessory proteins (MRAP1 and MRAP2).
Xiaolu Tai, Yaqun Zhang, Jindong Yao, Xuan Li, Jun Liu, Jiazhen Han, Jianjun Lyu, Gufa Lin, Chao Zhang   +8 more
doaj   +1 more source

Monogenic and syndromic obesity in children: Clinical recognition, genetics, and precision management

Pediatric Investigation, EarlyView.
Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil, Eugene Feigin, Hussein Zaitoon   +2 more
wiley   +1 more source