Results 1 to 10 of about 20,021 (258)
Food cue regulation of AGRP hunger neurons guides learning [PDF]
Nature, 2021 Agouti-related peptide (AGRP)-expressing neurons are activated by fasting-this causes hunger1-4, an aversive state that motivates the seeking and consumption of food5,6. Eating returns AGRP neuron activity towards baseline on three distinct timescales: rapidly and transiently following sensory detection of food cues6-8, slowly and longer-lasting in ...
Janet Berrios +6 more
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CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst [PDF]
Biology of Sex Differences, 2023 Highlights Fatty acid metabolism and CPT1A in AgRP neurons show marked sex-dependent differences in the control of feeding. Cpt1a gene deletion in AgRP neurons increases energy expenditure in females but not in males. CPT1A in AgRP neurons is involved in
Sebastián Zagmutt +23 more
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Nutritive, Post-ingestive Signals Are the Primary Regulators of AgRP Neuron Activity [PDF]
Cell Reports, 2017 Summary: The brain regulates food intake by processing sensory cues and peripheral physiological signals, but the neural basis of this integration remains unclear.
Zhenwei Su +2 more
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PGC-1α expression in murine AgRP neurons regulates food intake and energy balance [PDF]
Molecular Metabolism, 2016 Objective: Food intake and whole-body energy homeostasis are controlled by agouti-related protein (AgRP) and pro-opiomelanocortin (POMC) neurons located in the arcuate nucleus of the hypothalamus.
Jonathan F. Gill +3 more
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UCP2 mediates mitochondrial dynamics to induce AgRP neuronal activity [PDF]
Molecular MetabolismObjectives: The hypothalamic agouti-related protein (AgRP)- expressing neurons regulate feeding and whole-body energy homeostasis. A growing body of evidence indicates that changes in mitochondrial dynamics, such as fission and fusion, play a crucial ...
Sungho Jin +6 more
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Dax1 in AgRP neurons regulates thermogenesis via GR-HDAC3-mediated CRFR1 suppression [PDF]
Molecular MetabolismObjectives: The arcuate nucleus of the hypothalamus plays a pivotal role in metabolic homeostasis by integrating the functions of AgRP and POMC neurons. Dax1, a nuclear receptor-like transcription factor, is highly enriched in AgRP neurons; however, its ...
Zhuodu Wei, Jooseon Cha, Seunghee Lee
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Molecular MetabolismObjective: The control of energy balance involves neural circuits in the central nervous system, including AGRP neurons in the arcuate nucleus of the hypothalamus (ARC).
Valerie Espinal Abreu +4 more
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Loss of GABAergic Signaling by AgRP Neurons to the Parabrachial Nucleus Leads to Starvation [PDF]
Cell, 2009 Qi Wu +2 more
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eLifeAgouti-related peptide (AgRP) neurons in the arcuate nucleus of the hypothalamus respond to multiple metabolic signals and distribute neuroendocrine information to other brain regions such as the paraventricular hypothalamic nucleus (PVH), which plays a ...
Haley N Mendoza-Romero +3 more
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FTO promotes weight gain via altering Kif1a splicing and axonal vesicle trafficking in AgRP neurons [PDF]
The EMBO JournalN6-methyladenosine (m6A) is an abundant chemical RNA modification involved in the regulation of many biological processes. The m6A demethylase FTO (fat mass and obesity-associated protein) is known to affect body weight, but its systemic context and ...
Daisuke Kohno +21 more
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