Results 11 to 20 of about 9,029 (175)
Ablation of AgRP neurons impairs adaption to restricted feeding
Molecular Metabolism, 2014 While the SCN controls the circadian clock, further evidence suggests the existence of a food-entrainable oscillator (FEO) that links behavior to changes in food availability such as during restricted feeding (RF). We found that the activity of AgRP/NPY neurons changed rhythmically during RF suggesting that these neurons are a component of the FEO.
Zachary Knight, Jeffrey M Friedman
exaly +5 more sources
Biomedicines, 2023 Neuronal circuits regulating appetite are dominated by arcuate nucleus neurons, which include appetite-promoting and -suppressing neurons that release the orexigenic neuropeptide agouti-related protein (AgRP) and anorexigenic neuropeptide pro ...
Chiu-Ya Lin +3 more
doaj +1 more source
Frontiers in Physiology, 2020 The orexigenic agouti-related protein (AgRP) and the anorexigenic pro-opiomelanocortin (POMC) are crucial players in the control of feed intake in vertebrates, yet their role in teleosts has not been fully established.
Tharmini Kalananthan +15 more
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Molecular Metabolism, 2023 Objective: The learned associations between sensory cues (e.g., taste, smell) and nutritive value (e.g., calories, post-ingestive signaling) of foods powerfully influences our eating behavior [1], but the neural circuits that mediate these associations ...
Nathaniel T. Nyema +6 more
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Acute inhibition of hunger-sensing AgRP neurons promotes context-specific learning in mice
Molecular Metabolism, 2023 Objective: An environmental context, which reliably predicts food availability, can increase the appetitive food drive within the same environment context.
Felicia Reed +9 more
doaj +1 more source
AgRP Accountants Compute Caloric Cost [PDF]
Cell Reports, 2017 The gut-brain communication underlying energy homeostasis has been a topic of interest for years. In two new papers, Beutler et al. (2017) and Su et al. (2017) delve into the mechanisms by which satiation is represented in a well-studied population of orexigenic neurons.
Jing Liang, Michael J. Krashes
openaire +3 more sources
eLife, 2022 Agouti-related peptide (AgRP) neurons increase motivation for food, however, whether metabolic sensing of homeostatic state in AgRP neurons potentiates motivation by interacting with dopamine reward systems is unexplored. As a model of impaired metabolic-
Alex Reichenbach +17 more
doaj +1 more source
GIRK2 potassium channels expressed by the AgRP neurons decrease adiposity and body weight in mice.
PLoS Biology, 2023 It is well known that the neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons increase appetite and decrease thermogenesis. Previous studies demonstrated that optogenetic and/or chemogenetic manipulations of NPY/AgRP neuronal activity alter food ...
Youjin Oh +7 more
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AgRP neurons are not indispensable for body weight maintenance in adult mice
Cell Reports, 2023 Summary: In addition to their role in promoting feeding and obesity development, hypothalamic arcuate agouti-related protein/neuropeptide Y (AgRP/NPY) neurons are widely perceived to be indispensable for maintaining normal feeding and body weight in ...
Jing Cai +9 more
doaj +1 more source
The gut signals to AGRP-expressing cells of the pituitary to control glucose homeostasis
The Journal of Clinical Investigation, 2023 Glucose homeostasis can be improved after bariatric surgery, which alters bile flow and stimulates gut hormone secretion, particularly FGF15/19. FGFR1 expression in AGRP-expressing cells is required for bile acids’ ability to improve glucose control.
Shun-Mei Liu +8 more
doaj +1 more source