Results 11 to 20 of about 8,978 (173)
AgRP Neurons Regulate Bone Mass [PDF]
Cell Reports, 2015 The hypothalamus has been implicated in skeletal metabolism. Whether hunger-promoting neurons of the arcuate nucleus impact the bone is not known. We generated multiple lines of mice to affect AgRP neuronal circuit integrity. We found that mice with Ucp2
Jae Geun Kim +7 more
doaj +6 more sources
Reanalysis of Evidence for/against AGRP in Korean [PDF]
Kansas Working Papers in Linguistics, 1998 This article deals with the controversial issue of AgrP in Korean within the Minimalist Program. Some linguists maintain that there is AgrP in Korean, while others not. In this article I review the evidence for and against the existence of AgrP in Korean,
Khym, Hangyoo
doaj +2 more sources
Mammalian comparative sequence analysis of the Agrp locus. [PDF]
PLoS ONE, 2007 Agouti-related protein encodes a neuropeptide that stimulates food intake. Agrp expression in the brain is restricted to neurons in the arcuate nucleus of the hypothalamus and is elevated by states of negative energy balance.
Christopher B Kaelin +3 more
doaj +4 more sources
Altered responses to ghrelin and food cues in AgRP neurons during pregnancy and lactation. [PDF]
J NeuroendocrinolAbstract Pregnancy and lactation trigger many metabolic adaptations, including increased food intake to support the energy demands of the growing foetus and then to provide nutrition through milk production after birth. Ghrelin, an orexigenic hormone, activates agouti related peptide (AgRP) neurons in the arcuate nucleus to promote food intake.
Murrell CL +4 more
europepmc +2 more sources
Hydroxy-α-Sanshools From <i>Zanthoxylum bungeanum</i> Maxim. Alleviate Obesity in Mice via the Regulation of Appetite and Gut Microbiota. [PDF]
Food Sci NutrHydroxy‐alpha‐sanshool could modulate the expression of appetite‐related factors and the composition of intestinal microbiota in mice fed with a high‐fat diet by regulating food intake and maintaining energy homeostasis, which is consistent with the involvement of the gut‐brain axis in this regulatory mechanism.
Luo T +6 more
europepmc +2 more sources
SemaGBA: A System Dynamics Model of the Semaglutide-Responsive Gut-Brain Axis A Model of How the Brain and Semaglutide Regulate Appetite and Weight. [PDF]
Diabetes Obes MetabABSTRACT Aims Semaglutide is a GLP‐1 receptor agonist for the treatment of type 2 diabetes and obesity. Its clinical effects are well established, but the underlying mechanisms remain unclear. This study aims to use computational modelling to generate hypotheses about semaglutide's long‐term metabolic (body weight, net energy intake, blood glucose ...
Kennis VCW, van Riel NAW.
europepmc +2 more sources
G Protein-Coupled Receptor 17 (Gpr17) Enhances Leptin and Insulin Sensitivity in Lean and Obese Mouse Models. [PDF]
Obesity (Silver Spring)This study identifies G protein‐coupled receptor 17 (Gpr17) as a novel regulator of leptin and insulin sensitivity. Using complementary knockout models, we demonstrate that Gpr17 deletion enhances energy expenditure, restores leptin responsiveness, and improves insulin sensitivity, revealing Gpr17 as a potential therapeutic GPCR target for obesity and ...
Sun X +8 more
europepmc +2 more sources
Acute inhibition of hunger-sensing AgRP neurons promotes context-specific learning in mice
Molecular Metabolism, 2023 Objective: An environmental context, which reliably predicts food availability, can increase the appetitive food drive within the same environment context.
Felicia Reed +9 more
doaj +1 more source
AgRP Accountants Compute Caloric Cost [PDF]
Cell Reports, 2017 The gut-brain communication underlying energy homeostasis has been a topic of interest for years. In two new papers, Beutler et al. (2017) and Su et al. (2017) delve into the mechanisms by which satiation is represented in a well-studied population of orexigenic neurons.
Jing Liang, Michael J. Krashes
openaire +3 more sources
eLife, 2022 Agouti-related peptide (AgRP) neurons increase motivation for food, however, whether metabolic sensing of homeostatic state in AgRP neurons potentiates motivation by interacting with dopamine reward systems is unexplored. As a model of impaired metabolic-
Alex Reichenbach +17 more
doaj +1 more source