Results 11 to 20 of about 20,021 (258)
Molecular Metabolism, 2023 Objective: The sensory detection of food and food cues suppresses Agouti related peptide (AgRP) neuronal activity prior to consumption with greatest suppression occurring in response to highly caloric food or interoceptive energy need.
Wang Lok So +8 more
doaj +3 more sources
AgRP Neurons Regulate Bone Mass [PDF]
Cell Reports, 2015 The hypothalamus has been implicated in skeletal metabolism. Whether hunger-promoting neurons of the arcuate nucleus impact the bone is not known. We generated multiple lines of mice to affect AgRP neuronal circuit integrity. We found that mice with Ucp2
Jae Geun Kim +7 more
doaj +6 more sources
Drp1 is required for AgRP neuronal activity and feeding
eLife, 2021 The hypothalamic orexigenic Agouti-related peptide (AgRP)-expressing neurons are crucial for the regulation of whole-body energy homeostasis. Here, we show that fasting-induced AgRP neuronal activation is associated with dynamin-related peptide 1 (DRP1 ...
Sungho Jin +6 more
doaj +3 more sources
Sustained NPY signaling enables AgRP neurons to drive feeding
eLife, 2019 Artificial stimulation of Agouti-Related Peptide (AgRP) neurons promotes intense food consumption, yet paradoxically during natural behavior these cells are inhibited before feeding begins.
Yiming Chen +6 more
doaj +3 more sources
Mammalian comparative sequence analysis of the Agrp locus. [PDF]
PLoS ONE, 2007 Agouti-related protein encodes a neuropeptide that stimulates food intake. Agrp expression in the brain is restricted to neurons in the arcuate nucleus of the hypothalamus and is elevated by states of negative energy balance.
Christopher B Kaelin +3 more
doaj +4 more sources
Hypothalamic Agrp Neurons Drive Stereotypic Behaviors beyond Feeding [PDF]
Cell, 2017 The nervous system evolved to coordinate flexible goal-directed behaviors by integrating interoceptive and sensory information. Hypothalamic Agrp neurons are known to be crucial for feeding behavior. Here, however, we show that these neurons also orchestrate other complex behaviors in adult mice.
Marcelo O. Dietrich +3 more
openalex +6 more sources
AgRP neuronal activity across feeding‐related behaviours [PDF]
European Journal of Neuroscience, 2021 Abstract AgRP neurons trigger one of the most potent orexigenic responses and are both necessary and sufficient for feeding. Recent technical advances for monitoring in vivo neuronal activity have revisited a previously well‐established model of AgRP neurons' feeding regulatory effects.
Gouveia, Ayden +2 more
openaire +3 more sources
A central role for C1q/TNF-related protein 13 (CTRP13) in modulating food intake and body weight. [PDF]
, 2013 C1q/TNF-related protein 13 (CTRP13), a hormone secreted by adipose tissue (adipokines), helps regulate glucose metabolism in peripheral tissues. We previously reported that CTRP13 expression is increased in obese and hyperphagic leptin-deficient mice ...
Byerly, Mardi S +5 more
core +12 more sources
Insulin Action in AgRP-Expressing Neurons Is Required for Suppression of Hepatic Glucose Production [PDF]
Cell Metabolism, 2007 A. Christine Könner +13 more
openalex +3 more sources