Results 31 to 40 of about 9,029 (175)
Temporal Control of Appetite by AgRP Clocks [PDF]
Cell Metabolism, 2019 Neuronal control of diurnal appetitive drive is not well understood. In this issue, a study by Cedernaes et al. (2019) elucidates a key role of AgRP neuronal clocks and delineates the cell-type-specific transcriptional landscape in the temporal regulation of hunger.
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PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure. [PDF]
PLoS ONE, 2011 Insulin and leptin intracellular signaling pathways converge and act synergistically on the hypothalamic phosphatidylinositol-3-OH kinase/3-phosphoinositide-dependent protein kinase 1 (PDK1).
Yongheng Cao +17 more
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eLife, 2015 Agouti-related-peptide (AgRP) neurons—interoceptive neurons in the arcuate nucleus of the hypothalamus (ARC)—are both necessary and sufficient for driving feeding behavior. To better understand the functional roles of AgRP neurons, we performed optetrode
Yael Mandelblat-Cerf +6 more
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AgRP-deficiency could lead to increased lifespan [PDF]
Biochemical and Biophysical Research Communications, 2006 The Agouti-related protein (AgRP) is a central orexigenic peptide leading to increased food intake when ubiquitously overexpressed. AgRP-deficient (AgRP(-/-)) mice have either no phenotype or present an age-related leanness. In this study, AgRP(-/-) mice were fed alternate high fat or low fat diets in an effort to determine whether AgRP is a mediating ...
Stephen M, Redmann, George, Argyropoulos
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Hypoxia inducible factor-dependent upregulation of Agrp in glomus type I cells of the carotid body
Molecular MetabolismAgouti-related peptide (AgRP) is a well-established potent orexigenic peptide primarily expressed in hypothalamic neurons. Nevertheless, the expression and functional significance of extrahypothalamic AgRP remain poorly understood.
Luis Leon-Mercado +7 more
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Вавиловский журнал генетики и селекции, 2016 Hypothalamic melanortin receptor (MCR) activation inhibits appetite. Neuropeptide Y (NPY) and Agouti Related Protein (AgRP) are coexpressed in some hypothalamic neurons and stimulate feeding, NPY via inhibition of MCR-expressing neurons, and AgRP via ...
E. N. Makarova +2 more
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Regulation of substrate utilization and adiposity by Agrp neurons [PDF]
Nature Communications, 2019 Abstract The type of nutrient utilized by the organism at any given time—substrate utilization—is a critical component of energy metabolism. The neuronal mechanisms involved in the regulation of substrate utilization in mammals are largely unknown.
João Paulo Cavalcanti-de-Albuquerque +3 more
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Effects of Thymoquinone on Hypothalamic NPY and AgRP Gene Expression in Intact and Hypothyroidism- Model Rats [PDF]
Journal of Advanced Biomedical Sciences, 2022 Background & Objective: Thymoquinone is the most important compound of Nigella sativa, which stimulates the activity of thyroid axis in healthy individuals and people with hypothyroidism.
Nasrin Ghahremani, Fariba Mahmoudi
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Animal Models and Experimental Medicine, EarlyView.Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
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Animal Cells and Systems, 2019 Fatty acids regulate food intake, although the exact mechanism remains unknown. Emerging evidence suggests that intracellular free fatty acids generated by starvation-induced autophagy regulate food intake. Starvation for 6 h elevated fatty acids such as
Seokjae Park +3 more
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