Results 31 to 40 of about 8,978 (173)

Rapid versus Delayed Stimulation of Feeding by the Endogenously Released AgRP Neuron Mediators GABA, NPY, and AgRP [PDF]

Cell Metabolism, 2013
Agouti-related peptide (AgRP) neurons of the hypothalamus release a fast transmitter (GABA) in addition to neuropeptides (neuropeptide Y [NPY] and Agouti-related peptide [AgRP]). This raises questions as to their respective functions. The acute activation of AgRP neurons robustly promotes food intake, while central injections of AgRP, NPY, or GABA ...
Krashes, Michael J., Shah, Bhavik P., Koda, Shuichi, Lowell, Bradford B.   +3 more
openaire   +2 more sources

Arcuate AgRP neurons and the regulation of energy balance [PDF]

Frontiers in Endocrinology, 2012
The arcuate nucleus of the hypothalamus contains at least two populations of neurons that continuously monitor signals reflecting energy status and promote the appropriate behavioral and metabolic responses to changes in energy demand. Activation of neurons making pro-opiomelanocortin (POMC) decreases food intake and increases energy expenditure ...
Céline eCansell, Raphaël G.P Denis, Aurélie eJoly-Amado, Julien eCastel, Julien eCastel, Serge H Luquet, Serge H Luquet   +6 more
openaire   +4 more sources

PDK1-FoxO1 pathway in AgRP neurons of arcuate nucleus promotes bone formation via GHRH-GH-IGF1 axis

Molecular Metabolism, 2017
Objective: In the hypothalamic arcuate nucleus (ARC), orexigenic agouti-related peptide (AgRP) neurons regulate feeding behavior and energy homeostasis, functions connected to bone metabolism.
Hideyuki Sasanuma, Masanori Nakata, Kumari Parmila, Jun Nakae, Toshihiko Yada   +4 more
doaj   +1 more source

PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure. [PDF]

PLoS ONE, 2011
Insulin and leptin intracellular signaling pathways converge and act synergistically on the hypothalamic phosphatidylinositol-3-OH kinase/3-phosphoinositide-dependent protein kinase 1 (PDK1).
Yongheng Cao, Masanori Nakata, Shiki Okamoto, Eisuke Takano, Toshihiko Yada, Yasuhiko Minokoshi, Yukio Hirata, Kazunori Nakajima, Kristy Iskandar, Yoshitake Hayashi, Wataru Ogawa, Gregory S Barsh, Hiroshi Hosoda, Kenji Kangawa, Hiroshi Itoh, Tetsuo Noda, Masato Kasuga, Jun Nakae   +17 more
doaj   +1 more source

Temporal Control of Appetite by AgRP Clocks [PDF]

Cell Metabolism, 2019
Neuronal control of diurnal appetitive drive is not well understood. In this issue, a study by Cedernaes et al. (2019) elucidates a key role of AgRP neuronal clocks and delineates the cell-type-specific transcriptional landscape in the temporal regulation of hunger.
openaire   +2 more sources

Arcuate hypothalamic AgRP and putative POMC neurons show opposite changes in spiking across multiple timescales

eLife, 2015
Agouti-related-peptide (AgRP) neurons—interoceptive neurons in the arcuate nucleus of the hypothalamus (ARC)—are both necessary and sufficient for driving feeding behavior. To better understand the functional roles of AgRP neurons, we performed optetrode
Yael Mandelblat-Cerf, Rohan N Ramesh, Christian R Burgess, Paola Patella, Zongfang Yang, Bradford B Lowell, Mark L Andermann   +6 more
doaj   +1 more source

AgRP-deficiency could lead to increased lifespan [PDF]

Biochemical and Biophysical Research Communications, 2006
The Agouti-related protein (AgRP) is a central orexigenic peptide leading to increased food intake when ubiquitously overexpressed. AgRP-deficient (AgRP(-/-)) mice have either no phenotype or present an age-related leanness. In this study, AgRP(-/-) mice were fed alternate high fat or low fat diets in an effort to determine whether AgRP is a mediating ...
Stephen M, Redmann, George, Argyropoulos
openaire   +2 more sources

Hypoxia inducible factor-dependent upregulation of Agrp in glomus type I cells of the carotid body

Molecular Metabolism
Agouti-related peptide (AgRP) is a well-established potent orexigenic peptide primarily expressed in hypothalamic neurons. Nevertheless, the expression and functional significance of extrahypothalamic AgRP remain poorly understood.
Luis Leon-Mercado, Ivan Menendez-Montes, Jonathan Tao, Bandy Chen, David P. Olson, C. Mackaaij, C.G.J. Cleypool, Laurent Gautron   +7 more
doaj   +1 more source

Effects of Thymoquinone on Hypothalamic NPY and AgRP Gene Expression in Intact and Hypothyroidism- Model Rats [PDF]

Journal of Advanced Biomedical Sciences, 2022
Background & Objective: Thymoquinone is the most important compound of Nigella sativa, which stimulates the activity of thyroid axis in healthy individuals and people with hypothyroidism.
Nasrin Ghahremani, Fariba Mahmoudi
doaj  

Sustained NPY signaling enables AgRP neurons to drive feeding

eLife, 2019
Artificial stimulation of Agouti-Related Peptide (AgRP) neurons promotes intense food consumption, yet paradoxically during natural behavior these cells are inhibited before feeding begins.
Yiming Chen, Rachel A Essner, Seher Kosar, Oliver H Miller, Yen-Chu Lin, Sheyda Mesgarzadeh, Zachary A Knight   +6 more
doaj   +1 more source