Results 31 to 40 of about 20,021 (258)
The gut signals to AGRP-expressing cells of the pituitary to control glucose homeostasis
The Journal of Clinical Investigation, 2023 Glucose homeostasis can be improved after bariatric surgery, which alters bile flow and stimulates gut hormone secretion, particularly FGF15/19. FGFR1 expression in AGRP-expressing cells is required for bile acids’ ability to improve glucose control.
Shun-Mei Liu +8 more
doaj +1 more source
Effects of AgRP inhibition on energy balance and metabolism in rodent models. [PDF]
PLoS ONE, 2013 Activation of brain melanocortin-4 receptors (MC4-R) by α-melanocyte-stimulating hormone (MSH) or inhibition by agouti-related protein (AgRP) regulates food intake and energy expenditure and can modulate neuroendocrine responses to changes in energy ...
Roxanne Dutia +9 more
doaj +1 more source
Hypothalamic gene expression during voluntary hypophagia in the Sprague-Dawley rat on withdrawal of the palatable liquid diet, Ensure [PDF]
, 2014 Copyright © 2014 Elsevier Inc.
Archer, Zoe A +2 more
core +1 more source
Dynamic GABAergic afferent modulation of AgRP neurons [PDF]
Nature Neuroscience, 2016 Agouti-related peptide (AgRP) neurons of the arcuate nucleus of the hypothalamus (ARC) promote homeostatic feeding at times of caloric insufficiency, yet they are rapidly suppressed by food-related sensory cues before ingestion. Here we identify a highly selective inhibitory afferent to AgRP neurons that serves as a neural determinant of this rapid ...
Garfield, Alastair S +14 more
openaire +4 more sources
AgRP-deficiency could lead to increased lifespan [PDF]
Biochemical and Biophysical Research Communications, 2006 The Agouti-related protein (AgRP) is a central orexigenic peptide leading to increased food intake when ubiquitously overexpressed. AgRP-deficient (AgRP(-/-)) mice have either no phenotype or present an age-related leanness. In this study, AgRP(-/-) mice were fed alternate high fat or low fat diets in an effort to determine whether AgRP is a mediating ...
Stephen M, Redmann, George, Argyropoulos
openaire +2 more sources
Cells, 2023 Hypothalamic mTORC1 signaling is involved in nutrient sensing. Neurons that express the agouti-related protein (AgRP) are activated by food restriction and integrate interoceptive and exteroceptive signals to control food intake, energy expenditure, and ...
Gabriel O. de Souza +3 more
doaj +1 more source
Reanalysis of Evidence for/against AGRP in Korean
Kansas Working Papers in Linguistics, 1998 This article deals with the controversial issue of AgrP in Korean within the Minimalist Program. Some linguists maintain that there is AgrP in Korean, while others not. In this article I review the evidence for and against the existence of AgrP in Korean,
Khym, Hangyoo
doaj +1 more source
Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice [PDF]
, 2018 We thank AstraZeneca for providing AZ-4217, Mark Smith (Imperial College, London) and Yuchio Yanagawa (Gunma University, Maebashi) for VGlut2-GFP and GAD67-GFP tissue, respectively.
Allsop, David J. P. +15 more
core +5 more sources
AgRP in energy balance: Will the real AgRP please stand up? [PDF]
Cell Metabolism, 2006 The neuropeptide AgRP promotes food intake and weight gain by antagonizing signaling at melanocortin 3 and 4 receptors in the brain, but the limited phenotype of mice lacking AgRP raised questions about its importance. Four recent studies addressed this by creating mice in which AgRP neurons, which also express NPY and GABA, are ablated postnatally ...
openaire +2 more sources
PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure. [PDF]
PLoS ONE, 2011 Insulin and leptin intracellular signaling pathways converge and act synergistically on the hypothalamic phosphatidylinositol-3-OH kinase/3-phosphoinositide-dependent protein kinase 1 (PDK1).
Yongheng Cao +17 more
doaj +1 more source