Results 21 to 30 of about 9,029 (175)
Motivation to Eat—AgRP Neurons and Homeostatic Need [PDF]
Cell Metabolism, 2015 Activation of AgRP neurons potently induces feeding behaviors; however, whether this activity is involved in motivations of feeding behavior is unclear. A recent study in Nature (Betley et al., 2015) reports that AgRP neuron activity conditions learned behavior by transmitting a negative-valence signal: linking AgRP neurons to the preference of ...
Yang, Dengbao +2 more
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AgRP in energy balance: Will the real AgRP please stand up? [PDF]
Cell Metabolism, 2006 The neuropeptide AgRP promotes food intake and weight gain by antagonizing signaling at melanocortin 3 and 4 receptors in the brain, but the limited phenotype of mice lacking AgRP raised questions about its importance. Four recent studies addressed this by creating mice in which AgRP neurons, which also express NPY and GABA, are ablated postnatally ...
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Dynamic GABAergic afferent modulation of AgRP neurons [PDF]
Nature Neuroscience, 2016 Agouti-related peptide (AgRP) neurons of the arcuate nucleus of the hypothalamus (ARC) promote homeostatic feeding at times of caloric insufficiency, yet they are rapidly suppressed by food-related sensory cues before ingestion. Here we identify a highly selective inhibitory afferent to AgRP neurons that serves as a neural determinant of this rapid ...
Garfield, Alastair S +14 more
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Effects of AgRP inhibition on energy balance and metabolism in rodent models. [PDF]
PLoS ONE, 2013 Activation of brain melanocortin-4 receptors (MC4-R) by α-melanocyte-stimulating hormone (MSH) or inhibition by agouti-related protein (AgRP) regulates food intake and energy expenditure and can modulate neuroendocrine responses to changes in energy ...
Roxanne Dutia +9 more
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Cells, 2023 Hypothalamic mTORC1 signaling is involved in nutrient sensing. Neurons that express the agouti-related protein (AgRP) are activated by food restriction and integrate interoceptive and exteroceptive signals to control food intake, energy expenditure, and ...
Gabriel O. de Souza +3 more
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Science-Business eXchange, 2012 New York researchers have identified GPR17 as a potentially druggable target on AGRP neurons, which are known to regulate factors relevant to obesity. The findings open up a new pathway to mine for therapeutic strategies against a cell population for which earlier targeting strategies have had little success.
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Rapid versus Delayed Stimulation of Feeding by the Endogenously Released AgRP Neuron Mediators GABA, NPY, and AgRP [PDF]
Cell Metabolism, 2013 Agouti-related peptide (AgRP) neurons of the hypothalamus release a fast transmitter (GABA) in addition to neuropeptides (neuropeptide Y [NPY] and Agouti-related peptide [AgRP]). This raises questions as to their respective functions. The acute activation of AgRP neurons robustly promotes food intake, while central injections of AgRP, NPY, or GABA ...
Krashes, Michael J. +3 more
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CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst
Biology of Sex Differences, 2023 Highlights Fatty acid metabolism and CPT1A in AgRP neurons show marked sex-dependent differences in the control of feeding. Cpt1a gene deletion in AgRP neurons increases energy expenditure in females but not in males. CPT1A in AgRP neurons is involved in
Sebastián Zagmutt +23 more
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Arcuate AgRP neurons and the regulation of energy balance [PDF]
Frontiers in Endocrinology, 2012 The arcuate nucleus of the hypothalamus contains at least two populations of neurons that continuously monitor signals reflecting energy status and promote the appropriate behavioral and metabolic responses to changes in energy demand. Activation of neurons making pro-opiomelanocortin (POMC) decreases food intake and increases energy expenditure ...
Céline eCansell +6 more
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PDK1-FoxO1 pathway in AgRP neurons of arcuate nucleus promotes bone formation via GHRH-GH-IGF1 axis
Molecular Metabolism, 2017 Objective: In the hypothalamic arcuate nucleus (ARC), orexigenic agouti-related peptide (AgRP) neurons regulate feeding behavior and energy homeostasis, functions connected to bone metabolism.
Hideyuki Sasanuma +4 more
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