Results 21 to 30 of about 8,978 (173)
GIRK2 potassium channels expressed by the AgRP neurons decrease adiposity and body weight in mice.
PLoS Biology, 2023 It is well known that the neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons increase appetite and decrease thermogenesis. Previous studies demonstrated that optogenetic and/or chemogenetic manipulations of NPY/AgRP neuronal activity alter food ...
Youjin Oh +7 more
doaj +1 more source
AgRP neurons are not indispensable for body weight maintenance in adult mice
Cell Reports, 2023 Summary: In addition to their role in promoting feeding and obesity development, hypothalamic arcuate agouti-related protein/neuropeptide Y (AgRP/NPY) neurons are widely perceived to be indispensable for maintaining normal feeding and body weight in ...
Jing Cai +9 more
doaj +1 more source
The gut signals to AGRP-expressing cells of the pituitary to control glucose homeostasis
The Journal of Clinical Investigation, 2023 Glucose homeostasis can be improved after bariatric surgery, which alters bile flow and stimulates gut hormone secretion, particularly FGF15/19. FGFR1 expression in AGRP-expressing cells is required for bile acids’ ability to improve glucose control.
Shun-Mei Liu +8 more
doaj +1 more source
Effects of AgRP inhibition on energy balance and metabolism in rodent models. [PDF]
PLoS ONE, 2013 Activation of brain melanocortin-4 receptors (MC4-R) by α-melanocyte-stimulating hormone (MSH) or inhibition by agouti-related protein (AgRP) regulates food intake and energy expenditure and can modulate neuroendocrine responses to changes in energy ...
Roxanne Dutia +9 more
doaj +1 more source
Cells, 2023 Hypothalamic mTORC1 signaling is involved in nutrient sensing. Neurons that express the agouti-related protein (AgRP) are activated by food restriction and integrate interoceptive and exteroceptive signals to control food intake, energy expenditure, and ...
Gabriel O. de Souza +3 more
doaj +1 more source
Motivation to Eat—AgRP Neurons and Homeostatic Need [PDF]
Cell Metabolism, 2015 Activation of AgRP neurons potently induces feeding behaviors; however, whether this activity is involved in motivations of feeding behavior is unclear. A recent study in Nature (Betley et al., 2015) reports that AgRP neuron activity conditions learned behavior by transmitting a negative-valence signal: linking AgRP neurons to the preference of ...
Yang, Dengbao +2 more
openaire +2 more sources
AgRP in energy balance: Will the real AgRP please stand up? [PDF]
Cell Metabolism, 2006 The neuropeptide AgRP promotes food intake and weight gain by antagonizing signaling at melanocortin 3 and 4 receptors in the brain, but the limited phenotype of mice lacking AgRP raised questions about its importance. Four recent studies addressed this by creating mice in which AgRP neurons, which also express NPY and GABA, are ablated postnatally ...
openaire +2 more sources
Dynamic GABAergic afferent modulation of AgRP neurons [PDF]
Nature Neuroscience, 2016 Agouti-related peptide (AgRP) neurons of the arcuate nucleus of the hypothalamus (ARC) promote homeostatic feeding at times of caloric insufficiency, yet they are rapidly suppressed by food-related sensory cues before ingestion. Here we identify a highly selective inhibitory afferent to AgRP neurons that serves as a neural determinant of this rapid ...
Garfield, Alastair S +14 more
openaire +5 more sources
Science-Business eXchange, 2012 New York researchers have identified GPR17 as a potentially druggable target on AGRP neurons, which are known to regulate factors relevant to obesity. The findings open up a new pathway to mine for therapeutic strategies against a cell population for which earlier targeting strategies have had little success.
openaire +1 more source
CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst
Biology of Sex Differences, 2023 Highlights Fatty acid metabolism and CPT1A in AgRP neurons show marked sex-dependent differences in the control of feeding. Cpt1a gene deletion in AgRP neurons increases energy expenditure in females but not in males. CPT1A in AgRP neurons is involved in
Sebastián Zagmutt +23 more
doaj +1 more source