Results 1 to 10 of about 7,077 (114)

Age-specific regulation of sociability by hypothalamic Agrp neurons [PDF]

Current Biology
Social isolation enhances sociability, suggesting that social behavior is maintained through a homeostatic mechanism. Further, mammalian social needs shift dramatically from infancy through adolescence into adulthood, raising the question of whether the neural mechanisms governing this homeostatic regulation evolve across developmental stages. Here, we
Marcelo R Zimmer, Gustavo M Santana, Marcelo O Dietrich   +2 more
exaly   +5 more sources

AgRP neurons: Regulators of feeding, energy expenditure, and behavior [PDF]

FEBS Journal, 2022
Neurons in the hypothalamic arcuate nucleus (ARC) that express agouti‐related peptide (AgRP) govern a critical aspect of survival: the drive to eat. Equally important to survival is the timing at which food is consumed—seeking or eating food to alleviate hunger in the face of a more pressing threat, like the risk of predation, is clearly maladaptive ...
Jennifer D Deem, Chelsea L Faber, Gregory J Morton   +2 more
exaly   +5 more sources

AgRP neurons encode circadian feeding time. [PDF]

Nat Neurosci, 2023
Food intake follows a predictable daily pattern and synchronizes metabolic rhythms. Neurons expressing agouti-related protein (AgRP) read out physiological energetic state and elicit feeding, but the regulation of these neurons across daily timescales is poorly understood.
Sayar-Atasoy N, Aklan I, Yavuz Y, Laule C, Kim H, Rysted J, Alp MI, Davis D, Yilmaz B, Atasoy D.   +9 more
europepmc   +4 more sources

Altered responses to ghrelin and food cues in AgRP neurons during pregnancy and lactation. [PDF]

J Neuroendocrinol
Abstract Pregnancy and lactation trigger many metabolic adaptations, including increased food intake to support the energy demands of the growing foetus and then to provide nutrition through milk production after birth. Ghrelin, an orexigenic hormone, activates agouti related peptide (AgRP) neurons in the arcuate nucleus to promote food intake.
Murrell CL, Perkinson MR, Andrews ZB, Grattan DR, Ladyman SR.   +4 more
europepmc   +2 more sources

Ghrelin signalling in AgRP neurons links metabolic state to the sensory regulation of AgRP neural activity. [PDF]

Mol Metab, 2023
Abstract Objective The sensory detection of food and food cues suppresses Agouti related peptide (AgRP) neuronal activity prior to consumption with greatest suppression in response to high caloric food or energy need.
So WL, Hu J, Jeffs L, Dempsey H, Lockie SH, Zigman JM, Stark R, Reichenbach A, Andrews ZB.   +8 more
europepmc   +4 more sources

Hypothalamic AgRP neurons regulate the hyperphagia of lactation. [PDF]

Mol Metab
The lactational period is associated with profound hyperphagia to accommodate the energy demands of nursing. These changes are important for the long-term metabolic health of the mother and children as altered feeding during lactation increases the risk of mothers and offspring developing metabolic disorders later in life.
Catalbas K, Pattnaik T, Congdon S, Nelson C, Villano LC, Sweeney P.   +5 more
europepmc   +3 more sources

AgRP neurons coordinate the mitigation of activity-based anorexia. [PDF]

Mol Psychiatry, 2023
Anorexia nervosa (AN) is a debilitating and deadly disease characterized by low body mass index due to diminished food intake, and oftentimes concurrent hyperactivity. A high percentage of AN behavioral and metabolic phenotypes can be replicated in rodents given access to a voluntary running wheel and subject to food restriction, termed activity-based ...
Sutton Hickey AK, Duane SC, Mickelsen LE, Karolczak EO, Shamma AM, Skillings A, Li C, Krashes MJ.   +7 more
europepmc   +3 more sources

AgRP neurons shape the sperm small RNA payload. [PDF]

Sci Rep
Abstract Paternal dietary patterns and obesity can affect offspring through epigenetic signals in sperm RNA. By activating hypothalamic Agouti-related peptide (AgRP) neurons in mice to simulate obesity’s effects, we observed changes in the small noncoding RNA payload of sperm.
Tahiri I, Llana SR, Díaz-Castro F, Claret M, Obri A.   +4 more
europepmc   +4 more sources

Heparin Increases Food Intake through AgRP Neurons [PDF]

Cell Reports, 2017
Although the widely used anticoagulant drug heparin has been shown to have many other biological functions independent of its anticoagulant role, its effects on energy homeostasis are unknown. Here, we demonstrate that heparin level is negatively associated with nutritional states and that heparin treatment increases food intake and body weight gain ...
Pingwen Xu, Yanlin He, Yexian Yuan
exaly   +4 more sources

Hypothalamic Agrp Neurons Drive Stereotypic Behaviors beyond Feeding [PDF]

Cell, 2015
The nervous system evolved to coordinate flexible goal-directed behaviors by integrating interoceptive and sensory information. Hypothalamic Agrp neurons are known to be crucial for feeding behavior. Here, however, we show that these neurons also orchestrate other complex behaviors in adult mice.
Marcelo O Dietrich, Marcelo R Zimmer, Tamás L Horvath   +2 more
exaly   +6 more sources