Dynamic GABAergic afferent modulation of AgRP neurons [PDF]
Nature Neuroscience, 2016 Agouti-related peptide (AgRP) neurons of the arcuate nucleus of the hypothalamus (ARC) promote homeostatic feeding at times of caloric insufficiency, yet they are rapidly suppressed by food-related sensory cues before ingestion. Here we identify a highly selective inhibitory afferent to AgRP neurons that serves as a neural determinant of this rapid ...
Garfield, Alastair S +14 more
openaire +5 more sources
Chemogenetic engagement of different GPCR signaling pathways segregates the orexigenic activity from the control of whole-body glucose metabolism by AGRP neurons [PDF]
Molecular MetabolismDiego Pérez-Tilve
exaly +2 more sources
Arcuate AgRP neurons and the regulation of energy balance [PDF]
Frontiers in Endocrinology, 2012 The arcuate nucleus of the hypothalamus contains at least two populations of neurons that continuously monitor signals reflecting energy status and promote the appropriate behavioral and metabolic responses to changes in energy demand. Activation of neurons making pro-opiomelanocortin (POMC) decreases food intake and increases energy expenditure ...
Céline eCansell +6 more
openaire +4 more sources
Local Drd1-neurons input to subgroups of arcuate AgRP/NPY-neurons
iScience, 2022 Obesity is a pandemic afflicting more than 300 million people worldwide, driven by consumption of calorically dense and highly rewarding foods. Dopamine (DA) signaling has been implicated in neural responses to highly palatable nutrients, but the exact mechanisms through which DA modulates homeostatic feeding circuits remains unknown.
Sean R. Chadwick, Ali D. Güler
openaire +3 more sources
Sustained inhibition of NPY/AgRP neuronal activity by FGF1 [PDF]
JCI Insight, 2022 In rodent models of type 2 diabetes (T2D), central administration of FGF1 normalizes elevated blood glucose levels in a manner that is sustained for weeks or months. Increased activity of NPY/AgRP neurons in the hypothalamic arcuate nucleus (ARC) is implicated in the pathogenesis of hyperglycemia in these animals, and the ARC is a key brain area for ...
Eunsang Hwang +13 more
openaire +4 more sources
Cpt1a silencing in AgRP neurons improves cognitive and physical capacity and promotes healthy aging in male mice [PDF]
Aging CellKevin Ibeas +2 more
exaly +2 more sources
Regulation of substrate utilization and adiposity by Agrp neurons [PDF]
Nature Communications, 2019 Abstract The type of nutrient utilized by the organism at any given time—substrate utilization—is a critical component of energy metabolism. The neuronal mechanisms involved in the regulation of substrate utilization in mammals are largely unknown.
João Paulo Cavalcanti-de-Albuquerque +3 more
openaire +3 more sources
Opioidergic signaling contributes to food-mediated suppression of AgRP neurons [PDF]
Cell ReportsConnor Laule
exaly +2 more sources
Inhibition of Itch by Hunger and AgRP Neuron Activity
Neuroscience, 2020 Unpleasant somatosensory stimuli such as pain and itch can interrupt normal behavior. But survival can depend on resuming normal behavior before these challenges are fully resolved. The neural mechanisms that prioritize behavior when individuals are challenged with unpleasant somatosensory sensations, however, are not fully understood.
Amber L, Alhadeff +3 more
openaire +3 more sources
Role of POMC and AgRP neuronal activities on glycaemia in mice [PDF]
Scientific Reports, 2019 AbstractLeptin regulates both feeding and glycaemia primarily through its receptors expressed on agouti-related peptide (AgRP) and pro-opiomelanocortin-expressing (POMC) neurons; however, it is unknown whether activity of these neuronal populations mediates the regulation of these processes.
Aykut Göktürk Üner +9 more
openaire +2 more sources