Results 31 to 40 of about 7,077 (114)
Palatability Can Drive Feeding Independent of AgRP Neurons [PDF]
Cell Metabolism, 2015 Feeding behavior is exquisitely regulated by homeostatic and hedonic neural substrates that integrate energy demand as well as the reinforcing and rewarding aspects of food. Understanding the net contribution of homeostatic and reward-driven feeding has become critical because of the ubiquitous source of energy-dense foods and the consequent obesity ...
Denis, Raphael Georges +22 more
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Hormone and glucose signalling in POMC and AgRP neurons
The Journal of Physiology, 2009 In the wake of the obesity pandemic, increased research efforts are under way to define how peripheral hormones and metabolites regulate energy homeostasis. The melanocortin system, comprising anorexigenic proopiomelanocortin (POMC) expressing neurons and orexigenic agouti‐related protein (AgRP)/neuropeptide Y (NPY) coexpressing neurons in the arcuate ...
Bengt F, Belgardt +2 more
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p53 and energy balance: meeting hypothalamic AgRP neurons [PDF]
Cell Stress, 2018 Cancer cells feature strong metabolic changes to cope with the high energy demand for cell growth and division. Given the importance of metabolic reprogramming in tumor development, it seems logical that tumor suppressors and oncogenes are also regulating the molecular pathways controlling these processes.
Omar Al-Massadi +2 more
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Agrp neuron activity is required for alcohol-induced overeating [PDF]
Nature Communications, 2017 Abstract Alcohol intake associates with overeating in humans. This overeating is a clinical concern, but its causes are puzzling, because alcohol (ethanol) is a calorie-dense nutrient, and calorie intake usually suppresses brain appetite signals.
Cains, S +4 more
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Ablation of AgRP neurons impairs adaption to restricted feeding
Molecular Metabolism, 2014 While the SCN controls the circadian clock, further evidence suggests the existence of a food-entrainable oscillator (FEO) that links behavior to changes in food availability such as during restricted feeding (RF). We found that the activity of AgRP/NPY neurons changed rhythmically during RF suggesting that these neurons are a component of the FEO.
Knight, Zachary, Tan, K, Friedman, JM
openaire +4 more sources
Hunger-Activated AgRP Neurons Inhibit MPOA Neurons Controlling Parenting [PDF]
The Journal of Neuroscience, 2019 Parental care comprises several behavioral components directed toward fostering the survival of offspring. It is particularly essential for mammalian species, because infants' growth depends almost entirely on adult care. Mammalian parents nurse or forage to supply food.
openaire +2 more sources
Amylin analogues as a novel perspective in anti‐obesity therapy
British Journal of Pharmacology, EarlyView.Abstract Public health systems face a major challenge because of the worldwide obesity epidemic. The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively “lean” country, the numbers are alarmingly high and have reached almost 50% of the adult population.
Thomas A. Lutz
wiley +1 more source
AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors [PDF]
Nature Neuroscience, 2012 It is not known whether behaviors unrelated to feeding are affected by hypothalamic regulators of hunger. We found that impairment of Agouti-related protein (AgRP) circuitry by either Sirt1 knockdown in AgRP-expressing neurons or early postnatal ablation of these neurons increased exploratory behavior and enhanced responses to cocaine.
Marcelo O, Dietrich +10 more
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Clinical Obesity, Volume 15, Issue 2, April 2025.Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton +4 more
wiley +1 more source
Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction
Obesity Reviews, EarlyView.Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey +7 more
wiley +1 more source