Results 51 to 60 of about 7,077 (114)
Rapid versus Delayed Stimulation of Feeding by the Endogenously Released AgRP Neuron Mediators GABA, NPY, and AgRP [PDF]
Cell Metabolism, 2013 Agouti-related peptide (AgRP) neurons of the hypothalamus release a fast transmitter (GABA) in addition to neuropeptides (neuropeptide Y [NPY] and Agouti-related peptide [AgRP]). This raises questions as to their respective functions. The acute activation of AgRP neurons robustly promotes food intake, while central injections of AgRP, NPY, or GABA ...
Krashes, Michael J. +3 more
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The NF‐κB Signalling Pathway: Mechanisms, Consequences and Therapeutic Targets
Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.ABSTRACT Nuclear Factor‐kappa B (NF‐κB) is a master transcriptional regulator orchestrating critical cellular processes, predominantly immunity and inflammation. However, its aberrant constitutive activation has emerged as a unifying pathogenetic hallmark across diverse malignancies, autoimmune disorders, and chronic inflammatory diseases.
Bherouz Pourdad, Arash Pourdad
wiley +1 more source
Mechanisms for AgRP neuron-mediated regulation of appetitive behaviors in rodents [PDF]
Physiology & Behavior, 2018 The obesity epidemic is a major health and economic burden facing both developed and developing countries worldwide. Interrogation of the central and peripheral mechanisms regulating ingestive behaviors have primarily focused on food intake, and in the process uncovered a detailed neuroanatomical framework controlling this behavior.
M. Alex Thomas, Bingzhong Xue
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Exploring the Potential of Calebin‐A in Targeting Obesity‐Related Genes and Pathways
Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.ABSTRACT Obesity is a global health crisis affecting millions, associated with metabolic disorders such as type 2 diabetes and cardiovascular disease. Calebin‐A, a bioactive compound derived from Curcuma species, has shown promise in managing obesity and its complications.
Ali Mahmoudi +4 more
wiley +1 more source
DRP1 IS REQUIRED FOR AGRP NEURONAL ACTIVITY AND FEEDING [PDF]
, 2020 Abstract The hypothalamic orexigenic Agouti-related peptide (AgRP)-expressing neurons are crucial for the regulation of whole-body energy homeostasis. Here, we show that fasting-induced AgRP neuronal activation is associated with dynamin-related peptide 1 (Drp1)-mediated mitochondrial fission and mitochondrial fatty ...
Sungho Jin +5 more
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Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.Abstract Disorders of gonadotropin pulsatility contribute to reproductive dysfunction in humans and are often associated with metabolic dysfunction. Hypogonadotropic hypogonadism is characterized by chronically insufficient gonadotropin hormone production, leading to reproductive and metabolic impairments, such as infertility and obesity.
Nimisha Nandankar +7 more
wiley +1 more source
AgRP to Kiss1 neuron signaling links nutritional state and fertility [PDF]
Proceedings of the National Academy of Sciences, 2017 Significance Women suffering from malnutrition and athletes with low body fat become infertile as a result of low gonadotropin secretion. Gonadotropin release is determined by a neural endocrine circuit; however, the metabolic cues that are responsible for attenuating this axis during starvation remain unclear.
Stephanie L, Padilla +8 more
openaire +2 more sources
Early adversity and the comorbidity between metabolic disease and psychopathology
The Journal of Physiology, Volume 604, Issue 11, Page 4338-4377, 1 June 2026.Abstract figure legend Hierarchical diagram representing the interplay between the genetic background and early life adversities and its effect on multiple physiological processes that ultimately impact on the risk for the comorbdity between psychopathology and cardiometabolic disorders.
Ameyalli Gómez‐Ilescas +1 more
wiley +1 more source
OPA1 in MC4R Neurons Regulates Dietary Fat Intake and Body Weight in Mice
The FASEB Journal, Volume 40, Issue 10, 31 May 2026.Soybean oil intake induces OPA1 expression in hypothalamic MC4R neurons, contributing to adaptive regulation of appetite. MC4R neuron‐specific OPA1 deficiency increases soybean oil consumption and leads to obesity, with a more pronounced effect in females.
Shigenobu Matsumura +10 more
wiley +1 more source
Loss of Striatal Bradykinin B2 Receptor Alters Anxiety and Motivational Behaviors in Male Mice
The FASEB Journal, Volume 40, Issue 10, 31 May 2026.Impaired signaling of the bradykinin B2 receptor (B2R) in dorsal striatal neurons decreases anxiety‐like behavior and sucrose preference while enhancing voluntary running in mice. These results reveal a novel role for B2R in dopaminergic circuits that modulate motivation and emotional behavior.
Mariana Rosolen Tavares +5 more
wiley +1 more source