Results 61 to 70 of about 7,077 (114)

Methodological Challenges for Ablation of BMPR1A in Hypothalamic Tanycytes—A Cautionary Tale

FASEB BioAdvances, Volume 8, Issue 5, May 2026.
Two strategies were used to target BMPR1A in adult hypothalamic tanycytes: (1) inducible Rax‐CreERT2 and (2) AAV‐Dio2‐iCre–mediated recombination. Although robust expression of reporter fluorescence and recombination gel analysis confirmed Cre activity in both models, BMPR1A expression was not reduced in targeted tanycytes.
Tianyi Tao, Noelle Leon‐Palmer, Sabrina DiPietro, Kristy L. Townsend   +3 more
wiley   +1 more source

Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin

Molecular Metabolism, 2014
The hormone ghrelin stimulates eating and helps maintain blood glucose upon caloric restriction. While previous studies have demonstrated that hypothalamic arcuate AgRP neurons are targets of ghrelin, the overall relevance of ghrelin signaling within intact AgRP neurons is unclear.
Wang, Qian, Liu, Chen, Uchida, Aki, Chuang, Jen-Chieh, Walker, Angela, Liu, Tiemin, Osborne-Lawrence, Sherri, Mason, Brittany L., Mosher, Christina, Berglund, Eric D., Elmquist, Joel K., Zigman, Jeffrey M.   +11 more
openaire   +2 more sources

AgRP neurons are not indispensable for body weight maintenance in adult mice. [PDF]

Cell Rep, 2023
Cai J, Chen J, Ortiz-Guzman J, Huang J, Arenkiel BR, Wang Y, Zhang Y, Shi Y, Tong Q, Zhan C.   +9 more
europepmc   +1 more source

mTORC1 Signaling in AgRP Neurons Is Not Required to Induce Major Neuroendocrine Adaptations to Food Restriction. [PDF]

Cells, 2023
de Souza GO, Teixeira PDS, Câmara NOS, Donato J.   +3 more
europepmc   +1 more source

GIRK2 potassium channels expressed by the AgRP neurons decrease adiposity and body weight in mice. [PDF]

PLoS Biol, 2023
Oh Y, Yoo ES, Ju SH, Kim E, Lee S, Kim S, Wickman K, Sohn JW.   +7 more
europepmc   +1 more source

Asprosin promotes feeding through SK channel-dependent activation of AgRP neurons. [PDF]

Sci Adv, 2023
Feng B, Liu H, Mishra I, Duerrschmid C, Gao P, Xu P, Wang C, He Y.   +7 more
europepmc   +1 more source

CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst. [PDF]

Biol Sex Differ, 2023
Zagmutt S, Mera P, González-García I, Ibeas K, Romero MDM, Obri A, Martin B, Esteve-Codina A, Soler-Vázquez MC, Bastias-Pérez M, Cañes L, Augé E, Pelegri C, Vilaplana J, Ariza X, García J, Martinez-González J, Casals N, López M, Palmiter R, Sanz E, Quintana A, Herrero L, Serra D.   +23 more
europepmc   +1 more source

Leucine deprivation results in antidepressant effects via GCN2 in AgRP neurons. [PDF]

Life Metab, 2023
Yuan F, Wu S, Zhou Z, Jiao F, Yin H, Niu Y, Jiang H, Chen S, Guo F.   +8 more
europepmc   +1 more source

Primary cilia in the hypothalamic AgRP neurons mediate metabolic effects of butyrate. [PDF]

Nat Commun
Rijal S, Yang DJ, Doan KV, Lyoo SH, Lee A, Choi YH, Shin DM, Kim KW.   +7 more
europepmc   +1 more source

An obligatory role for AgRP neurons in maintaining body temperature during time-restricted feeding. [PDF]

Metabolism
Su C, Cai J, Xu Y, Arenkiel BR, Tong Q.
europepmc   +1 more source