AgRP neurons control structure and function of the medial prefrontal cortex. [PDF]
Mol Psychiatry, 2022 Hypothalamic agouti-related peptide and neuropeptide Y-expressing (AgRP) neurons have a critical role in both feeding and non-feeding behaviors of newborn, adolescent, and adult mice, suggesting their broad modulatory impact on brain functions. Here we show that constitutive impairment of AgRP neurons or their peripubertal chemogenetic inhibition ...
Stutz B +13 more
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microRNA-33 controls hunger signaling in hypothalamic AgRP neurons. [PDF]
Nat CommunAbstractAgRP neurons drive hunger, and excessive nutrient intake is the primary driver of obesity and associated metabolic disorders. While many factors impacting central regulation of feeding behavior have been established, the role of microRNAs in this process is poorly understood.
Price NL +10 more
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Acute inhibition of hunger-sensing AgRP neurons promotes context-specific learning in mice [PDF]
Molecular Metabolism, 2023 Felicia Reed +2 more
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Melanocortin-3 receptor expression in AgRP neurons is required for normal activation of the neurons in response to energy deficiency [PDF]
Cell Reports, 2023 Naima S Dahir, Roger D Cone
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Growth hormone receptor (GHR) in AgRP neurons regulates thermogenesis in a sex-specific manner [PDF]
GeroScience, 2023 John J Kopchick +2 more
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Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation
Cell Metabolism, 2023 Chen W +13 more
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AgRP neuronal activity across feeding‐related behaviours [PDF]
European Journal of Neuroscience, 2021 Abstract AgRP neurons trigger one of the most potent orexigenic responses and are both necessary and sufficient for feeding. Recent technical advances for monitoring in vivo neuronal activity have revisited a previously well‐established model of AgRP neurons' feeding regulatory effects.
Gouveia, Ayden +2 more
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Drp1 is required for AgRP neuronal activity and feeding
eLife, 2021 The hypothalamic orexigenic Agouti-related peptide (AgRP)-expressing neurons are crucial for the regulation of whole-body energy homeostasis. Here, we show that fasting-induced AgRP neuronal activation is associated with dynamin-related peptide 1 (DRP1)-mediated mitochondrial fission and mitochondrial fatty acid utilization in AgRP
Sungho Jin +6 more
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AgRP Neurons Regulate Bone Mass [PDF]
Cell Reports, 2015 The hypothalamus has been implicated in skeletal metabolism. Whether hunger-promoting neurons of the arcuate nucleus impact the bone is not known. We generated multiple lines of mice to affect AgRP neuronal circuit integrity. We found that mice with Ucp2 gene deletion, in which AgRP neuronal function was impaired, were osteopenic.
Kim, Jae Geun +7 more
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Motivation to Eat—AgRP Neurons and Homeostatic Need [PDF]
Cell Metabolism, 2015 Activation of AgRP neurons potently induces feeding behaviors; however, whether this activity is involved in motivations of feeding behavior is unclear. A recent study in Nature (Betley et al., 2015) reports that AgRP neuron activity conditions learned behavior by transmitting a negative-valence signal: linking AgRP neurons to the preference of ...
Yang, Dengbao +2 more
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