Results 41 to 50 of about 20,021 (258)
Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective [PDF]
, 2019 The melanocortin-4 receptor (MC4R) can be endogenously activated by binding of melanocyte-stimulating hormones (MSH), which mediates anorexigenic effects. In contrast, the agouti-related peptide (AgRP) acts as an endogenous inverse agonist and suppresses
Biebermann, Heike +10 more
core +1 more source
Science-Business eXchange, 2012 New York researchers have identified GPR17 as a potentially druggable target on AGRP neurons, which are known to regulate factors relevant to obesity. The findings open up a new pathway to mine for therapeutic strategies against a cell population for which earlier targeting strategies have had little success.
openaire +1 more source
PDK1-FoxO1 pathway in AgRP neurons of arcuate nucleus promotes bone formation via GHRH-GH-IGF1 axis
Molecular Metabolism, 2017 Objective: In the hypothalamic arcuate nucleus (ARC), orexigenic agouti-related peptide (AgRP) neurons regulate feeding behavior and energy homeostasis, functions connected to bone metabolism.
Hideyuki Sasanuma +4 more
doaj +1 more source
Heparin Increases Food Intake through AgRP Neurons [PDF]
Cell Reports, 2017 Although the widely used anticoagulant drug heparin has been shown to have many other biological functions independent of its anticoagulant role, its effects on energy homeostasis are unknown. Here, we demonstrate that heparin level is negatively associated with nutritional states and that heparin treatment increases food intake and body weight gain ...
Canjun Zhu +17 more
openaire +3 more sources
On the syntactic derivation of negative sentence adverbials [PDF]
, 1993 We consider recent Government-Binding work on sentential negation, e.g. by Pollock, and evaluate a fundamental assumption made about the syntax of negative clauses.
Rowlett, PA
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Negative inversion, negative concord and sentential negation in the history of English [PDF]
, 2012 It is claimed in van Kemenade (2000: 62) that clauses with initial negative constituents are a context in which subject–verb inversion occurs throughout the history of English.
Chomsky +16 more
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EXONEST: Bayesian Model Selection Applied to the Detection and Characterization of Exoplanets Via Photometric Variations [PDF]
, 2014 EXONEST is an algorithm dedicated to detecting and characterizing the photometric signatures of exoplanets, which include reflection and thermal emission, Doppler boosting, and ellipsoidal variations.
Angerhausen, Daniel +2 more
core +3 more sources
Metabolic effects of diets differing in glycaemic index depend on age and endogenous GIP [PDF]
, 2009 Aims/hypothesis High- vs low-glycaemic index (GI) diets unfavourably affect body fat mass and metabolic markers in rodents. Different effects of these diets could be age-dependent, as well as mediated, in part, by carbohydrate-induced stimulation of ...
A. Abdelrahman +45 more
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Identification of AgRP cells in the murine hindbrain that drive feeding
Molecular MetabolismObjective: The central melanocortin system is essential for the regulation of food intake and body weight. Agouti-related protein (AgRP) is the sole orexigenic component of the central melanocortin system and is conserved across mammalian species.
Tomas P. Bachor +12 more
doaj +1 more source
eLife, 2015 Agouti-related-peptide (AgRP) neurons—interoceptive neurons in the arcuate nucleus of the hypothalamus (ARC)—are both necessary and sufficient for driving feeding behavior. To better understand the functional roles of AgRP neurons, we performed optetrode
Yael Mandelblat-Cerf +6 more
doaj +1 more source