Results 41 to 50 of about 9,029 (175)

Sustained NPY signaling enables AgRP neurons to drive feeding

eLife, 2019
Artificial stimulation of Agouti-Related Peptide (AgRP) neurons promotes intense food consumption, yet paradoxically during natural behavior these cells are inhibited before feeding begins.
Yiming Chen, Rachel A Essner, Seher Kosar, Oliver H Miller, Yen-Chu Lin, Sheyda Mesgarzadeh, Zachary A Knight   +6 more
doaj   +1 more source

Does an acute bout of high intensity interval exercise suppress appetite in obese women?

Pedagogy of Physical Culture and Sports, 2020
Purpose: The aim of this study was to investigate the 24 hour response of appetite and energy intake and the amount of Agouti-Related Protein to the high intensity interval exercise in obese untrained women.
Sepideh Khalaj, Bahman Mirzaei
doaj   +1 more source

Syncing Health Timing: Exploring the Interplay of Circadian Rhythms, Obesity, and Cardiovascular Diseases

Food Safety and Health, EarlyView.
Circadian rhythm disruption impairs metabolic regulation, appetite control, and vascular function, promoting obesity and cardiovascular diseases. Evidence highlights a bidirectional relationship where metabolic disorders further disturb circadian timing.
Ghizal Fatima, István Dalmadi, Anna Jánosi, Krisztina Takács, Eszter Halmy   +4 more
wiley   +1 more source

Inhibition of Itch by Hunger and AgRP Neuron Activity

Neuroscience, 2020
Unpleasant somatosensory stimuli such as pain and itch can interrupt normal behavior. But survival can depend on resuming normal behavior before these challenges are fully resolved. The neural mechanisms that prioritize behavior when individuals are challenged with unpleasant somatosensory sensations, however, are not fully understood.
Amber L, Alhadeff, Onyoo, Park, Elen, Hernandez, J Nicholas, Betley   +3 more
openaire   +3 more sources

Age-specific regulation of sociability by hypothalamic Agrp neurons [PDF]

Current Biology
Marcelo Zimmer, Marcelo Dietrich, Jeremy Bober   +2 more
exaly   +2 more sources

The role of GluN2A and GluN2B NMDA receptor subunits in AgRP and POMC neurons on body weight and glucose homeostasis

Molecular Metabolism, 2015
Objective: Hypothalamic agouti-related peptide (AgRP) and pro-opiomelanocortin (POMC) expressing neurons play critical roles in control of energy balance.
Aykut Üner, Gabriel H.M. Gonçalves, Wenjing Li, Matheus Porceban, Nicole Caron, Milena Schönke, Eric Delpire, Kenji Sakimura, Christian Bjørbæk   +8 more
doaj   +1 more source

TET3 epigenetically controls feeding and stress response behaviors via AGRP neurons

The Journal of Clinical Investigation, 2022
The TET family of dioxygenases promote DNA demethylation by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine (5hmC). Hypothalamic agouti-related peptide–expressing (AGRP-expressing) neurons play an essential role in driving feeding, while also ...
Di Xie, Bernardo Stutz, Feng Li, Fan Chen, Haining Lv, Matija Sestan-Pesa, Jonatas Catarino, Jianlei Gu, Hongyu Zhao, Christopher E. Stoddard, Gordon G. Carmichael, Marya Shanabrough, Hugh S. Taylor, Zhong-Wu Liu, Xiao-Bing Gao, Tamas L. Horvath, Yingqun Huang   +16 more
doaj   +1 more source

Angiotensin AT1A receptor signal switching in Agouti-related peptide neurons mediates metabolic rate adaptation during obesity

Cell Reports, 2023
Summary: Resting metabolic rate (RMR) adaptation occurs during obesity and is hypothesized to contribute to failed weight management. Angiotensin II (Ang-II) type 1 (AT1A) receptors in Agouti-related peptide (AgRP) neurons contribute to the integrative ...
Kirthikaa Balapattabi, Yavuz Yavuz, Jingwei Jiang, Guorui Deng, Natalia M. Mathieu, McKenzie L. Ritter, Megan A. Opichka, John J. Reho, John D. McCorvy, Pablo Nakagawa, Lisa L. Morselli, Gary C. Mouradian, Jr., Deniz Atasoy, Huxing Cui, Matthew R. Hodges, Curt D. Sigmund, Justin L. Grobe   +16 more
doaj   +1 more source

Monogenic and syndromic obesity in children: Clinical recognition, genetics, and precision management

Pediatric Investigation, EarlyView.
Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil, Eugene Feigin, Hussein Zaitoon   +2 more
wiley   +1 more source

AgRP neurons trigger long-term potentiation and facilitate food seeking

Translational Psychiatry, 2021
Sufficient feeding is essential for animals’ survival, which requires a cognitive capability to facilitate food seeking, but the neurobiological processes regulating food seeking are not fully understood.
Chunmei Wang, Wenjun Zhou, Yang He, Tiffany Yang, Pingwen Xu, Yongjie Yang, Xing Cai, Julia Wang, Hesong Liu, Meng Yu, Chen Liang, Tingting Yang, Hailan Liu, Makoto Fukuda, Qingchun Tong, Qi Wu, Zheng Sun, Yanlin He, Yong Xu   +18 more
doaj   +1 more source