Results 41 to 50 of about 8,978 (173)
Does an acute bout of high intensity interval exercise suppress appetite in obese women?
Pedagogy of Physical Culture and Sports, 2020 Purpose: The aim of this study was to investigate the 24 hour response of appetite and energy intake and the amount of Agouti-Related Protein to the high intensity interval exercise in obese untrained women.
Sepideh Khalaj, Bahman Mirzaei
doaj +1 more source
Regulation of substrate utilization and adiposity by Agrp neurons [PDF]
Nature Communications, 2019 Abstract The type of nutrient utilized by the organism at any given time—substrate utilization—is a critical component of energy metabolism. The neuronal mechanisms involved in the regulation of substrate utilization in mammals are largely unknown.
João Paulo Cavalcanti-de-Albuquerque +3 more
openaire +3 more sources
Molecular Metabolism, 2015 Objective: Hypothalamic agouti-related peptide (AgRP) and pro-opiomelanocortin (POMC) expressing neurons play critical roles in control of energy balance.
Aykut Üner +8 more
doaj +1 more source
TET3 epigenetically controls feeding and stress response behaviors via AGRP neurons
The Journal of Clinical Investigation, 2022 The TET family of dioxygenases promote DNA demethylation by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine (5hmC). Hypothalamic agouti-related peptide–expressing (AGRP-expressing) neurons play an essential role in driving feeding, while also ...
Di Xie +16 more
doaj +1 more source
BMC Neuroscience, 2002 Background Several lines of evidence strongly suggest that agouti-related peptide (AGRP) plays a key role in the regulation of metabolic function but ablation of the AGRP gene has no apparent effect on metabolic function.
Mastaitis Jason W +4 more
doaj +1 more source
Pediatric Investigation, EarlyView.Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil +2 more
wiley +1 more source
Amylin analogues as a novel perspective in anti‐obesity therapy
British Journal of Pharmacology, EarlyView.Abstract Public health systems face a major challenge because of the worldwide obesity epidemic. The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively “lean” country, the numbers are alarmingly high and have reached almost 50% of the adult population.
Thomas A. Lutz
wiley +1 more source
Inhibition of Itch by Hunger and AgRP Neuron Activity
Neuroscience, 2020 Unpleasant somatosensory stimuli such as pain and itch can interrupt normal behavior. But survival can depend on resuming normal behavior before these challenges are fully resolved. The neural mechanisms that prioritize behavior when individuals are challenged with unpleasant somatosensory sensations, however, are not fully understood.
Amber L, Alhadeff +3 more
openaire +3 more sources
Cell Reports, 2023 Summary: Resting metabolic rate (RMR) adaptation occurs during obesity and is hypothesized to contribute to failed weight management. Angiotensin II (Ang-II) type 1 (AT1A) receptors in Agouti-related peptide (AgRP) neurons contribute to the integrative ...
Kirthikaa Balapattabi +16 more
doaj +1 more source
Clinical Obesity, Volume 15, Issue 2, April 2025.Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton +4 more
wiley +1 more source