Results 61 to 70 of about 8,978 (173)

Cilia in Nervous System Development, Function, and Disease

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Cilia are evolutionarily conserved organelles that function as essential sensory and motility platforms in the nervous system. This review outlines key cilia‐dependent signaling pathways and their roles in neural development and function. Furthermore, it highlights how ciliary dysfunction can lead to a variety of neurological disorders, known as ...
Qingchao Li, Anqi Zhang, Ting Song
wiley   +1 more source

Hormone and glucose signalling in POMC and AgRP neurons

The Journal of Physiology, 2009
In the wake of the obesity pandemic, increased research efforts are under way to define how peripheral hormones and metabolites regulate energy homeostasis. The melanocortin system, comprising anorexigenic proopiomelanocortin (POMC) expressing neurons and orexigenic agouti‐related protein (AgRP)/neuropeptide Y (NPY) coexpressing neurons in the arcuate ...
Bengt F, Belgardt, Tomoo, Okamura, Jens C, Brüning   +2 more
openaire   +3 more sources

Altered features of neurotransmitters: NPY, α-MSH, and AgRP in type 2 diabetic patients with hypertension

Journal of International Medical Research, 2020
Objective To investigate the features of neuropeptide Y (NPY), α-melanocyte stimulating hormone (α-MSH), and agouti-related protein (AgRP) in type 2 diabetes mellitus (T2DM) patients with hypertension.
Baoxin Li, Shuang Ma, Shuqin Guo, Na Li, Dandan Liu, He Wang, Na Zhai, Yunliang Zhang   +7 more
doaj   +1 more source

Food intake regulation during pregnancy and lactation in mice with reduced activity of the melanocortin system

Вавиловский журнал генетики и селекции, 2016
Hypothalamic melanortin receptor (MCR) activation inhibits appetite. Neuropeptide Y (NPY) and Agouti Related Protein (AgRP) are coexpressed in some hypothalamic neurons and stimulate feeding, NPY via inhibition of MCR-expressing neurons, and AgRP via ...
E. N. Makarova, I. V. Romanova, N. M. Bazhan   +2 more
doaj   +1 more source

The development of type 2 diabetes amongst sibling pairs in the South‐South region of Nigeria: The effect of genetics, environment and lifestyle

Diabetic Medicine, Volume 43, Issue 6, June 2026.
Abstract Introduction Type 2 diabetes is a complex condition with a multifactorial pathogenesis. The pathogenesis is considered to be polygenic due to complex interactions between genetic/epigenetic and environmental factors. The aim of this study is to determine the genetic, environmental and lifestyle factors associated with the development of type 2
Sunny Chinenye, Ibi Erekosima, Adrian H. Heald, Gesiye Bozimo, Simon G. Anderson, Samuel Seidu, Kariba Akhidue, Adaeze Ugwu, Chioma Unachukwu, Ibitrokoemi Korubo, Kingsley Chukwuemeka Patrick‐Iwuanyanwu, Victoria Gomba, Uwoma Batubo, Victoria Akanatei, Victor Ken‐Uba, Iyeopu Siminialayi, Sokiprim Akoko, Justin Ideozu, Hamilton Opurum   +18 more
wiley   +1 more source

PGC-1α expression in murine AgRP neurons regulates food intake and energy balance

Molecular Metabolism, 2016
Objective: Food intake and whole-body energy homeostasis are controlled by agouti-related protein (AgRP) and pro-opiomelanocortin (POMC) neurons located in the arcuate nucleus of the hypothalamus.
Jonathan F. Gill, Julien Delezie, Gesa Santos, Christoph Handschin   +3 more
doaj   +1 more source

Chronic glucocorticoid treatment induces hepatic lipid accumulation and hyperinsulinaemia in part through actions on AgRP neurons

Scientific Reports, 2021
Glucocorticoids (GCs) are widely prescribed anti-inflammatory medicines, but their use can lead to metabolic side-effects. These may occur through direct actions of GCs on peripheral organs, but could also be mediated by the hypothalamic AgRP neurons ...
Erika Harno, Charlotte Sefton, Jonathan R. Wray, Tiffany-Jayne Allen, Alison Davies, Anthony P. Coll, Anne White   +6 more
doaj   +1 more source

The NF‐κB Signalling Pathway: Mechanisms, Consequences and Therapeutic Targets

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Nuclear Factor‐kappa B (NF‐κB) is a master transcriptional regulator orchestrating critical cellular processes, predominantly immunity and inflammation. However, its aberrant constitutive activation has emerged as a unifying pathogenetic hallmark across diverse malignancies, autoimmune disorders, and chronic inflammatory diseases.
Bherouz Pourdad, Arash Pourdad
wiley   +1 more source

Role of POMC and AgRP neuronal activities on glycaemia in mice [PDF]

Scientific Reports, 2019
AbstractLeptin regulates both feeding and glycaemia primarily through its receptors expressed on agouti-related peptide (AgRP) and pro-opiomelanocortin-expressing (POMC) neurons; however, it is unknown whether activity of these neuronal populations mediates the regulation of these processes.
Aykut Göktürk Üner, Onur Keçik, Paula G. F. Quaresma, Thiago M. De Araujo, Hyon Lee, Wenjing Li, Hyun Jeong Kim, Michelle Chung, Christian Bjørbæk, Young-Bum Kim   +9 more
openaire   +2 more sources

Palmitate-induced autophagy liberates monounsaturated fatty acids and increases Agrp expression in hypothalamic cells

Animal Cells and Systems, 2019
Fatty acids regulate food intake, although the exact mechanism remains unknown. Emerging evidence suggests that intracellular free fatty acids generated by starvation-induced autophagy regulate food intake. Starvation for 6 h elevated fatty acids such as
Seokjae Park, Tae Seok Oh, Seolsong Kim, Eun-Kyoung Kim   +3 more
doaj   +1 more source