Results 81 to 90 of about 8,978 (173)

Action of Neurotransmitter: A Key to Unlock the AgRP Neuron Feeding Circuit

Frontiers in Neuroscience, 2013
The current obesity epidemic and lack of efficient therapeutics demand a clear understanding of the mechanism underlying body weight regulation. Despite intensive research focus on obesity pathogenesis, an effective therapeutic strategy to treat and cure
Tiemin eLiu, Qian eWang, Eric D Berglund, Qingchun eTong   +3 more
doaj   +1 more source

Chemogenetic engagement of different GPCR signaling pathways segregates the orexigenic activity from the control of whole-body glucose metabolism by AGRP neurons

Molecular Metabolism
Objective: The control of energy balance involves neural circuits in the central nervous system, including AGRP neurons in the arcuate nucleus of the hypothalamus (ARC).
Valerie Espinal Abreu, Rachel Barnes, Vishnupriya Borra, Jennifer Schurdak, Diego Perez-Tilve   +4 more
doaj   +1 more source

RESTING PLASMA AgRP LEVELS RESPONSE TO EXERCISE-CONJUGATED DIET AND ONLY DIET IN OVERWEIGHT AND OBESE SEDENTARY FEMALES

Biology of Sport, 2012
Agouti-related peptide (AgRP) is an orexigenic neuropeptide produced mainly in the arcuate nucleus (ARC) of the hypothalamus, which leads to positive energy balance.
Mahmoud Delphan, Amir Rashidlamir, Firoozeh Delphan   +2 more
doaj  

FTO promotes weight gain via altering Kif1a splicing and axonal vesicle trafficking in AgRP neurons

The EMBO Journal
N6-methyladenosine (m6A) is an abundant chemical RNA modification involved in the regulation of many biological processes. The m6A demethylase FTO (fat mass and obesity-associated protein) is known to affect body weight, but its systemic context and ...
Daisuke Kohno, Reika Kawabata-Iwakawa, Sotaro Ichinose, Shigetomo Suyama, Kazuto Ohashi, Winda Ariyani, Tetsushi Sadakata, Hiromi Yokota-Hashimoto, Ryosuke Kobayashi, Takuro Horii, Vina Yanti Susanti, Ayumu Konno, Haruka Tsuneoka, Chiharu Yoshikawa, Sho Matsui, Akihiro Harada, Toshihiko Yada, Izuho Hatada, Hirokazu Hirai, Masahiko Nishiyama, Tsutomu Sasaki, Tadahiro Kitamura   +21 more
doaj   +1 more source

AgRP neurons shape the sperm small RNA payload

Scientific Reports
Abstract Paternal dietary patterns and obesity can affect offspring through epigenetic signals in sperm RNA. By activating hypothalamic Agouti-related peptide (AgRP) neurons in mice to simulate obesity’s effects, we observed changes in the small noncoding RNA payload of sperm.
Iasim Tahiri, Sergio R. Llana, Francisco Díaz-Castro, Marc Claret, Arnaud Obri   +4 more
openaire   +3 more sources

Effect of endurance training on plasma levels of AGRP and HOMA-IR in diabetic rats

Turkish Journal of Kinesiology, 2017
The hypothalamus is a strong central controller of appetite that secretes different neuropeptides including AGRP. Plasma levels of AGRP are effective in controlling obesity and hunger.
Javad Mehrabani, Maryam Sedighianrad, Nasrin Ramezani, Hadi Nobari, Reza Bagheri   +4 more
doaj   +2 more sources

Microglia are required for developmental specification of AgRP innervation in the hypothalamus of offspring exposed to maternal high-fat diet during lactation

eLife
Agouti-related peptide (AgRP) neurons in the arcuate nucleus of the hypothalamus respond to multiple metabolic signals and distribute neuroendocrine information to other brain regions such as the paraventricular hypothalamic nucleus (PVH), which plays a ...
Haley N Mendoza-Romero, Jessica E Biddinger, Michelle N Bedenbaugh, Richard Simerly   +3 more
doaj   +1 more source

AGRP Gene [PDF]

, 2020
openaire   +1 more source

Modeling the effects of genetic- and diet-induced obesity on melanoma progression in zebrafish

Disease Models & Mechanisms, 2023
Emily Montal, Dianne Lumaquin, Yilun Ma, Shruthy Suresh, Richard M. White   +4 more
doaj   +1 more source

AGRP wt Allele [PDF]

, 2020
openaire   +1 more source