Results 81 to 90 of about 20,021 (258)
Вавиловский журнал генетики и селекции, 2016 Hypothalamic melanortin receptor (MCR) activation inhibits appetite. Neuropeptide Y (NPY) and Agouti Related Protein (AgRP) are coexpressed in some hypothalamic neurons and stimulate feeding, NPY via inhibition of MCR-expressing neurons, and AgRP via ...
E. N. Makarova +2 more
doaj +1 more source
Hedgehog Pathway Activation Alters Ciliary Signaling in Primary Hypothalamic Cultures [PDF]
, 2019 Primary cilia dysfunction has been associated with hyperphagia and obesity in both ciliopathy patients and mouse models of cilia perturbation. Neurons throughout the brain possess these solitary cellular appendages, including in the feeding centers of ...
Antonellis, Patrick J. +7 more
core +1 more source
<strong>Bridging Energy Need and Feeding Behavior: The Impact of eIF2α Phosphorylation in AgRP Neurons</strong> [PDF]
, 2023 Kwang Kon Kim +13 more
openalex +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor +4 more
wiley +1 more source
Discovering the Value of Multidisciplinary Approaches to Research: Insights from a Sabbatical [PDF]
, 2009 In this informal report, I outline my research efforts, collaborations, and other experiences while participating in the Naval Research Laboratory (NRL)'s Advanced Graduate Research Program (AGRP), aka Sabbatical, from October 2008 through September 2009.
Bentrem, Frank W.
core
The Journal of Physiology, EarlyView.Abstract figure legend Central leptin signalling blockade induces early metabolic dysfunction. Intracerebroventricular infusion of a leptin receptor antagonist (SLA) in rats disrupts hypothalamic leptin signalling, leading to reduced signal transducer and activator of transcription 3 (STAT3) activation, decreased Socs3 and Pomc expression, and ...
Cristina Pintado +16 more
wiley +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 5184-5194, June 2026.ABSTRACT Aims Semaglutide is a GLP‐1 receptor agonist for the treatment of type 2 diabetes and obesity. Its clinical effects are well established, but the underlying mechanisms remain unclear. This study aims to use computational modelling to generate hypotheses about semaglutide's long‐term metabolic (body weight, net energy intake, blood glucose ...
Vivan C. W. Kennis, Natal A. W. van Riel
wiley +1 more source
A Phase-based Approach to Rightward Movement in Comparatives [PDF]
, 2008 In this article, I aim at providing a phase-based explanation of extraposition phenomena in attributive comparatives. Conforming to a semantic requirement, the than-expression is an obligatory complement of the functional Degree head. However, there is
Kántor, Gergely
core
From obesity resistance to obesity prediction and prevention? [PDF]
, 2016 Comment on: Regulation of hypothalamic neuropeptides gene expression in diet induced obesity resistant rats: possible targets for obesity prediction?
Cassano, Tommaso, Gaetani, Silvana
core +4 more sources
COORDINATED INTERPLAY BETWEEN AGRP AND POMC NEURONS MODULATES SYSTEMIC METABOLISM [PDF]
, 2023 Alain De Solis +14 more
openalex +1 more source