Results 71 to 80 of about 9,029 (175)

Chronic glucocorticoid treatment induces hepatic lipid accumulation and hyperinsulinaemia in part through actions on AgRP neurons

Scientific Reports, 2021
Glucocorticoids (GCs) are widely prescribed anti-inflammatory medicines, but their use can lead to metabolic side-effects. These may occur through direct actions of GCs on peripheral organs, but could also be mediated by the hypothalamic AgRP neurons ...
Erika Harno, Charlotte Sefton, Jonathan R. Wray, Tiffany-Jayne Allen, Alison Davies, Anthony P. Coll, Anne White   +6 more
doaj   +1 more source

Understanding the Molecular Processes of Obesity and the Anti‐Obesity Properties of Bioactive Substances Found in Tea

Phytochemicals in Food and Medicine, Volume 1, Issue 3, September 2026.
ABSTRACT Obesity, a severe worldwide health concern, is characterized as an excessive deposit of fat in the human body. It has various ramifications that endanger human health and increase the financial expense. Obesity raises the risk of several illnesses, notably cardiovascular disease, NALFD, and diabetes, and has been associated with shorter ...
Sakhawat Riaz, Fan Wenni, Danish Kamal, Umber Mubeen, Abul Hassan, Arslan Ahmed, Munir Ahmed   +6 more
wiley   +1 more source

Palatability Can Drive Feeding Independent of AgRP Neurons [PDF]

Cell Metabolism, 2015
Feeding behavior is exquisitely regulated by homeostatic and hedonic neural substrates that integrate energy demand as well as the reinforcing and rewarding aspects of food. Understanding the net contribution of homeostatic and reward-driven feeding has become critical because of the ubiquitous source of energy-dense foods and the consequent obesity ...
Denis, Raphael Georges, Joly-Amado, Aurélie, Webber, Emily, Langlet, Fanny, Schaeffer, Marie, Padilla, Stéphanie, Cansell, Céline, Dehouck, Bénédicte, Castel, Julien, Delbes, Anne-Sophie, Martinez, Sarah, Lacombe, Amélie, Rouch, Claude, Kassis, Nadim, Fehrentz, Jean-Alain, Martinez, Jean, Verdie, Pascal, Hnasko, Thomas S., Palmiter, Richard D., Krashes, Michael J., Güler, Ali D., Magnan, Christophe, Luquet, Serge   +22 more
openaire   +7 more sources

Obesity Disrupts CtBP2‐Mediated Maintenance of Transcriptional Equilibrium in Hypothalamic Feeding Circuitry

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
CtBP2, a transcriptional corepressor with metabolite sensing capabilities, maintains feeding homeostasis by preventing excessive food intake in the hypothalamic feeding center. CtBP2 limits food intake by inhibiting KLF4 within AgRP neurons and by promoting the inhibitory influence of POMC neurons on AgRP neurons.
Wanpei Chen, Kenta Kainoh, Kenji Saito, Takaaki Matsuda, Daichi Yamazaki, Yuto Kobari, Ayumi Nakata, Nao Aono‐Soma, Takafumi Miyamoto, Yuki Murayama, Yoko Sugano, Yoshinori Osaki, Hitoshi Iwasaki, Takashi Matsuzaka, Hitoshi Shimano, Motohiro Sekiya   +15 more
wiley   +1 more source

Activation of GHSRs Facilitates the Excitability of Dentate Gyrus Granule Cells and Short‐Term Spatial Memory via Multiple Ionic and Signaling Mechanisms

Advanced Biology, Volume 10, Issue 8, August 2026.
Ghrelin excites the dentate gyrus (DG) granule cells via GHSR‐mediated modulation of diverse ionic channels and activation of D1R, cAMP, and EPAC2. Similarly, overnight calorie restriction alters neuronal excitability in a ghrelin‐dependent manner. Infusion of ghrelin directly into the DG improves short‐term spatial memory in the Y‐maze, providing ...
Chidiebele S. Oraegbuna, Phani K. Kola, Simon L. Griggs, Saobo Lei   +3 more
wiley   +1 more source

Proteomic signatures of protected APOE ε4 carriers reveal causal pathways associated with delayed Alzheimer's disease onset

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION APOE ε4 is the strongest common genetic risk factor for Alzheimer's disease (AD), yet many carriers remain cognitively unimpaired into late life. We tested whether protected ε4‐first plasma proteomics could identify proteins associated with delayed clinical onset.
Yann Le Guen, Junyoung Park, Andrés Peña‐Tauber, Michael D. Greicius   +3 more
wiley   +1 more source

Interventions for Unhealthy Eating Patterns of Resident Otolaryngologists on Call

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 4, August 2026.
ABSTRACT Objectives Resident physicians commonly experience elevated stress levels and disrupted sleep while on call. Many also report intense cravings for comfort food, typically high in fat, sugar, and salt. The objective of this pilot study was to explore the physiological and psychological factors contributing to the desire for unhealthy food among
Hannah G. Luk, Harold Pine
wiley   +1 more source

Widespread expression of Agouti-related protein (AGRP) in the chicken: a possible involvement of AGRP in regulating peripheral melanocortin systems in the chicken

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2000
Agouti-related protein (AGRP) is a naturally occurring antagonist of melanocortin action. It is expressed mainly in the arcuate nucleus where it plays an important role in the hypothalamic control of feeding and energy homeostasis by antagonism of central melanocortin 4 receptors in mammals.
Takeuchi, Sakae, Teshigawara, Kiyoshi, Takahashi, Sumio   +2 more
openaire   +2 more sources

The Clinical Phenotype and Genetic Analysis of Monogenic Non Syndromic Obesity Caused by MC4R Gene Variation

Molecular Genetics &Genomic Medicine, Volume 14, Issue 8, August 2026.
A novel MC4R mutation (c.185A > G) was identified in a 10‐year‐old girl with severe obesity and hyperinsulinemia. Retrospective analysis of 64 pediatric cases revealed that mutation location influences BMI, modulated by underlying disease status, demonstrating that the genotype–phenotype relationship in MC4R‐associated obesity is clinically context ...
Xin Li, Xiaotian Wang, Xin Liu, Shuping Wang, Wentao Yang   +4 more
wiley   +1 more source

AgRP Neurons Require Carnitine Acetyltransferase to Regulate Metabolic Flexibility and Peripheral Nutrient Partitioning

Cell Reports, 2018
Summary: AgRP neurons control peripheral substrate utilization and nutrient partitioning during conditions of energy deficit and nutrient replenishment, although the molecular mechanism is unknown.
Alex Reichenbach, Romana Stark, Mathieu Mequinion, Raphael R.G. Denis, Jeferson F. Goularte, Rachel E. Clarke, Sarah H. Lockie, Moyra B. Lemus, Greg M. Kowalski, Clinton R. Bruce, Cheng Huang, Ralf B. Schittenhelm, Randall L. Mynatt, Brian J. Oldfield, Matthew J. Watt, Serge Luquet, Zane B. Andrews   +16 more
doaj   +1 more source