Results 71 to 80 of about 20,021 (258)
Food-induced dopamine signaling in AgRP neurons promotes feeding
Cell Reports, 2022 Obesity comorbidities such as diabetes and cardiovascular disease are pressing public health concerns. Overconsumption of calories leads to weight gain; however, neural mechanisms underlying excessive food consumption are poorly understood. Here, we demonstrate that dopamine receptor D1 (Drd1) expressed in the agouti-related peptide/neuropeptide Y ...
Qi Zhang +10 more
openaire +2 more sources
Diabetic Medicine, EarlyView.Abstract Introduction Type 2 diabetes is a complex condition with a multifactorial pathogenesis. The pathogenesis is considered to be polygenic due to complex interactions between genetic/epigenetic and environmental factors. The aim of this study is to determine the genetic, environmental and lifestyle factors associated with the development of type 2
Sunny Chinenye +18 more
wiley +1 more source
A Small Potassium Current in AgRP/NPY Neurons Regulates Feeding Behavior and Energy Metabolism
Cell Reports, 2016 Neurons that co-express agouti-related peptide (AgRP) and neuropeptide Y (NPY) are indispensable for normal feeding behavior. Firing activities of AgRP/NPY neurons are dynamically regulated by energy status and coordinate appropriate feeding behavior to ...
Yanlin He +12 more
doaj +1 more source
AgRP neurons trigger long-term potentiation and facilitate food seeking
Translational Psychiatry, 2021 Sufficient feeding is essential for animals’ survival, which requires a cognitive capability to facilitate food seeking, but the neurobiological processes regulating food seeking are not fully understood.
Chunmei Wang +18 more
doaj +1 more source
, 2003 This is a manuscript based on conference presentations.
Vainikka, Anne Marjatta
core +1 more source
Early adversity and the comorbidity between metabolic disease and psychopathology
The Journal of Physiology, EarlyView.Abstract figure legend Hierarchical diagram representing the interplay between the genetic background and early life adversities and its effect on multiple physiological processes that ultimately impact on the risk for the comorbdity between psychopathology and cardiometabolic disorders.
Ameyalli Gómez‐Ilescas +1 more
wiley +1 more source
Regulation of substrate utilization and adiposity by Agrp neurons [PDF]
Nature Communications, 2019 Abstract The type of nutrient utilized by the organism at any given time—substrate utilization—is a critical component of energy metabolism. The neuronal mechanisms involved in the regulation of substrate utilization in mammals are largely unknown.
João Paulo Cavalcanti-de-Albuquerque +3 more
openaire +3 more sources
Evidence That Agouti-Related Peptide May Directly Regulate Kisspeptin Neurons in Male Sheep
Metabolites, 2021 Agouti-related peptide (AgRP) neurons, which relay information from peripheral metabolic signals, may constitute a key central regulator of reproduction.
Christina M. Merkley +3 more
doaj +1 more source
Obesity Induces Hypothalamic Endoplasmic Reticulum Stress and Impairs Proopiomelanocortin (POMC) Post-translational Processing [PDF]
, 2013 It was shown previously that abnormal prohormone processing or inactive proconverting enzymes that are responsible for this processing cause profound obesity.
Cakir, Isin +6 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney +4 more
wiley +1 more source