Results 51 to 60 of about 8,978 (173)

UCP2 mediates mitochondrial dynamics to induce AgRP neuronal activity

Molecular Metabolism
Objectives: The hypothalamic agouti-related protein (AgRP)- expressing neurons regulate feeding and whole-body energy homeostasis. A growing body of evidence indicates that changes in mitochondrial dynamics, such as fission and fusion, play a crucial ...
Sungho Jin, Nal Ae Yoon, Zhong-Wu Liu, Ciro Menale, Jung Dae Kim, Nadia Diano, Sabrina Diano   +6 more
doaj   +1 more source

AgRP neurons trigger long-term potentiation and facilitate food seeking

Translational Psychiatry, 2021
Sufficient feeding is essential for animals’ survival, which requires a cognitive capability to facilitate food seeking, but the neurobiological processes regulating food seeking are not fully understood.
Chunmei Wang, Wenjun Zhou, Yang He, Tiffany Yang, Pingwen Xu, Yongjie Yang, Xing Cai, Julia Wang, Hesong Liu, Meng Yu, Chen Liang, Tingting Yang, Hailan Liu, Makoto Fukuda, Qingchun Tong, Qi Wu, Zheng Sun, Yanlin He, Yong Xu   +18 more
doaj   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Evidence That Agouti-Related Peptide May Directly Regulate Kisspeptin Neurons in Male Sheep

Metabolites, 2021
Agouti-related peptide (AgRP) neurons, which relay information from peripheral metabolic signals, may constitute a key central regulator of reproduction.
Christina M. Merkley, Sydney L. Shuping, Jeffrey R. Sommer, Casey C Nestor   +3 more
doaj   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Chronic attenuation of brain leptin signalling is associated with early metabolic dysfunction in lean rats

The Journal of Physiology, EarlyView.
Abstract figure legend Central leptin signalling blockade induces early metabolic dysfunction. Intracerebroventricular infusion of a leptin receptor antagonist (SLA) in rats disrupts hypothalamic leptin signalling, leading to reduced signal transducer and activator of transcription 3 (STAT3) activation, decreased Socs3 and Pomc expression, and ...
Cristina Pintado, Lorena Mazuecos, Óscar Gómez‐Torres, Beatriz Merino, Elena Casanueva‐Álvarez, Blanca Rubio, Emma Burgos‐Ramos, Sara Artigas‐Jerónimo, Eduardo Moltó, Inés María Ramos, Justa María Poveda, Germán Perdomo, Irene Cózar‐Castellano, Carmen Arribas, Ernesto Bernal‐Mizrachi, Antonio Andrés, Nilda Gallardo   +16 more
wiley   +1 more source

A rare mutation in AgRP, +79G>A, affects promoter activity [PDF]

European Journal of Clinical Nutrition, 2006
The agouti-related protein is a powerful orexigenic peptide. A rare mutation, +79G>A, was identified in its minimal promoter in two white carriers. Comparison of the 45-year-old male proband, who was also a carrier of the common Ala67Thr polymorphism, with an age- and weight-matching wild-type population showed marginal differences for resting ...
Sozen, M. A., de Jonge, L. H. M., Greenway, F., Ravussin, E., Smith, S. R., Argyropoulos, G.   +5 more
openaire   +3 more sources

Neurobehavioural Genes Associated With Growth in Dusky Kob (Argyrosomus japonicus)

Animal Genetics, Volume 57, Issue 3, June 2026.
ABSTRACT Growth is a complex trait, influenced by numerous genes and environmental factors that transect various physiological pathways. This study sought to characterise the relationship between neurobehavioural development genes and growth in dusky kob juveniles.
J. E. Sampson, C. Rhode
wiley   +1 more source

Renewable Energy Use, Agricultural Productivity, and Economic Expansion Impact on Environmental Sustainability in India

Energy Science &Engineering, Volume 14, Issue 6, Page 2983-2995, June 2026.
ABSTRACT This research aims to explore the effects of agricultural productivity and the use of renewable energy sources on India's CO2 emissions while taking economic expansion into concern based on data during 1985–2022. This study applies the autoregressive distributed lag (ARDL) technique, dynamic‐ordinary least square (DOLS), fully‐modified ...
Palanisamy Manigandan, Radulescu Magdalena, Duraisamy Pachiyappan, Nadia Sha, Marian Cristescu   +4 more
wiley   +1 more source