Results 61 to 70 of about 17,109 (214)

Food intake regulation during pregnancy and lactation in mice with reduced activity of the melanocortin system

Вавиловский журнал генетики и селекции, 2016
Hypothalamic melanortin receptor (MCR) activation inhibits appetite. Neuropeptide Y (NPY) and Agouti Related Protein (AgRP) are coexpressed in some hypothalamic neurons and stimulate feeding, NPY via inhibition of MCR-expressing neurons, and AgRP via ...
E. N. Makarova, I. V. Romanova, N. M. Bazhan   +2 more
doaj   +1 more source

Gene expression analysis indicates CB1 receptor upregulation in the hippocampus and neurotoxic effects in the frontal cortex 3 weeks after single-dose MDMA administration in Dark Agouti rats. [PDF]

, 2013
BACKGROUND: 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") is a widely used recreational drug known to impair cognitive functions on the long-run.
A Alttoa, A Guellmar, A Subramanian, AC Parrott, AH Lichtman, AI Gulyas, AI Saeed, AI Saeed, AJ Bond, AM Lee, AO Mechan, AR Green, AR Green, AV Goonawardena, B Balogh, B den Hollander, BE Kosofsky, C Adori, C Adori, C Adori, C Bourgin, C Chayer, C Kay, CE Nulsen, CJ Gordon, Csaba Adori, D Merico, DD Han, DK Biezonski, E Kirilly, EA Kolbrich, ES Lein, Eszter Kirilly, FX Vollenweider, G Gerra, G Paxinos, GG Kovacs, Gyorgy Bagdy, H Honda, HS Mayberg, HW Broening, I Törk, J Duncan, J Karageorgiou, J Lazary, J Seniow, JA Lopez-Moreno, JE Malberg, JP Capela, JW Dalley, KG Baker, KK Murai, KV Savelieva, L Acsady, L Ferrington, Laszlo Tothfalusi, M Ashburner, M D’Esposito, M Hruska, MB Eisen, ME Greenberg, MI Colado, MJ Dunning, MN Hill, MS Cline, MT Herrero, N Easton, N Fernandez-Castillo, N Gyongyosi, N Gyongyosi, N Madronal, N Thiriet, P Andres, P Berghuis, P Shannon, Peter Petschner, PP Gao, R Core Team, R Edgar, R Gerlai, R Martinez-Turrillas, RA Stetler, RC Gentleman, RD Pearson, RE Hampson, RE Hampson, RJ Seitz, RL Buckner, Romeo D Ando, T Vitalis, UD McCann, UD McCann, Viola Tamasi, VK Mootha, Y Lu, Y Nawata   +95 more
core   +2 more sources

Effect of Social Rank on Gut Microbes and Their Metabolites of Greater Long‐Tailed Hamsters (Tscherskia triton)

Integrative Zoology, EarlyView.
Social rank in greater long‐tailed hamsters (Tscherskia triton) shapes gut microbiota composition and metabolite profiles. Dominant males exhibit a “high‐vigilance, metabolically activated” phenotype, with elevated aggression and specific gut microbiota enriched in energy‐harvesting taxa and fecal queuine.
Da Zhang, Xiaoming Xu, Zhibin Zhang
wiley   +1 more source

Amylin analogues as a novel perspective in anti‐obesity therapy

British Journal of Pharmacology, EarlyView.
Abstract Public health systems face a major challenge because of the worldwide obesity epidemic. The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively “lean” country, the numbers are alarmingly high and have reached almost 50% of the adult population.
Thomas A. Lutz
wiley   +1 more source

The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation [PDF]

, 2001
The ability to ensure continuous availability of energy despite highly variable supplies in the environment is a major determinant of the survival of all species.
Björntorp P., Choy L, Feinstein R, Francisco José Muruzábal, Fried SK, Gema Frühbeck, Greenberg AS, Grell M., Heaney ML, Janik JE, Javier Gómez-Ambrosi, Lafontan M, Lechan RM., Mantzoros CS, María Angela Burrell, Maslowska M, Mohamed-Ali V, Petruschke T, Rigden DJ, Saito T, Schmidt W, Serrero G, Sniderman AD, Spiegelman BM, Spiegelman BM, Stephens JM, Torres-Márquez ME, Wiman B, Zhang B, Zorad S   +29 more
core   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

mTORC1 Signaling in AgRP Neurons Is Not Required to Induce Major Neuroendocrine Adaptations to Food Restriction

Cells, 2023
Hypothalamic mTORC1 signaling is involved in nutrient sensing. Neurons that express the agouti-related protein (AgRP) are activated by food restriction and integrate interoceptive and exteroceptive signals to control food intake, energy expenditure, and ...
Gabriel O. de Souza, Pryscila D. S. Teixeira, Niels O. S. Câmara, Jose Donato   +3 more
doaj   +1 more source

Successful reprogramming of epiblast stem cells by blocking nuclear localization of β-catenin. [PDF]

, 2014
Epiblast stem cells (EpiSCs) in mice and rats are primed pluripotent stem cells (PSCs). They barely contribute to chimeric embryos when injected into blastocysts.
Hayama, Tomonari, Masaki, Hideki, Murayama, Hideyuki, Nakauchi, Hiromitsu, Sato, Hideyuki, Yamaguchi, Tomoyuki   +5 more
core   +2 more sources

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

An intrinsic gut leptin-melanocortin pathway modulates intestinal microsomal triglyceride transfer protein and lipid absorption

Journal of Lipid Research, 2010
Fat is delivered to tissues by apoB-containing lipoproteins synthesized in the liver and intestine with the help of an intracellular chaperone, microsomal triglyceride transfer protein (MTP).
Jahangir Iqbal, Xiaosong Li, Benny Hung-Junn Chang, Lawrence Chan, Gary J. Schwartz, Streamson C. Chua, Jr., M. Mahmood Hussain   +6 more
doaj   +1 more source