Results 71 to 80 of about 17,109 (214)

Astrocytes: New Targets of Melanocortin 4 Receptor Actions [PDF]

, 2013
Astrocytes exert a wide variety of functions with paramount importance in brain physiology. After injury or infection, astrocytes become reactive and they respond by producing a variety of inflammatory mediators that help maintain brain homeostasis. Loss
Carniglia, Lila, Caruso, Carla Mariana, Durand, Daniela Elizabeth, Lasaga, Mercedes Isabel, Scimonelli, Teresa Nieves   +4 more
core   +1 more source

Influence of MC1R Gene Variants on Coat Color of Indicine Cattle Breeds

Animal Genetics, Volume 57, Issue 3, June 2026.
ABSTRACT Indicine cattle display a broad range of coat colors, representing a relevant and breed‐defining trait required for registration in breeder association. Among the genes involved in pigmentation, MC1R stands out for modulating the synthesis of melanin‐related proteins and remains poorly explored in indicine cattle breeds. Therefore, we aimed to
Silel V. S. A. Maciel, Ingrid P. P. Oliveira, Beatriz B. Senes, Carolaine J. S. Santana, Jackeline S. Alves, Edilane A. da Silva, Fernando O. Franco, Bárbara C. F. da Silva, Fernando C. Cairo, Frederico C. Cairo, Aníbal E. Vercesi‐Filho, Raphael B. Costa, Gregório M. F. de Camargo   +12 more
wiley   +1 more source

Adiponectin potentiates the acute effects of leptin in arcuate Pomc neurons

Molecular Metabolism, 2016
Objective: Adiponectin receptors (AdipoRs) are located on neurons of the hypothalamus involved in metabolic regulation – including arcuate proopiomelanocortin (Pomc) and Neuropeptide Y/Agouti-related peptide (NPY/AgRP) neurons.
Jia Sun, Yong Gao, Ting Yao, Yiru Huang, Zhenyan He, Xingxing Kong, Kai-jiang Yu, Rui-tao Wang, Hongbo Guo, Jianqun Yan, Yongsheng Chang, Hong Chen, Philipp E. Scherer, Tiemin Liu, Kevin W. Williams   +14 more
doaj   +1 more source

Coat colours in the Massese sheep breed are associated with mutations in the agouti signalling protein (ASIP) and melanocortin 1 receptor (MC1R) genes [PDF]

, 2011
Massese is an Italian dairy sheep breed characterized by animals with black skin and horns and black or apparent grey hairs. Owing to the presence of these two coat colour types, this breed can be considered an interesting model to evaluate the effects
Beretti, F, Dall’Olio, S, Fontanesi, L, PORTOLANO, Baldassare, Russo, V.   +4 more
core   +1 more source

Factors Affecting Multiple Paternity: Insights From the Eastern Quoll (Dasyurus viverrinus)

Ecology and Evolution, Volume 16, Issue 5, May 2026.
Eastern quolls (Dasyurus viverrinus) exhibit multiple paternity in approximately half of all litters. Reproductive success is correlated with heavier weight, youth, and being black rather than fawn colour morph. A cross‐species analysis indicates that high rates of multiple paternity within the Dasyuridae area correlated with shorter lifespan and ...
Brittany M. Brockett, Linda E. Neaves, Maldwyn J. Evans, Iain J. Gordon, Jennifer C. Pierson, Belinda A. Wilson, Claire Wimpenny, Adrian D. Manning   +7 more
wiley   +1 more source

The Genetic Basis of Melanism in Abert’s Squirrel (Sciurus aberti)

Animals
Melanism is widespread in different taxa and has been hypothesized to provide adaptive benefits in certain environments. Melanism is typically caused by mutations in one of two regulatory genes: the Melanocortin 1 Receptor (MC1R) or the Agouti Signaling ...
Lake H. Barrett, Dean Fraga, Richard M. Lehtinen   +2 more
doaj   +1 more source

Direct modulation of GFAP-expressing glia in the arcuate nucleus bi-directionally regulates feeding

eLife, 2016
Multiple hypothalamic neuronal populations that regulate energy balance have been identified. Although hypothalamic glia exist in abundance and form intimate structural connections with neurons, their roles in energy homeostasis are less known.
Naiyan Chen, Hiroki Sugihara, Jinah Kim, Zhanyan Fu, Boaz Barak, Mriganka Sur, Guoping Feng, Weiping Han   +7 more
doaj   +1 more source

The role of hypothalamic endoplasmic reticulum stress in schizophrenia and antipsychotic-induced weight gain: A narrative review

Frontiers in Neuroscience, 2022
Schizophrenia (SCZ) is a serious mental illness that affects 1% of people worldwide. SCZ is associated with a higher risk of developing metabolic disorders such as obesity.
Ruqin Zhou, Meng He, Jun Fan, Ruoxi Li, Yufeng Zuo, Benben Li, Guanbin Gao, Taolei Sun   +7 more
doaj   +1 more source

The role of insulin receptor substrate 2 in hypothalamic and beta cell function [PDF]

, 2005
Insulin receptor substrate 2 (Irs2) plays complex roles in energy homeostasis. We generated mice lacking Irs2 in beta cells and a population of hypothalamic neurons (RIPCreIrs2KO), in all neurons (NesCreIrs2KO), and in proopiomelanocortin neurons ...
Al-Qassab, H, Ashford, MLJ, Barsh, GS, Batterham, RL, Bedford, DC, Bell, JD, Choudhury, AI, Claret, M, Clements, M, Diakonov, I, Heffron, H, Hisadome, K, MacColl, G, Moosajee, V, Selman, C, Simmgen, M, Smith, MA, Speakman, JR, Withers, DJ, Xu, AW   +19 more
core  

Adrenalectomy alters the sensitivity of the central nervous system melanocortin system [PDF]

, 2003
Removal of adrenal steroids by adrenalectomy (ADX) reduces food intake and body weight in rodents and prevents excessive weight gain in many genetic and dietary models of obesity. Thus, glucocorticoids appear to play a key role to promote positive energy
Clegg, DJ, Drazen, Deborah L., Drazen, DL, Schwartz, Michael W., Schwartz, MW, Seeley, Randy J., Seeley, RJ, van Dijk, G, Woods, SC, Woods, Stephen C., Wortman, Matthew D., Wortman, MD   +11 more
core   +2 more sources