Results 71 to 80 of about 959,384 (214)
Theagoutigene product stimulates pancreatic β-cell Ca2+signaling and insulin release
, 1999 Xue, B. Z., W. O. Wilkison, R. L. Mynatt, N. Moustaid, M. Goldman, and M. B. Zemel. The agouti gene product stimulates pancreatic β-cell Ca2+signaling and insulin release. Physiol.
W. O. WILKISON +5 more
core +1 more source
Adiponectin potentiates the acute effects of leptin in arcuate Pomc neurons
Molecular Metabolism, 2016 Objective: Adiponectin receptors (AdipoRs) are located on neurons of the hypothalamus involved in metabolic regulation – including arcuate proopiomelanocortin (Pomc) and Neuropeptide Y/Agouti-related peptide (NPY/AgRP) neurons.
Jia Sun +14 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor +4 more
wiley +1 more source
The Genetic Basis of Melanism in Abert’s Squirrel (Sciurus aberti)
AnimalsMelanism is widespread in different taxa and has been hypothesized to provide adaptive benefits in certain environments. Melanism is typically caused by mutations in one of two regulatory genes: the Melanocortin 1 Receptor (MC1R) or the Agouti Signaling ...
Lake H. Barrett +2 more
doaj +1 more source
Direct modulation of GFAP-expressing glia in the arcuate nucleus bi-directionally regulates feeding
eLife, 2016 Multiple hypothalamic neuronal populations that regulate energy balance have been identified. Although hypothalamic glia exist in abundance and form intimate structural connections with neurons, their roles in energy homeostasis are less known.
Naiyan Chen +7 more
doaj +1 more source
Frontiers in Neuroscience, 2022 Schizophrenia (SCZ) is a serious mental illness that affects 1% of people worldwide. SCZ is associated with a higher risk of developing metabolic disorders such as obesity.
Ruqin Zhou +7 more
doaj +1 more source
Ovarian hormones and high‐fat diet duration distinctively modulate hypothalamic chemokine profile
Journal of Neuroendocrinology, Volume 38, Issue 7, July 2026.Abstract Excessive intake of saturated fats triggers inflammation in the hypothalamus, a key regulator of energy balance. In the chronic phase of this inflammatory response, bone marrow‐derived and lymphoid cells are chemoattracted to this region, partially mitigating high‐fat diet (HFD)‐induced metabolic impairments.
Alexia Guimaraes Batista Augusto +8 more
wiley +1 more source
Influence of MC1R Gene Variants on Coat Color of Indicine Cattle Breeds
Animal Genetics, Volume 57, Issue 3, June 2026.ABSTRACT Indicine cattle display a broad range of coat colors, representing a relevant and breed‐defining trait required for registration in breeder association. Among the genes involved in pigmentation, MC1R stands out for modulating the synthesis of melanin‐related proteins and remains poorly explored in indicine cattle breeds. Therefore, we aimed to
Silel V. S. A. Maciel +12 more
wiley +1 more source
Neurobehavioural Genes Associated With Growth in Dusky Kob (Argyrosomus japonicus)
Animal Genetics, Volume 57, Issue 3, June 2026.ABSTRACT Growth is a complex trait, influenced by numerous genes and environmental factors that transect various physiological pathways. This study sought to characterise the relationship between neurobehavioural development genes and growth in dusky kob juveniles.
J. E. Sampson, C. Rhode
wiley +1 more source
Agouti regulates adipocyte transcription factors
, 2001 Agouti is a secreted paracrine factor that regulates pigmentation in hair follicle melanocytes. Several dominant mutations cause ectopic expression of agouti, resulting in a phenotype characterized by yellow fur, adult-onset obesity and diabetes ...
Randall L. Mynatt +1 more
core +1 more source