Results 91 to 100 of about 17,109 (214)
Journal of Investigative Dermatology, 1997 In mouse follicular melanocytes, the switch between eumelanin and pheomelanin synthesis is regulated by the extension locus, which encodes the melanocortin-1 receptor (MC1R) and the agouti locus, which encodes a novel paracrine-signaling molecule that inhibits binding of melanocortins to the MC1R.
Suzuki, Itaru +8 more
openaire +2 more sources
Associations of MC1R Substitutions With Body Color Variation in a Desert Lizard
Ecology and Evolution, Volume 16, Issue 4, April 2026.We successfully identified two amino acid substitutions (V165I and V237I) in MC1R that are significantly associated with body color variation between melanistic and non‐melanistic populations of a toad‐headed lizard, P. versicolor. In silico analysis revealed that both substitutions located in transmembrane (TM) domains affect the binding affinity ...
Haojie Tong +6 more
wiley +1 more source
CNS Control of Glucose Metabolism: Response to Environmental Challenges [PDF]
, 2013 Over the last 15 years, considerable work has accumulated to support the role of the CNS in regulating postprandial glucose levels. As discussed in the first section of this review, the CNS receives and integrates information from afferent neurons ...
Arble, Deanna M., Sandoval, Darleen A.
core +1 more source
Time‐Restricted Feeding Alters Behavior in a Sex‐Specific Manner in Mice With Neuropathic Pain
Molecular Nutrition &Food Research, Volume 70, Issue 8, 27 April 2026.Time‐restricted feeding (TRF) alleviates anxiety‐like behavior in male mice with neuropathic pain (NP), but not in females. Upon nerve injury, TRF altered the diurnal expression of transcripts in the hypothalamus. These findings suggest that TRF should be explored as a new therapeutic approach to alleviate the comorbid anxiety in NP.
Manqing Wen +3 more
wiley +1 more source
Nuclear genes involved in mitochondria-to-nucleus communication in breast cancer cells
Molecular Cancer, 2002 Background The interaction of nuclear and mitochondrial genes is an essential feature in maintenance of normal cellular function. Of 82 structural subunits that make up the oxidative phosphorylation system in the mitochondria, mitochondrial DNA (mtDNA ...
Gabrielson Edward +4 more
doaj +1 more source
Signature of balancing selection at the MC1R gene in Kunming dog populations. [PDF]
PLoS ONE, 2013 Coat color in dog breeds is an excellent character for revealing the power of artificial selection, as it is extremely diverse and likely the result of recent domestication.
Guo-dong Wang +6 more
doaj +1 more source
Appropriate Inhibition of Orexigenic Hypothalamic Arcuate Nucleus Neurons Independently of Leptin Receptor/STAT3 Signaling [PDF]
, 2007 Leptin directly suppresses the activity of orexigenic neurons in the hypothalamic arcuate nucleus (ARC). We examined c-Fos-like immunoreactivity (CFLIR) as a marker of ARC neuronal activity in db/db mice devoid of the signaling form of the leptin ...
Bates, Sarah H. +10 more
core +2 more sources
Epigenetics—Innovations and Misconceptions
Natural Sciences, Volume 6, Issue 2, April 2026.ABSTRACT Epigenetics is a scientific field whose definition has changed over time. Established in the 1940s by C.H. Waddington by synthesis from embryology and genetics, the term “epigenetics” is now mainly used to describe the role of chromatin modifications in the regulation and perpetuation of gene activity states.
Bernhard Horsthemke
wiley +1 more source
Sympathetic Neurotransmitters Modulate Osteoclastogenesis and Osteoclast Activity in the Context of Collagen-Induced Arthritis. [PDF]
PLoS ONE, 2015 Excessive synovial osteoclastogenesis is a hallmark of rheumatoid arthritis (RA). Concomitantly, local synovial changes comprise neuronal components of the peripheral sympathetic nervous system.
Dominique Muschter +4 more
doaj +1 more source
Transient early food restriction leads to hypothalamic changes in the long‐lived crowded litter female mice [PDF]
, 2015 Transient nutrient restriction in the 3 weeks between birth and weaning (producing “crowded litter” or CL mice) leads to a significant increase in lifespan and is associated with permanent changes in energy homeostasis, leptin, and insulin sensitivity ...
Bartke, Andrzej +5 more
core +1 more source