Results 91 to 100 of about 959,384 (214)

The Yellow Agouti Mutation Alters Some But Not All Responses to Diet and Exercise [PDF]

, 2004
OBJECTIVE: Effects of ectopic expression of the agouti signaling protein were studied on responses to diet restriction and exercise in C57BL/6J (B6) mice and obese B6 mice congenic for the yellow agouti mutation [B6.Cg-Ay (Ay)].
Warden, Craig H, Fisler, Janis S, Espinal, Glenda M, Havel, Peter J, Chiu, Sally, Stern, Judith S   +5 more
core   +1 more source

Sympathetic Neurotransmitters Modulate Osteoclastogenesis and Osteoclast Activity in the Context of Collagen-Induced Arthritis. [PDF]

PLoS ONE, 2015
Excessive synovial osteoclastogenesis is a hallmark of rheumatoid arthritis (RA). Concomitantly, local synovial changes comprise neuronal components of the peripheral sympathetic nervous system.
Dominique Muschter, Nicole Schäfer, Hubert Stangl, Rainer H Straub, Susanne Grässel   +4 more
doaj   +1 more source

Integrative Advances in Equine Genomics From Reference Assemblies to Evolutionary History and Key Traits

Evolutionary Applications, Volume 19, Issue 6, June 2026.
ABSTRACT Horses are major domestic animals and cultural symbols that have accompanied humans for millennia. They underpin transport, agriculture, warfare and sport, and also provide a model for studying domestication, complex traits and adaptive evolution.
Ying Lu, Ruoshan Ma, Bo Wang, Jiao Wu, Yuqing Chong, Zhendong Gao, Weidong Deng   +6 more
wiley   +1 more source

The alpaca agouti gene: Genomic locus, transcripts and causative mutations of eumelanic and pheomelanic coat color [PDF]

, 2013
The agouti gene encodes the agouti signaling protein (ASIP) which regulates pheomelanin and eumelanin synthesis in mammals. To investigate the role of agouti in coat color variation of alpaca, we characterized the agouti gene and identified three ...
LA TERZA, Antonietta, BATHRACHALAM, CHANDRAMOHAN, LA MANNA, Vincenzo, RENIERI, Carlo   +3 more
core   +1 more source

The NF‐κB Signalling Pathway: Mechanisms, Consequences and Therapeutic Targets

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Nuclear Factor‐kappa B (NF‐κB) is a master transcriptional regulator orchestrating critical cellular processes, predominantly immunity and inflammation. However, its aberrant constitutive activation has emerged as a unifying pathogenetic hallmark across diverse malignancies, autoimmune disorders, and chronic inflammatory diseases.
Bherouz Pourdad, Arash Pourdad
wiley   +1 more source

Altered responses to ghrelin and food cues in AgRP neurons during pregnancy and lactation

Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.
Abstract Pregnancy and lactation trigger many metabolic adaptations, including increased food intake to support the energy demands of the growing foetus and then to provide nutrition through milk production after birth. Ghrelin, an orexigenic hormone, activates agouti related peptide (AgRP) neurons in the arcuate nucleus to promote food intake.
C. L. Murrell, M. R. Perkinson, Z. B. Andrews, D. R. Grattan, S. R. Ladyman   +4 more
wiley   +1 more source

Opioidergic signaling contributes to food-mediated suppression of AgRP neurons

Cell Reports
Summary: Opioids are generally known to promote hedonic food consumption. Although much of the existing evidence is primarily based on studies of the mesolimbic pathway, endogenous opioids and their receptors are widely expressed in hypothalamic appetite
Nilufer Sayar-Atasoy, Yavuz Yavuz, Connor Laule, Chunyang Dong, Hyojin Kim, Jacob Rysted, Kyle Flippo, Debbie Davis, Iltan Aklan, Bayram Yilmaz, Lin Tian, Deniz Atasoy   +11 more
doaj   +1 more source

Impact of hypothalamic reactive oxygen species in the control of energy metabolism and food intake

Frontiers in Neuroscience, 2015
Hypothalamus is a key area involved in the control of metabolism and food intake via the integrations of numerous signals (hormones, neurotransmitters, metabolites) from various origins.
Anne eDrougard, Audren eFournel, Philippe eValet, Claude eKnauf   +3 more
doaj   +1 more source

KNDy kisspeptin is required for metabolic homeostasis in female mice in an ovarian hormone‐independent manner

Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.
Abstract Disorders of gonadotropin pulsatility contribute to reproductive dysfunction in humans and are often associated with metabolic dysfunction. Hypogonadotropic hypogonadism is characterized by chronically insufficient gonadotropin hormone production, leading to reproductive and metabolic impairments, such as infertility and obesity.
Nimisha Nandankar, Ariel L. Negrón, Harshini Ganesh, Natalia Youssef, Saad Farooq, Sarmed Al‐Samerria, Jon E. Levine, Sally Radovick   +7 more
wiley   +1 more source

Bone morphogenetic protein (BMP) signaling controls hair pigmentation by means of cross-talk with the melanocortin receptor-1 pathway

, 2005
NoHair pigmentation is controlled by tightly coordinated programs of melanin synthesis and involves signaling through the melanocortin type 1 receptor (MC-1R) that regulates the switch between pheomelanogenesis and eumelanogenesis.
Brissette, Janice L, Fessing, Michael Y., Sharova, T.Y., Brissette, J.L., Botchkarev, Vladimir A., Haskell-Luevano, Carrie, Funa, Keiko,, Weiner, L., Fessing, Michael, Gilchrest, B.A., Botchkarev, Vladimir A, Weiner, Lorin, Sharova, Tatyana Y, Funa, K., Sharov, Andrey A, Haskell-Luevano, C., Sharov, A.A., Atoyan, R., Atoyan, Ruzanna, Gilchrest, Barbara A   +19 more
core   +1 more source