Results 101 to 110 of about 17,109 (214)

Signal Amplification in the HPT Axis—Evidence for Its Existence, Location, Significance, and Molecular Mechanisms

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Thyroid hormones (THs) are under negative feedback regulation via the hypothalamic–pituitary‐thyroid (HPT) axis. How this axis operates to keep the circulating THs within a narrow physiological range is not well understood quantitatively. Led by the design principle of robust homeostatic feedback control, here we review and synthesize the ...
Li Jing, Sarahna A. Moyd, Qiang Zhang
wiley   +1 more source

Feeding Stimulates Sphingosine-1-Phosphate Mobilization in Mouse Hypothalamus. [PDF]

, 2019
Previous studies have shown that the sphingolipid-derived mediator sphingosine-1-phosphate (S1P) reduces food intake by activating G protein-coupled S1P receptor-1 (S1PR1) in the hypothalamus.
Misto, Alessandra, Piomelli, Daniele, Realini, Natalia, Vozella, Valentina   +3 more
core   +1 more source

Identification of a new Corin atrial natriuretic peptide-converting enzyme substrate: Agouti-signaling protein (ASIP)

, 2023
AbstractCorin is a transmembrane tethered enzyme best known for processing the hormone atrial natriuretic peptide (ANP) in cardiomyocytes to control electrolyte balance and blood pressure. Loss of function mutations in Corin prevent ANP processing and lead to hypertension.
Bryan T. MacDonald, Nadine H. Elowe, Colin W. Garvie, Virendar K. Kaushik, Patrick T. Ellinor   +4 more
openaire   +2 more sources

Obesity and Metabolic Dysfunction‐Associated Steatotic Liver Disease (MASLD): A Literature Review on Pathophysiology and Treatment

Diabetes, Obesity and Metabolism, Volume 28, Issue S2, Page 19-30, April 2026.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) represents a key hepatic manifestation of obesity and systemic metabolic dysfunction and is a leading cause of chronic liver disease worldwide. Obesity‐driven mechanisms, including adipose tissue dysfunction, insulin resistance and increased free fatty acid flux to the liver ...
Michael Romanos, Juan M. Garcia Cordova, Jose Villamarin, Juan D. Pazmino Zurita, Andres Acosta   +4 more
wiley   +1 more source

Noradrenergic inhibition of definitive POMC neurons through direct and indirect mechanisms

Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Norepinephrine and the α2‐adrenoceptor agonist UK 14,304 robustly inhibit definitive arcuate POMC neurons. Direct inhibition is mediated by ADRA2A‐dependent activation of potassium conductances, while additional indirect mechanisms also contribute. In vivo, inducible POMC‐specific Adra2a deletion minimally affects energy balance and modestly impairs ...
Olivier Lavoie, Audrey Turmel, Axelle Khouma, Moein Minbashi Moeini, Chen Liu, Natalie J. Michael, Alexandre Caron   +6 more
wiley   +1 more source

Opioidergic signaling contributes to food-mediated suppression of AgRP neurons

Cell Reports
Summary: Opioids are generally known to promote hedonic food consumption. Although much of the existing evidence is primarily based on studies of the mesolimbic pathway, endogenous opioids and their receptors are widely expressed in hypothalamic appetite
Nilufer Sayar-Atasoy, Yavuz Yavuz, Connor Laule, Chunyang Dong, Hyojin Kim, Jacob Rysted, Kyle Flippo, Debbie Davis, Iltan Aklan, Bayram Yilmaz, Lin Tian, Deniz Atasoy   +11 more
doaj   +1 more source

Impact of hypothalamic reactive oxygen species in the control of energy metabolism and food intake

Frontiers in Neuroscience, 2015
Hypothalamus is a key area involved in the control of metabolism and food intake via the integrations of numerous signals (hormones, neurotransmitters, metabolites) from various origins.
Anne eDrougard, Audren eFournel, Philippe eValet, Claude eKnauf   +3 more
doaj   +1 more source

GABA receptor modulation of arcuate kisspeptin neuron bursting and synchronization activity in female mice

Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Abstract The arcuate nucleus kisspeptin (ARNKISS) neurons intermittently synchronize their activity to operate as the GnRH pulse generator and drive pulsatile reproductive hormone secretion in mammals. Although ARNKISS neurons are known to receive various GABAergic inputs, the effects of GABAA and GABAB receptor modulation on their ability to ...
Toby Eddleston, Paul G. Morris, Allan E. Herbison   +2 more
wiley   +1 more source

The role of agomelatine in appetite regulation and body weight in rats

Experimental Physiology, Volume 111, Issue 4, Page 1808-1818, 1 April 2026.
Abstract The hypothalamic nuclei play a central role in the synthesis of anorexigenic and orexigenic neuropeptides, which are regulated by peripheral hormones, like leptin and ghrelin. Melatonergic receptors (MT1/MT2) are prominently expressed in the arcuate nucleus of the hypothalamus – an essential hub for appetite control – and in peripheral ...
Engin Korkmaz, Yavuz Erden, Çiğdem Tekin, Suat Tekin   +3 more
wiley   +1 more source

Development of a genetically encoded melanocortin sensor for high sensitivity in vivo imaging

Molecular Metabolism
Objective: The central melanocortin system, composed of peptides derived from pro-opiomelanocortin (POMC) such as the melanocyte-stimulating hormones (α-, β-, γ-MSH) and melanocortin 4 receptors (MC4R), along with the agouti-related protein (AgRP), plays
Yoon Namkung, Tal Slutzki, Joao Pedroso, Xiaohong Liu, Paul V. Sabatini, Maia V. Kokoeva, Stéphane A. Laporte   +6 more
doaj   +1 more source