Results 81 to 90 of about 959,384 (214)

Cell type-specific transcriptomics of hypothalamic energy-sensing neuron responses to weight-loss

eLife, 2015
Molecular and cellular processes in neurons are critical for sensing and responding to energy deficit states, such as during weight-loss. Agouti related protein (AGRP)-expressing neurons are a key hypothalamic population that is activated during energy ...
Fredrick E Henry, Ken Sugino, Adam Tozer, Tiago Branco, Scott M Sternson   +4 more
doaj   +1 more source

Agouti revisited: transcript quantification of the ASIP gene in bovine tissues related to protein expression and localization. [PDF]

PLoS ONE, 2012
Beside its role in melanogenesis, the agouti signaling protein (ASIP) has been related to obesity. The potentially crucial role in adipocyte development makes it a tempting candidate for economic relevant, fat related traits in farm animals.
Elke Albrecht, Katrin Komolka, Judith Kuzinski, Steffen Maak   +3 more
doaj   +1 more source

The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system

, 2008
INTRODUCTION: Ghrelin and cannabinoids stimulate appetite, this effect possibly being mediated by the activation of hypothalamic AMP-activated protein kinase (AMPK), a key enzyme in appetite and metabolism regulation. The cannabinoid receptor type 1 (CB1)
Judith Harvey-White, Francesca Lolli, Farkas, I., Amin, F., Mirjam Christ-Crain, Kola, Blerina, Fekete, Csaba, George Kunos, Kola, B., Faisal Amin, A. B. Grossman, M. Korbonits, Blerina Kola, Liposits, Zsolt, G. Kunos, Ashley B Grossman, B. Kola, Amin, F, Gábor Wittmann, Kunos, George, Christ-Crain, M, Farkas, Imre, Lolli, F, Zsolt Liposits, Lolli, F., F. Amin, Farkas, I, Christ-Crain, M., Korbonits, M., I. Farkas, Grossman, AB, C. Fekete, Kola, B, Harvey-White, J., Wittmann, Gábor, Korbonits, Márta, G. Wittmann, Harvey-White, J, Fekete, C, Harvey-White, Judith, Márta Korbonits, Imre Farkas, Liposits, Z, Z. Liposits, Grossman, Ashley B., Ashley B. Grossman, Wittmann, G., Christ-Crain, Mirjam, Amin, Faisal, Lolli, Francesca, Liposits, Z., M. Christ Crain, J. Harvey White, Fekete, C., Korbonits, M, Kunos, G., Csaba Fekete, Grossman, A. B., Kunos, G, Wittmann, G   +59 more
core   +1 more source

ASIP Variants in Livestock: It's Not Black and White

Animal Genetics, Volume 57, Issue 3, June 2026.
ABSTRACT Fur and feather pigmentation play an important role in the survival and reproduction of many species, as well as in selective breeding and agriculture. The synthesis of pigment molecules, eumelanin and pheomelanin, is partially regulated by the agouti signalling protein (ASIP) encoded by the ASIP gene.
Isabella M. Brown, Kylie A. Munyard
wiley   +1 more source

Hydroxy‐α‐Sanshools From Zanthoxylum bungeanum Maxim. Alleviate Obesity in Mice via the Regulation of Appetite and Gut Microbiota

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Hydroxy‐alpha‐sanshool could modulate the expression of appetite‐related factors and the composition of intestinal microbiota in mice fed with a high‐fat diet by regulating food intake and maintaining energy homeostasis, which is consistent with the involvement of the gut‐brain axis in this regulatory mechanism.
Tianting Luo, Yuping Zhu, Fangyan Xu, Jiao Xie, Huifang Chen, Likang Qin, Tingyuan Ren   +6 more
wiley   +1 more source

Cilia in Nervous System Development, Function, and Disease

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Cilia are evolutionarily conserved organelles that function as essential sensory and motility platforms in the nervous system. This review outlines key cilia‐dependent signaling pathways and their roles in neural development and function. Furthermore, it highlights how ciliary dysfunction can lead to a variety of neurological disorders, known as ...
Qingchao Li, Anqi Zhang, Ting Song
wiley   +1 more source

Nuclear genes involved in mitochondria-to-nucleus communication in breast cancer cells

Molecular Cancer, 2002
Background The interaction of nuclear and mitochondrial genes is an essential feature in maintenance of normal cellular function. Of 82 structural subunits that make up the oxidative phosphorylation system in the mitochondria, mitochondrial DNA (mtDNA ...
Gabrielson Edward, Anbazhagan Ramaswamy, Kachhap Sushant, Delsite Robert, Singh Keshav K   +4 more
doaj   +1 more source

Signature of balancing selection at the MC1R gene in Kunming dog populations. [PDF]

PLoS ONE, 2013
Coat color in dog breeds is an excellent character for revealing the power of artificial selection, as it is extremely diverse and likely the result of recent domestication.
Guo-dong Wang, Lu-guang Cheng, Ruo-xi Fan, David M Irwin, Shu-sheng Tang, Jian-guo Peng, Ya-ping Zhang   +6 more
doaj   +1 more source

Mutations in the melanocortin 1 receptor, β-defensin103 and agouti signaling protein genes, and their association with coat color phenotypes in Akita-inu dogs.

Journal of Veterinary Medical Science, 2011
To identify factors that control coat color in Akita-inu dogs, we sequenced all the exons of the melanocortin 1 receptor (MC1R), β-defensin103 (CBD103) and agouti signaling protein (ASIP) genes of dogs with four distinct coat colors, namely, brindle ...
Mieko Oguro-Okano, M. Honda, K. Yamazaki, K. Okano   +3 more
semanticscholar   +1 more source

G Protein‐Coupled Receptor 17 (Gpr17) Enhances Leptin and Insulin Sensitivity in Lean and Obese Mouse Models

Obesity, Volume 34, Issue S1, Page 77-87, June 2026.
This study identifies G protein‐coupled receptor 17 (Gpr17) as a novel regulator of leptin and insulin sensitivity. Using complementary knockout models, we demonstrate that Gpr17 deletion enhances energy expenditure, restores leptin responsiveness, and improves insulin sensitivity, revealing Gpr17 as a potential therapeutic GPCR target for obesity and ...
Xun Sun, Connor Mahler, Natalie D. Stull, Ali Nasiri, Baohua Zhou, Varman Samuel, Gerald Shulman, Jonathan N. Flak, Hongxia Ren   +8 more
wiley   +1 more source