Results 41 to 50 of about 17,109 (214)

Novel hypophysiotropic AgRP2 neurons and pineal cells revealed by BAC transgenesis in zebrafish [PDF]

, 2017
The neuropeptide agouti-related protein (AgRP) is expressed in the arcuate nucleus of the mammalian hypothalamus and plays a key role in regulating food consumption and energy homeostasis.
Buchshtab, A, Cone, RD, Gothilf, Y, Hawkins, TA, Shainer, I, Wilson, SW   +5 more
core   +1 more source

Standardization of Methodology for Polymorphism Detection in ASIP, MC1R and MATP Genes in Relation to Colour in Horses

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2017
The basic colour in horses, such as black, brown and chestnut is affected by only two genes MC1R and ASIP. Other colours in horses are affected by modifying genes, such as dilution gene MATP.
Eliška Horecká, Čeněk Horecký, Aleš Knoll   +2 more
doaj   +1 more source

Hypothalamic GHR—SIRT1 Axis in Fasting

Cells, 2021
Many aspects of physiological functions are controlled by the hypothalamus, a brain region that connects the neuroendocrine system to whole-body metabolism.
Juliana Bezerra Medeiros de Lima, Chidera Ubah, Lucas Kniess Debarba, Iven Ayyar, Olesya Didyuk, Marianna Sadagurski   +5 more
doaj   +1 more source

Hedgehog Pathway Activation Alters Ciliary Signaling in Primary Hypothalamic Cultures [PDF]

, 2019
Primary cilia dysfunction has been associated with hyperphagia and obesity in both ciliopathy patients and mouse models of cilia perturbation. Neurons throughout the brain possess these solitary cellular appendages, including in the feeding centers of ...
Antonellis, Patrick J., Bansal, Ruchi, Baucum, Anthony J., Berbari, Nicolas F., Cummins, Theodore R., Engle, Staci E., Reiter, Jeremy F., Whitehouse, Logan S.   +7 more
core   +1 more source

Melanocortin receptor accessory proteins in adrenal disease and obesity. [PDF]

, 2015
Melanocortin receptor accessory proteins (MRAPs) are regulators of the melanocortin receptor family. MRAP is an essential accessory factor for the functional expression of the MC2R/ACTH receptor.
Adrian J. Clark, Agulleiro, Asai, Balthasar, Beaumont, Beaumont, Begriche, Begriche, Berglund, Bouw, Breit, Catania, Chai, Chambers, Chan, Chen, Chen, Chida, Chung, Clark, Clark, Cone, Cooray, David S. Jackson, Dores, Elias, Farooqi, Gardiner, Getting, Gorrigan, Griffon, He, Hinkle, Hofland, Hu, Hughes, Huszar, Kay, Kay, Kiefer, Kim, Lee, Leoni, Li F. Chan, Lim, Liu, Loos, Lu, MacNeil, Mencarelli, Metherell, Mo, Moller, Montero-Melendez, Nijenhuis, Noon, O'Shaughnessy, Ollmann, Panaro, Park, Pritchard, Rodrigues, Roy, Roy, Rumie, Sebag, Sebag, Sebag, Sebag, Shutter, Shwetha Ramachandrappa, Smith, Sohn, Star, Sutton, Sutton, Sutton, Swope, Tontonoz, Vage, Vaisse, van der Kraan, van der Ploeg, Vinson, Webb, Xu, Yang, Yeo, Zhong   +88 more
core   +2 more sources

Reply to Braasch and Postlethwait: Evolutionary origin of the teleost A2 agouti genes ( agouti signaling protein 2 and agouti-related protein 2 ) remains unclear [PDF]

Proceedings of the National Academy of Sciences, 2011
Tetrapods express one agouti gene [agouti signaling protein (asip)] in the skin regulating pigmentation and a second [agouti-related protein (agrp)] in the brain regulating energy homeostasis. In contrast, most teleosts have four genes encoding agouti-type proteins.
Helgi B. Schiöth, Åke Västermark, Roger D. Cone   +2 more
openaire   +1 more source

Facing the Challenges of Neuropeptide Gene Knockouts: Why Do They Not Inhibit Reproduction in Adult Teleost Fish?

Frontiers in Neuroscience, 2018
Genetic manipulation of teleost endocrine systems started with transgenic overexpression of pituitary growth hormone. Such strategies enhance growth and reduce fertility, but the fish still breed.
Vance L. Trudeau
doaj   +1 more source

Obesity Induces Hypothalamic Endoplasmic Reticulum Stress and Impairs Proopiomelanocortin (POMC) Post-translational Processing [PDF]

, 2013
It was shown previously that abnormal prohormone processing or inactive proconverting enzymes that are responsible for this processing cause profound obesity.
Cakir, Isin, Cyr, Nicole E., Litvinov, Bogdan Patedakis, Nillni, Eduardo A., Perello, Mario, Romero, Amparo, Stuart, Ronald C.   +6 more
core   +1 more source

New insights in the pathogenesis of alcohol-related liver disease: The metabolic, immunologic, and neurologic pathways☆

Liver Research, 2023
Alcohol-related liver disease (ALD) became an important health issue worldwide. Following chronic alcohol consumption, the development of ALD might be caused by metabolic and immunologic factors, such as reactive oxygen species (ROS) and pro-inflammatory
Tom Ryu, Kyurae Kim, Sung Eun Choi, Katherine Po Sin Chung, Won-Il Jeong   +4 more
doaj   +1 more source

Detecting epistasis via Markov bases [PDF]

, 2010
Rapid research progress in genotyping techniques have allowed large genome-wide association studies. Existing methods often focus on determining associations between single loci and a specific phenotype.
Malaspinas, Anna-Sapfo, Uhler, Caroline
core   +1 more source