Structure-Activity Relationship Studies on a Macrocyclic Agouti-Related Protein (AGRP) Scaffold Reveal Agouti Signaling Protein (ASP) Residue Substitutions Maintain Melanocortin-4 Receptor Antagonist Potency and Result in Inverse Agonist Pharmacology at the Melanocortin-5 Receptor. [PDF]
J Med Chem, 2017 Ericson MD +4 more
europepmc +2 more sources
Integration of Nutrient Sensing in Fish Hypothalamus
Frontiers in Neuroscience, 2021 The knowledge regarding hypothalamic integration of metabolic and endocrine signaling resulting in regulation of food intake is scarce in fish. Available studies pointed to a network in which the activation of the nutrient-sensing (glucose, fatty acid ...
José L. Soengas
doaj +1 more source
Role of the Melanocortin System in Gonadal Steroidogenesis of Zebrafish
Animals, 2022 In teleost, as in other vertebrates, stress affects reproduction. A key component of the stress response is the pituitary secretion of the adrenocorticotropic hormone (ACTH), which binds to the melanocortin 2 receptor (MC2R) in the adrenal glands and ...
Sandra Navarro +6 more
doaj +1 more source
bioRxiv, 2023 Corin is a transmembrane tethered enzyme best known for processing the hormone atrial natriuretic peptide (ANP) in cardiomyocytes to control electrolyte balance and blood pressure.
Bryan T. MacDonald +4 more
semanticscholar +1 more source
Livestock Science, 2021 The agouti signaling protein (ASIP) gene has a crucial role in pigmentation by encoding a protein that binds the melanocortin 1 receptor and stimulates the synthesis of pheomelanin rather than eumelanin.
D. Guan +6 more
semanticscholar +1 more source
The Journal of Poultry Science, 2022 Previous studies in mammalian obesity models have suggested that central transforming growth factor-β (TGF-β) controls the gene expression of appetite-regulating neuropeptides and peripheral energy metabolism.
Takaoki Saneyasu +5 more
doaj +1 more source
Melanism in peromyscus is caused by independent mutations in agouti. [PDF]
PLoS ONE, 2009 Identifying the molecular basis of phenotypes that have evolved independently can provide insight into the ways genetic and developmental constraints influence the maintenance of phenotypic diversity.
Evan P Kingsley +3 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2011 Helgi B Schioth +2 more
exaly +2 more sources
Coat colour phenotype of Qingyu pig is associated with polymorphisms of melanocortin receptor 1 gene [PDF]
Asian-Australasian Journal of Animal Sciences, 2017 Objective Qingyu pig, a Chinese indigenous pig breed, exhibits two types of coat colour phenotypes, including pure black and white with black spotting respectively.
Xiaoqian Wu +11 more
doaj +1 more source
Effect of 24 h Fasting on Gene Expression of AMPK, Appetite Regulation Peptides and Lipometabolism Related Factors in the Hypothalamus of Broiler Chicks [PDF]
Asian-Australasian Journal of Animal Sciences, 2012 The 5’-adenosine monophosphate-activated protein kinase (AMPK) is a key part of a kinase-signaling cascade that acts to maintain energy homeostasis. The objective of this experiment was to investigate the possible effects of fasting and refeeding on the ...
Liu Lei, Zhu Lixian
doaj +1 more source