Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity. [PDF]
Nat Metab, 2022 Abstract Here we report a heterozygous tandem duplication at the ASIP (agouti signaling protein) gene locus causing ubiquitous, ectopic ASIP expression in a female patient with extreme childhood obesity. The mutation places
Kempf E +17 more
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Atypical Genotypes for Canine Agouti Signaling Protein Suggest Novel Chromosomal Rearrangement. [PDF]
Genes (Basel), 2020 Canine coat color is a readily observed phenotype of great interest to dog enthusiasts; it is also an excellent avenue to explore the mechanisms of genetics and inheritance. As such, multiple commercial testing laboratories include basic color alleles in their popular screening panels, allowing for the creation of genotyped datasets at a scale not ...
Dreger DL +6 more
europepmc +4 more sources
An Agouti-Signaling-Protein Mutation is Strongly Associated with Melanism in European Roe Deer (Capreolus capreolus). [PDF]
Genes (Basel), 2020 Although the European roe deer (Capreolus capreolus) population of North-West Germany has a remarkable number of melanistic specimens between 10% and 25%, the underlying genetic mutation-causing melanism is still unknown. We used a gene targeting approach focusing on MC1R and ASIP as important genes of coat coloration. Overall, 1384 bp of MC1R and 2039
Reissmann M +4 more
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Agouti-Signalling Protein Overexpression Reduces Aggressiveness in Zebrafish
Biology, 2023 Feeding motivation plays a crucial role in food intake and growth. It closely depends on hunger and satiation, which are controlled by the melanocortin system. Overexpression of the inverse agonist agouti-signalling protein (ASIP) and agouti-related protein (AGRP) leads to enhanced food intake, linear growth, and weight. In zebrafish, overexpression of
Ana Rocha +3 more
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Effects of Recombinant Agouti-Signaling Protein on Melanocortin Action [PDF]
Molecular Endocrinology, 1997 Mouse agouti protein is a paracrine signaling molecule that has previously been demonstrated to be an antagonist of melanocortin action at several cloned rodent and human melanocortin receptors. In this study we report the effects of agouti-signaling protein (ASIP), the human homolog of mouse agouti, on the action of alpha-MSH or ACTH at the five known
Y K, Yang +6 more
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Modulation of murine melanocyte function in vitro by agouti signal protein [PDF]
The EMBO Journal, 1997 Molecular and biochemical mechanisms that switch melanocytes between the production of eumelanin or pheomelanin involve the opposing action of two intercellular signaling molecules, alpha-melanocyte-stimulating hormone (MSH) and agouti signal protein (ASP).
C, Sakai +8 more
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A Polymorphism in the Agouti Signaling Protein Gene Is Associated with Human Pigmentation [PDF]
The American Journal of Human Genetics, 2002 In mice and humans, binding of alpha-melanocyte--stimulating hormone to the melanocyte-stimulating--hormone receptor (MSHR), the protein product of melanocortin-1 receptor (MC1R) gene, leads to the synthesis of eumelanin. In the mouse, ligation of MSHR by agouti signaling protein (ASP) results in the production of pheomelanin. The role of ASP in humans
Kanetsky, Peter A. +5 more
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Effect of 24 h Fasting on Gene Expression of AMPK, Appetite Regulation Peptides and Lipometabolism Related Factors in the Hypothalamus of Broiler Chicks [PDF]
Asian-Australasian Journal of Animal Sciences, 2012 The 5’-adenosine monophosphate-activated protein kinase (AMPK) is a key part of a kinase-signaling cascade that acts to maintain energy homeostasis. The objective of this experiment was to investigate the possible effects of fasting and refeeding on the ...
Liu Lei, Zhu Lixian
doaj +1 more source
Physiological and Anatomical Circuitry between Agouti-Related Protein and Leptin Signaling* [PDF]
Endocrinology, 1999 Agouti-related protein (AGRP) is an orexigenic neuropeptide that acts via central melanocortin receptors, and whose messenger RNA (mRNA) levels are elevated in leptin-deficient mice. Fasting associated with a decline in circulating leptin normally causes a 15-fold elevation of hypothalamic Agrp mRNA levels but has no effect in leptin-deficient mice ...
B D, Wilson +6 more
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Melanocortin 1 Receptor: Structure, Function and Regulation
Frontiers in Genetics, 2016 The melanocortin 1 receptor (MC1R) is a melanocytic Gs protein coupled receptor that regulates skin pigmentation, UV responses, and melanoma risk. It is a highly polymorphic gene, and loss of function correlates with a fair, UV-sensitive, and melanoma ...
Erin Marissa Wolf Horrell +2 more
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