Results 11 to 20 of about 17,109 (214)

Agouti signaling protein and other factors modulating differentiation and proliferation of immortal melanoblasts [PDF]

Developmental Dynamics, 2001
AbstractThe melanocyte lineage potentially forms an attractive model system for studies in cell differentiation, developmental genetics, cell signaling, and melanoma, because differentiated cells produce the visible pigment melanin. Immortal lines of murine melanoblasts (melanocyte precursors) have been described previously, but induction of ...
E V, Sviderskaya, S P, Hill, D, Balachandar, G S, Barsh, D C, Bennett   +4 more
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Loop-Swapped Chimeras of the Agouti-Related Protein and the Agouti Signaling Protein Identify Contacts Required for Melanocortin 1 Receptor Selectivity and Antagonism [PDF]

Journal of Molecular Biology, 2010
Agouti-related protein (AgRP) and agouti signaling protein (ASIP) are homologs that play critical roles in energy balance and pigmentation, respectively, by functioning as antagonistic ligands at their cognate melanocortin receptors. Signaling specificity is mediated in part through receptor binding selectivity brought about by alterations in the ...
Mira P, Patel, Camila S, Cribb Fabersunne, Ying-Kui, Yang, Christopher B, Kaelin, Gregory S, Barsh, Glenn L, Millhauser   +5 more
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Chemical disulfide mapping identifies an inhibitor cystine knot in the agouti signaling protein [PDF]

FEBS Letters, 2007
The agouti signaling protein (ASIP) and its homolog, the agouti‐related protein (AgRP), act as inverse agonists that control, respectively, pigmentation and metabolic function in mammals. NMR investigations find that the C‐terminal domains of these proteins adopt a fold consistent with an inhibitor cystine knot (ICK), previously identified in ...
Yu, Bin, Millhauser, Glenn L.
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Agouti Signaling Protein Stimulates Islet Amyloid Polypeptide (Amylin) Secretion in Pancreatic β-Cells

Experimental Biology and Medicine, 2001
Ectopic overexpression of the murine agouti gene results in yellow coat color, obesity, hyperinsulinemia, and type II diabetes. We have shown the human homologue of agouti (agouti signaling protein; ASP) to regulate human adipocyte metabolism and lipid storage via a Ca2+-dependent mechanism.
B, Xue, M B, Zemel
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Agouti-Signalling Protein Overexpression Reduces Aggressiveness in Zebrafish

Biology, 2023
Feeding motivation plays a crucial role in food intake and growth. It closely depends on hunger and satiation, which are controlled by the melanocortin system. Overexpression of the inverse agonist agouti-signalling protein (ASIP) and agouti-related protein (AGRP) leads to enhanced food intake, linear growth, and weight. In zebrafish, overexpression of
Ana Rocha, Alejandra Godino-Gimeno, Josep Rotllant, José Miguel Cerdá-Reverter   +3 more
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Agouti-related protein as the glucose signaling sensor in the central melanocortin circuits in regulating fish food intake

Frontiers in Endocrinology, 2022
Agouti-related protein (AgRP) is a neuropeptide synthesized by AgRP/NPY neurons and transcribed as 132 amino acids in humans and 142 amino acids (AgRP1) in Japanese seabass (Lateolabrax maculatus) fish.
Juan Han, Xiaofang Liang, Yanzhi Guo, Xiaoliang Wu, Ziqi Li, Tiannuo Hong   +5 more
doaj   +1 more source

Role of Hypothalamic Transforming Growth Factor-β (TGF-β)/Smad Signaling in Feeding Regulation in Chickens

The Journal of Poultry Science, 2022
Previous studies in mammalian obesity models have suggested that central transforming growth factor-β (TGF-β) controls the gene expression of appetite-regulating neuropeptides and peripheral energy metabolism.
Takaoki Saneyasu, Miku Ueda, Kanami Nagata, Jiawei Chai, Kazuhisa Honda, Hiroshi Kamisoyama   +5 more
doaj   +1 more source

A central role for C1q/TNF-related protein 13 (CTRP13) in modulating food intake and body weight. [PDF]

, 2013
C1q/TNF-related protein 13 (CTRP13), a hormone secreted by adipose tissue (adipokines), helps regulate glucose metabolism in peripheral tissues. We previously reported that CTRP13 expression is increased in obese and hyperphagic leptin-deficient mice ...
Byerly, Mardi S, McCulloh, Patrick S, Seldin, Marcus M, Swanson, Roy, Wei, Zhikui, Wong, G William   +5 more
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Melanism in peromyscus is caused by independent mutations in agouti. [PDF]

PLoS ONE, 2009
Identifying the molecular basis of phenotypes that have evolved independently can provide insight into the ways genetic and developmental constraints influence the maintenance of phenotypic diversity.
Evan P Kingsley, Marie Manceau, Christopher D Wiley, Hopi E Hoekstra   +3 more
doaj   +1 more source

Physiological and Anatomical Circuitry between Agouti-Related Protein and Leptin Signaling* [PDF]

Endocrinology, 1999
Agouti-related protein (AGRP) is an orexigenic neuropeptide that acts via central melanocortin receptors, and whose messenger RNA (mRNA) levels are elevated in leptin-deficient mice. Fasting associated with a decline in circulating leptin normally causes a 15-fold elevation of hypothalamic Agrp mRNA levels but has no effect in leptin-deficient mice ...
B D, Wilson, D, Bagnol, C B, Kaelin, M M, Ollmann, I, Gantz, S J, Watson, G S, Barsh   +6 more
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