Results 31 to 40 of about 32,179 (263)

Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia [PDF]

, 2017
The antipsychotic clozapine is uniquely effective in the management of schizophrenia; however, its use is limited by its potential to induce agranulocytosis.
Alfirevic, A., Cascorbi, I., Chambert, K. D., Clozapine-Induced Agranulocytosis Consortium, Collier, D. A., Daly, M. J., Daly, M. J., Dettling, M., Duncan, L., Fourches, D., Gazit, E., Genovese, G., Giegling, I., Goff, D. C., Goldstein, J. I., Goldstein, J. I., Hamshere, M. L., Hilliard, C., Holden, A. L., Holmans, P., Huang, H., Jarskog, L. F., Jonasdottir, A., Jorskog, L. F., Josiassen, R. C., Kelly, D. L., Kennedy, J. L., Kirov, G., Legge, S. E., Lek, M., Leonenko, G., Levy, D. L., Lieberman, J. A., MacCabe, J. H., Malhotra, A. K, Mantripragada, K, McCarroll, S. A., Moran, J. L., Neale, B. M., Neale, B. M., Nielsen, J., O'Donovan, M. C., Owen, M. J., Pardinas, A. F., Pirmohamed, M., Rees, E., Richards, A. L., Ripke, S., Ripke, S., Rujescu, D., Rujescu, D., Shianna, K., Stefansson, H., Sullivan, P. F., Sullivan, P. F., Szatkiewicz, J. P., Tropsha, A., van den Oord, E. J. C. G., Walters, J.T. R, Werge, T.   +59 more
core   +1 more source

Antigenicity of chlorpromazine and clozapine to rabbits [PDF]

, 1970
Antigenicity of clozapine was studied in rabbits, comparing with that of chlorpromazine as control. The results indicate that chlorpromazine produces antibody in rabbit as revealed by passive hemagglutination test, giving the titer of 1 : 2, 000 or ...
Seno, Satimaru, Tada, Hiroshi, Ueki, Ayako   +2 more
core   +1 more source

Carbamazepine-induced Life-threatening Stevens-Johnson Syndrome and Agranulocytosis: The Maiden Case [PDF]

Journal of Clinical and Diagnostic Research, 2016
Stevens-Johnson syndrome is one of the few dermatological emergencies in clinical practice. The syndrome is often secondary to the usage of drugs, of which allopurinol, penicillins, sulfa drugs, ibuprofen, sodium valproate, phenytoin, lamotrigine and ...
A. Avinash, V. Mohanbabu Amberkar, Sushil Kiran Kunder, Sharath Madhyastha, K. Meenakumari   +4 more
doaj   +1 more source

A hyperthyreosis kezelésének ritka mellékhatásai [PDF]

, 2016
Absztrakt A szerzők hyperthyreosis miatt gondozott beteg esetét ismertetik, akinél a kezelés során propiltiouracil indukálta vasculitis igazolódott renalis érintettséggel, amely a ...
Gasztonyi, Beáta, Györkös, Andrea, Kovács, Mónika, Sohár, Gábor   +3 more
core   +1 more source

Efficacy and safety of universal valganciclovir prophylaxis combined with a tacrolimus/mycophenolate-based regimen in kidney transplantation. [PDF]

, 2007
BACKGROUND: Immunosuppressive and antiviral prophylactic drugs are needed to prevent acute rejection and infection after transplantation. We assessed the efficacy and safety of the introduction of universal valganciclovir prophylaxis in combination with ...
Fellay, J., Fontana, M., Manuel, O., Matter, M., Meylan, P.R., Pascual, M., Sturzenegger, N., Venetz, J.P., Wasserfallen, J.B.   +8 more
core   +1 more source

Post‐Discharge Opioid Prescribing After Elective Colorectal Resection: An International Survey

World Journal of Surgery, EarlyView.
Excessive opioid prescribing after colorectal surgery can lead to adverse events and contribute to the opioid crisis. Understanding international prescribing patterns is essential for guiding practice and future research. The Analgesia After Colorectal Surgery (ACORE) survey aimed to characterize international opioid prescribing practices after ...
Ghadeer Olleik, Hiba Elhaj, Samin Shirzadi, Francesca Fermi, Maxime Lapointe‐Gagner, Sender Liberman, Mohsen Alhashemi, Tahereh Najafi Ghezeljeh, Fatemeh Rajabiyazdi, Nawar Touma, Pepa Kaneva, Agnihotram V. Ramanakumar, Badma Bashankaev, Alexandra Sidorova, Stephen J. Chapman, Chuan‐Gang Fu, Lucia Oliveira, Sofia Valanci, Audrius Dulskas, Steven Wexner, Lawrence Lee, Liane S. Feldman, Marylise Boutros, Julio F. Fiore Jr.   +23 more
wiley   +1 more source

Considerations of HLA, Renal Failure, Valproic Acid Use, and Current Treatment Guidelines in Clozapine-Induced Agranulocytosis

Case Reports in Psychiatry, 2021
Clozapine, the choice atypical antipsychotic for refractory schizophrenia, schizoaffective disorder, and bipolar disorder, has been shown to reduce positive and negative symptoms of schizophrenia.
Melissa Sussman, Michael Epifania, Derrick Eng, Yun Jae Cho, Richard Steward   +4 more
doaj   +1 more source

Comparative efficacy of deferiprone, deferoxamine and combination of deferiprone and deferoxamine on serum ferritin value in Beta-Thalassemia patients [PDF]

, 2015
Background: Iron overload is a predictable and life-threatening complication in patients with thalassemia. Effective and convenient iron chelation remains one of the main targets of clinical management of thalassemia major.
Amlashi, H.M., Behnampour, N., Jahazi, A., Mirbehbahani, N.   +3 more
core   +1 more source

Oral manifestations and dental management of patient with leukocyte alterations [PDF]

, 2011
Leukocytes are the main cellular elements of inflammatory and immune reactions of the organism. Leukocyte alterations are the consequence of an imbalance between the formation of leukocytes in the bone marrow and its elimination by the mononuclear ...
Gavaldá Esteve, Carmen, Mancheño Franch, Aisha, Sarrión Pérez, María Gracia   +2 more
core   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source