Results 11 to 20 of about 25,024 (199)

Development of Agranulocytosis after Discontinuation of Methimazole: An Unusual Case [PDF]

Case Reports in Endocrinology, 2015
Agranulocytosis is a rare and critical adverse effect of antithyroid drugs (ATD). The occurrence of agranulocytosis in continuous ATD treatment patients is well known; however, a case of ATD agranulocytosis occurring following the discontinuation of ...
Rıfkı Üçler, Murat Atmaca, Ömer Candar, Murat Alay, Burhan Göy, Erdal Kara, Mahfuz Turan, Yusuf Demir   +7 more
doaj   +2 more sources

Ceftriaxone-induced Agranulocytosis [PDF]

European Journal of Case Reports in Internal Medicine, 2021
Ceftriaxone is a widely used antibiotic regarded as safe and effective. Drug-induced agranulocytosis is a life-threatening adverse reaction and few reports related to ceftriaxone were found in a review of the literature.
Lénio Couto, André Goulart, Ivone Valadão, Magda Garça, Maria Beatriz Santos, Pedro Cota, Carolina Teixeira   +6 more
doaj   +2 more sources

Maternal Dipyrone Exposure and Risk of Major Congenital Malformations, Adverse Perinatal and Postnatal Outcomes: A Population-Based Cohort Study. [PDF]

Clin Pharmacol Ther
Pain and fever are common in pregnancy. Dipyrone is widely used in Europe, Latin America, and parts of Asia, but is banned in other countries due to concerns about agranulocytosis. Evidence on its safety in pregnancy remains limited and inconsistent. This study aimed to evaluate whether maternal dipyrone use during the first‐ and third‐trimesters is ...
Shitrit IB, Idan D, Hasidim AA, Michael T, Levy A, Pariente G, Lunenfeld E, Daniel S.   +7 more
europepmc   +2 more sources

Neutropenia, agranulocytosis and dipyrone

São Paulo Medical Journal
CONTEXT: Neutropenia and agranulocytosis may be defined as granulocyte counts of less than 1,500/mm³ and 500/mm³, respectively. Agranulocytosis is a rare and serious disease often caused by drugs. Its mortality rate is around 10%.
Nelson Hamerschlak, Alexandre Biasi Cavalcanti   +1 more
doaj   +2 more sources

Characteristics of Severe and Typical Agranulocytosis Induced by Antithyroid Drugs. [PDF]

Clin Pharmacol Ther
Agranulocytosis is a rare but serious side effect of antithyroid drugs (ATDs), defined by an absolute neutrophil count (ANC) below 500/μL; some patients develop a more severe form with ANC below 100/μL.
Mao L, Cao L, Wu C, Zhu H, Zhang Z, Zhang Z, Liu Y.   +6 more
europepmc   +2 more sources

Association between initial 30-day cumulative clozapine dose and risk of agranulocytosis: A nationwide register-based cohort study. [PDF]

Psychiatry Clin Neurosci
Aims Clozapine‐induced agranulocytosis (CIA) is traditionally considered an idiosyncratic, dose‐independent reaction. However, emerging evidence suggests that clozapine‐related inflammatory events may exhibit dose‐dependent characteristics, leading us to hypothesize that CIA risk may similarly relate to early cumulative exposure.
Kikuchi Y, Li X, Komatsu H, Yasui-Furukori N, Inada K, Tomita H.   +5 more
europepmc   +2 more sources

Asymptomatic Propylthiouracil Induced Agranulocytosis in a Patient with Toxic Nodular Goiter: A Rare Case Report

International Medical Case Reports Journal, 2023
Wongel Tena Shale,1 Keno Mohammed Umer,2 Gutu Ganati Tola,1 Fayera Abetu Guluju1 1Jimma University, College of Public Health and Medical Sciences, Department of Surgery, Jimma, Oromia, Ethiopia; 2Department of General Surgery, Dire Dawa University, Dire ...
Shale WT, Umer KM, Tola GG, Guluju FA
doaj   +1 more source

A Disproportionality Analysis of β-lactam Antibiotic Related Blood and Lymphatic System Disorders Based on the FDA Adverse Event Reporting System Database. [PDF]

Health Sci Rep
ABSTRACT Background and Aims β‐lactam antibiotics stand as the most profoundly impactful classes of antibacterial agents worldwide. Their widespread application has raised safety concerns over adverse events (AEs), such as blood and lymphatic system disorders (BLSDs).
Liu J, Zhang M, Tang Z, Wang X, Mu L, Chen W, Song H.   +6 more
europepmc   +2 more sources

Drug-induced agranulocytosis: Case series [PDF]

Hospital Pharmacology, 2018
Introduction: Agranulocytosis is a life-threatening disorder characterized by disappearance of granulocytes from peripheral blood or decrease of peripheral neutrophil count below 0.5x109 /l. It frequently occurs as idiosyncratic adverse drug reaction. It
Čolović Nataša R., Leković Danijela R., Stojković-Lalošević Milica LJ.   +2 more
doaj   +2 more sources

A Systematic Review and a VigiBase Study of Accidental Clozapine Intoxications in Children and Adolescents [PDF]

Hum Psychopharmacol
ABSTRACT Objectives This study aimed to: (1) systematically review published cases of accidental clozapine poisoning in children and adolescents, and (2) study accidental pediatric clozapine intoxications reported to VigiBase, the global pharmacovigilance database.
Jiménez‐Fernández S, De las Cuevas C, Sanz E, de Leon J.   +3 more
europepmc   +2 more sources