Results 11 to 20 of about 28,792 (217)

Metamizole-induced agranulocytosis from a German intensive care perspective [PDF]

Frontiers in Medicine
Background/objectivesMetamizole (dipyrone) is a non-opioid analgesic and antipyretic widely used in Germany, with prescriptions having increased more than tenfold since 1997.
Laura Hille, Laura Hille, Martin J. Hug, Tobias Wengenmayer, Hanna Hilger, Paul Marc Biever   +5 more
doaj   +2 more sources

Clozapine-related neutropenia and agranulocytosis in Korea: 2025 update for rethinking the role of monitoring system [PDF]

Therapeutic Advances in Psychopharmacology
Background: In February 2025, the FDA ended the mandatory Risk Evaluation and Mitigation Strategy requirements for clozapine. Korea continues mandatory hematologic testing under the Clozapine Patient Monitoring System (CPMS), yet no nationwide updates ...
Nuree Kang, Ji Seon Jang, Sung Woo Joo, Jeong Hoon Lee, Jae Hoon Jeong, Minah Kim, Yong Min Ahn, Jun Soo Kwon, Yong Sik Kim, Jung Sun Lee, Se Hyun Kim   +10 more
doaj   +2 more sources

A systematic review and pharmacovigilance analysis of the risk of agranulocytosis associated with metamizole use [PDF]

Scientific Reports
Metamizole is an analgesic widely used after its introduction but later withdrawn in several countries due to the risk of agranulocytosis. Despite this, it remains frequently used worldwide.
Alessia Zinzi, Mario Gaio, Donatella Ruggiero, Consiglia Riccardi, Cecilia Cagnotta, Ciro Pentella, Annalisa Capuano, Concetta Rafaniello   +7 more
doaj   +2 more sources

Severe agranulocytosis in patient with Graves’ disease on second exposure to carbimazole [PDF]

Endocrinology, Diabetes & Metabolism Case Reports
For half a century, antithyroid drugs (ATDs) have been the first-line treatment for Graves’ disease. ATDs, e.g. carbimazole, are associated with minor and serious adverse effects. These include rash, urticaria, arthralgia, hepatotoxicity, vasculitis, and
Hady M Gad, Ammar W Ashor, Waqar Ahmad, Ahmed Hanafy, Barkavi Dhakshinamoorthy, Wael Elsaify, Simon Ashwell   +6 more
doaj   +2 more sources

Predicting clozapine-induced adverse drug reaction biomarkers using machine learning [PDF]

Scientific Reports
Clozapine is an atypical antipsychotic used for patients with treatment-resistant schizophrenia. This drug has serious adverse drug reactions (ADRs), including the risk of severe neutropenia (agranulocytosis).
John-Paul Cooper, Pierre Chue, Arno G. Siraki, Lusine Tonoyan   +3 more
doaj   +2 more sources

Ceftazidime‐Induced Agranulocytosis: A Case Report [PDF]

Clinical Case Reports
The most common adverse events associated with ceftazidime include hypersensitivity reactions, gastrointestinal disturbances, and transient abnormal liver function tests, whereas neutropenia is a rare complication.
Bingbin Dong, Xin Wu, Changbao Huang
doaj   +2 more sources

Severe Immune Neutropenia Responsive to Ruxolitinib. [PDF]

EJHaem
eJHaem, Volume 7, Issue 2, April 2026.
Schwarzkopf R, Chen AAY, Elsharawi I, O'Reilly T, Chen LYC.   +4 more
europepmc   +2 more sources

Distinctive pattern of neutrophil count change in clozapine-associated, life-threatening agranulocytosis

npj Schizophrenia, 2022
The wider use of clozapine is limited by the risk of agranulocytosis and the associated requirement for monitoring of neutrophil counts. We searched local electronic patient records for cases of agranulocytosis occurring during clozapine treatment during
David Taylor, Kalliopi Vallianatou, Eromona Whiskey, Olubanke Dzahini, James MacCabe   +4 more
doaj   +1 more source

HLA-DQB1 6672G>C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry

Translational Psychiatry, 2021
The atypical antipsychotic clozapine is the only effective medication for treatment-resistant schizophrenia. However, it can also induce serious adverse drug reactions, including agranulocytosis and neutropenia.
Bettina Konte, James T. R. Walters, Dan Rujescu, Sophie E. Legge, Antonio F. Pardiñas, Dan Cohen, Munir Pirmohamed, Jari Tiihonen, Annette M. Hartmann, Jan P. Bogers, Jan van der Weide, Karen van der Weide, Anu Putkonen, Eila Repo-Tiihonen, Tero Hallikainen, Ed Silva, Oddur Ingimarsson, Engilbert Sigurdsson, James L. Kennedy, Patrick F. Sullivan, Marcella Rietschel, Gerome Breen, Hreinn Stefansson, Kari Stefansson, David A. Collier, Michael C. O’Donovan, Ina Giegling   +26 more
doaj   +1 more source

Agranulocytosis induced by metamizole and its management with granulocyte growth factor [PDF]

Vojnosanitetski Pregled, 2005
Drug-induced agranulocytosis was defined as a severe selective neutropenia caused by an unexpected drug reaction. Metamizole was the most common nonopioid analgesic drug associated with agranulocytosis.
Čeleketić Dušica, Trpković Andreja, Cvetković Zorica   +2 more
doaj   +1 more source