Antithyroid drugs and birth defects [PDF]
Thyroid Research, 2020 Antithyroid drugs (ATDs) are preferred for the treatment of hyperthyroidism caused by Graves’ disease in pregnant women. The drugs have been a recognized treatment for decades, and a general risk of side effects is known. For the use of ATDs in pregnancy,
Stine Linding Andersen, Stig Andersen
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Iran J Pharm Res, 2019 The thionamide drugs, i.e. carbimazole and its metabolite methimazole (MMI), and propylthiouracil (PTU) have extensively been used in the management of various forms of hyperthyroidism over the past eight decades. This review aims to summarize different aspects of these outstanding medications.
Abdi H, Amouzegar A, Azizi F.
europepmc +3 more sources
Thyroidectomy versus antithyroid drugs in Graves’ disease: a meta-analysis of randomized controlled trials [PDF]
BMC SurgeryObjective This meta-analysis was developed to compare the clinical outcomes associated with thyroidectomy and antithyroid drug treatment in Graves’ disease patients, with a focus on outcomes including ophthalmopathy onset or progress, the hyperthyroid ...
XiaoGang Zheng +4 more
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An Overview on the Proposed Mechanisms of Antithyroid Drugs-Induced Liver Injury [PDF]
Advanced Pharmaceutical Bulletin, 2015 Drug-induced liver injury (DILI) is a major problem for pharmaceutical industry and drug development. Mechanisms of DILI are many and varied.
Reza Heidari +4 more
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A case of antithyroid drug‐induced agranulocytosis from a second antithyroid drugs (ATD) administration in a relapsed Graves' disease patient who was tolerant to the first ATD treatment [PDF]
Clinical Case Reports, 2018 Key Clinical Message Agranulocytosis is a rare side effect of antithyroid drugs (ATD) that usually develops within the first 3‐6 months after starting treatment.
Hyunsam Kim, Jeongmin Lee, Jeonghoon Ha
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Antithyroid drugs in Graves′ disease: Are we stretching it too far?
Indian Journal of Endocrinology and Metabolism, 2016 Introduction: Early and durable achievement of euthyroid or hypothyroid status with low likelihood of relapse is the key to effective treatment of Graves′ disease (GD).
Muthukrishnan Jayaraman +2 more
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Clinical pharmacology of thyroid and antithyroid drugs [PDF]
Arhiv za farmaciju, 2022 Autoimmune diseases accompanied by the development of hypothyroidism (Hashimoto's thyroiditis) and hyperthyroidism (Graves' disease) are one of the most common disorders of the thyroid gland.
Stepanović-Petrović Radica +1 more
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Effects of methimazole and propylthiouracil exposure during pregnancy on the risk of neonatal congenital malformations: A meta-analysis. [PDF]
PLoS ONE, 2017 The aim of this study was to determine the effect of exposure to different antithyroid drugs during pregnancy on the incidence of neonatal congenital malformations.A meta-analysis was performed to compare the incidence of neonatal congenital ...
Rongjing Song +4 more
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Effects of short-term potassium iodide treatment for thyrotoxicosis due to Graves disease in children and adolescents [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2014 PurposeGraves disease is the most common cause of hyperthyroidism in children. Inorganic iodide has been used in combination with antithyroid drugs for more effective normalization of thyroid hormones in some cases of severe thyrotoxicosis.
Kyung Uk Jeong +2 more
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