Results 31 to 40 of about 21,429 (179)

Feasibility and Safety of Venetoclax for Cytoreduction During Induction Therapy in Newly Diagnosed Acute Promyelocytic Leukemia

European Journal of Haematology, EarlyView.
ABSTRACT Objective This study aimed to evaluate the feasibility and safety of venetoclax as a cytoreductive strategy during induction therapy in newly diagnosed acute promyelocytic leukemia (APL), and to provide an exploratory description of its early efficacy.
Yu Wang, Rong Xiao, Xiaobing Huang, Yi Xiao   +3 more
wiley   +1 more source

Lacosamide-induced sinus node dysfunction followed by severe agranulocytosis

BMC Neurology, 2021
Background Lacosamide (LCM) is the antiepileptic drug approved by the U.S. Food and Drug Administration in 2008 that facilitates slow activation of the voltage-gated sodium channels.
Makoto Shibata, Reona Hoshino, Chisato Shimizu, Masayuki Sato, Natsumi Furuta, Yoshio Ikeda   +5 more
doaj   +1 more source

Safety and Efficacy of Iron Chelators in Patients With Chronic Kidney Disease: A Systematic Review and Meta‐Analysis

Hemodialysis International, EarlyView.
ABSTRACT Background Iron overload in chronic kidney disease contributes to oxidative injury. The role of iron chelators, standard in transfusion‐related overload, remains unclear in chronic kidney disease. Aim To evaluate the efficacy and safety of iron chelators in adults with chronic kidney disease.
Humam Emad Rajha, Richard Shamoon, Ameer Almeshagbeh, Samah Masry, Fadel Alqatati, Baha H. Abuajameia, Abdulqadir J. Nashwan   +6 more
wiley   +1 more source

Predicting clozapine-induced adverse drug reaction biomarkers using machine learning

Scientific Reports
Clozapine is an atypical antipsychotic used for patients with treatment-resistant schizophrenia. This drug has serious adverse drug reactions (ADRs), including the risk of severe neutropenia (agranulocytosis).
John-Paul Cooper, Pierre Chue, Arno G. Siraki, Lusine Tonoyan   +3 more
doaj   +1 more source

Unusual Synchronous Methimazole-Induced Agranulocytosis and Severe Hepatotoxicity in Patient with Hyperthyroidism: A Case Report and Review of the Literature

International Journal of Endocrinology, 2015
Context. To report a patient with hyperthyroidism who developed concurrent occurrence of agranulocytosis and severe hepatotoxicity after taking methimazole (MMI). Case.
Jun Yang, Jun Zhang, Qin Xu, Guo-ping Sheng, Wan-wen Weng, Meng-jie Dong   +5 more
doaj   +1 more source

Annual Research Review: Psychosis in children and adolescents: key updates from the past 2 decades on psychotic disorders, psychotic experiences, and psychosis risk

Journal of Child Psychology and Psychiatry, Volume 66, Issue 4, Page 460-476, April 2025.
Psychosis in children and adolescents has been studied on a spectrum from (common) psychotic experiences to (rare) early‐onset schizophrenia spectrum disorders. This research review looks at the state‐of‐the‐art for research across the psychosis spectrum, from evidence on psychotic experiences in community and clinical samples of children and ...
Ian Kelleher
wiley   +1 more source

Neutropenia, agranulocytosis and dipyrone

São Paulo Medical Journal
CONTEXT: Neutropenia and agranulocytosis may be defined as granulocyte counts of less than 1,500/mm³ and 500/mm³, respectively. Agranulocytosis is a rare and serious disease often caused by drugs. Its mortality rate is around 10%.
Nelson Hamerschlak, Alexandre Biasi Cavalcanti   +1 more
doaj   +1 more source

Agranulocytosis Associated with Topiramate: A Case Report and Review of Published Cases

Case Reports in Hematology, 2018
A 41-year-old female presented to the hospital with sore throat and shortness of breath. She was hypoxic with an oxygen saturation of 87% in room air. Physical examination revealed swollen uvula with exudates.
Saroj Lohani, Niranjan Tachamo, Salik Nazir, Anthony Donato   +3 more
doaj   +1 more source

Considerations of HLA, Renal Failure, Valproic Acid Use, and Current Treatment Guidelines in Clozapine-Induced Agranulocytosis

Case Reports in Psychiatry, 2021
Clozapine, the choice atypical antipsychotic for refractory schizophrenia, schizoaffective disorder, and bipolar disorder, has been shown to reduce positive and negative symptoms of schizophrenia.
Melissa Sussman, Michael Epifania, Derrick Eng, Yun Jae Cho, Richard Steward   +4 more
doaj   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source