Results 81 to 90 of about 52,487 (253)

Clinical Practice Guidelines on the Management of Menopause in Malaysia 2022: A review from a primary care perspective [PDF]

Malaysian Family Physician
Introduction: Clinical practice guidelines (CPGs) are important tools that assist primary care doctors in their daily practice. Menopause is a physiological condition that affects all women, and the latest Malaysian CPG on menopause can provide guidance ...
Wai Khew Lee, Noreen Zhi Min Ooi, Soo Lee Goh   +2 more
doaj   +1 more source

AGREE-II Appraisal of a clinical algorithm for hypotonia assessment

, 2018
Objective: The objective of this study was to systematically appraise the quality of an evidenced-based clinical algorithm for the clinical assessment of hypotonia in children.
Govender, Pragashnie
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

AGREE II appraisals of pediatric clinical practice guidelines: a systematic review

, 2022
The purpose of the study, in general, is to explore the findings of studies published in the scientific or professional literature that have used the Appraisal of Guidelines for Research and Evaluation II (AGREE II) Instrument (https://www.agreetrust.org/
Ivan D. Florez, Yasser S. Amer
core   +2 more sources

Critical Appraisal of the Quality of Clinical Practice Guidelines for Stress Ulcer Prophylaxis. [PDF]

PLoS ONE, 2016
BACKGROUND AND OBJECTIVE:Inappropriate use of stress ulcer prophylaxis (SUP) is common in many hospitals. High-quality clinical practice guidelines (CPGs) produce better patient outcomes and promote cost-effective clinical care.
Zhi-Kang Ye, Ying Liu, Xiang-Li Cui, Li-Hong Liu   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A critical appraisal of acute sore throat guidelines using the AGREE II instrument: a scoping review

, 2023
International audienceBackground: Conflicting international guidelines exist on the management of sore throat by antibiotics. Objectives: To assess with the Appraisal of Guidelines for Research and Evaluation II (AGREE) instrument the quality of ...
Irène Supper, Rémy Boussageon, Boussageon, Rémy, Mathilde François, Jaafari, Nemat, Supper, Irène, François, Mathilde, Johanna Gratadour, Nemat Jaafari, Gratadour, Johanna   +9 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source