Results 31 to 40 of about 4,700,531 (267)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A Tequintavirus bacteriophage SIA3lw isolated from sewage water with antimicrobial potential against antibiotic-resistant Salmonella Infantis

BMC Microbiology
Background Salmonella enterica serovar Infantis has consistently contributed to foodborne illness in recent years. Due to frequent antibiotic resistance challenges amid Salmonella species, promising antimicrobial alternatives, such as lytic ...
Yen-Te Liao, Angela Voelker, Mackenna Chu, Yujie Zhang, Kan-Ju Ho, Leslie A. Harden, Alexandra Salvador, Vivian C.H. Wu   +7 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Characterization of two novel Salmonella phages having biocontrol potential against Salmonella spp. in gastrointestinal conditions

Scientific Reports
Salmonella is a primary enteric pathogen related to the contamination of poultry and other food products in numerous foodborne outbreaks. The continuous emergence of multidrug-resistant bacteria has become a serious issue due to the overuse of ...
Yujie Zhang, Mackenna Chu, Yen-Te Liao, Alexandra Salvador, Vivian C. H. Wu   +4 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Listeria monocytogenes serotype 4b strains demonstrate a fitness advantage over strains of serotypes 1/2a and 4b-v1 on cantaloupe rind and flesh at different temperatures

Microbiology Spectrum
Listeria monocytogenes is a foodborne pathogen implicated in several produce-related outbreaks. In nature, it is saprophytic and is isolated from agricultural areas and surface waters.
Lisa Gorski, Ashley Aviles Noriega, Michelle Qiu Carter   +2 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Improving the Red Color and Fruit Quality of ‘Kent’ Mango Fruit by Pruning and Preharvest Spraying of Prohydrojasmon or Abscisic Acid

Agronomy, 2020
Pre-harvest application of prohydrojasmon (PDJ) or abscisic acid (ABA) induces the red color in fruits that were exposed to sunlight at the orchard. In this large-scale work, we evaluated the effect of two different pruning techniques of ‘Kent’ mango ...
Sudheeran Pradeep Kumar, Dalia Maurer, Oleg Feygenberg, Cliff Love, Noam Alkan   +4 more
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Characterization of a newly isolated Dhillonvirus bacteriophage vB_EcoS-UDS3lw against Escherichia coli O157:H7

BMC Research Notes
Objective The aim of this study is to characterize a new Dhillonvirus bacteriophage that is lytic against E. coli strains, particularly E. coli O157:H7.
Yen-Te Liao, Abigail R. Arellano, Yujie Zhang, Vivian C.H. Wu   +3 more
doaj   +1 more source