Results 151 to 160 of about 9,029 (175)

Computer-Based Strategy for Modeling the Interaction of AGRP and Related Peptide Ligands with the AGRP-Binding Site of Murine Melanocortin Receptors

Current Pharmaceutical Design, 2005
The hypothesis that the interaction of agouti-related protein (AGRP) and the melanocortin-4 receptor (MC4R) modulates feeding behavior in humans has stimulated the synthesis of conformationally constrained peptides, peptoids and small molecules in efforts to identify novel compounds that can potentially be used in the clinical treatment of obesity and ...
Xiang, Wang, Nigel G J, Richards
openaire   +2 more sources

Effect of gonadectomy on AgRP-induced weight gain in rats

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2008
Agouti-related peptide (AgRP), the endogenous antagonist to the melanocortin 3 and 4 receptors, elicits robust hyperphagia and weight gain in rodents when administered directly into the central nervous system. The relative influence of AgRP to cause weight gain in rodents partially depends on the activity level of the melanocortin agonist-producing ...
Sean Z, Goodin, Alicia R, Kiechler, Alicia R, Keichler, Marissa, Smith, Donna, Wendt, April D, Strader   +5 more
openaire   +2 more sources

NPY/AgRP neurons are not essential for feeding responses to glucoprivation

Peptides, 2007
Animals respond to hypoglycemia by eating and by stimulating gluconeogenesis. These responses to glucose deprivation are initiated by glucose-sensing neurons in the brain, but the neural circuits that control feeding behavior are not well established. Neurons in the arcuate region of the hypothalamus that express neuropeptide Y (NPY) and agouti-related
Serge, Luquet, Colin T, Phillips, Richard D, Palmiter   +2 more
openaire   +2 more sources

Agouti Related Protein (AgRP) is Upregulated in Cushing's Syndrome

Experimental and Clinical Endocrinology & Diabetes, 2005
Alpha melanocyte-stimulating hormone (alpha-MSH) is an agonist at the melanocortin 3 (MC3-R) and melanocortin 4 (MC4-R) receptors. Alpha-MSH stimulates corticosterone release from rat and human adrenal cells. Patients with Cushing's syndrome have elevated levels of serum alpha-MSH.
Dhillo, WS, Gardiner, JV, Castle, L, Bewick, GA, Smith, KL, Meeran, K, Todd, JF, Ghatei, MA, Bloom, S. R.   +8 more
openaire   +3 more sources

Agrp, a novel gene implicated in the control of feeding

Expert Opinion on Investigational Drugs, 1998
Rapid progress has recently been made to characterise a new pathway involved in the control of feeding behaviour, referred to as the melanocortinergic pathway. Studies of the obese phenotype of the yellow mouse mutant (Ay) suggested the existence of this feeding circuit for some time, but the precise molecular and biochemical regulation was unclear ...
openaire   +2 more sources

AgRP

2006
openaire   +2 more sources

Agrp-negative arcuate NPY neurons drive feeding under positive energy balance via altering leptin responsiveness in POMC neurons

Cell Metabolism, 2023
Nicola Lee, Chi Kin Ip
exaly  

Melanocortin-3 receptor expression in AgRP neurons is required for normal activation of the neurons in response to energy deficiency

Cell Reports, 2023
Roger Cone
exaly  

Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation

Cell Metabolism, 2023
exaly  

Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron

Cell Metabolism, 2019
Christopher Bradfield, Daniel Levine, Wenyu Huang   +2 more
exaly