Results 141 to 150 of about 9,029 (175)

Opioidergic Regulation of AgRP Neurons

Physiology, 2023
Opioids are generally known to promote hedonic consumption. Although much of the existing evidence is primarily based on studies in mesolimbic pathway, endogenous opioids and their receptors are widely expressed in hypothalamic appetite circuits; however, their role in homeostatic feeding remains unclear.
Deniz Atasoy, Nilufer Sayar Atasoy, Yavuz Yavuz, Connor Laule, Chunyang Dong, Hyojin Kim, Iltan Aklan, Lin Tian   +7 more
openaire   +1 more source

AgRP neurons encode circadian feeding time

Nature Neuroscience, 2023
Food intake follows a predictable daily pattern and synchronizes metabolic rhythms. Neurons expressing agouti-related protein (AgRP) read out physiological energetic state and elicit feeding, but the regulation of these neurons across daily timescales is poorly understood.
Nilufer Sayar-Atasoy, Iltan Aklan, Yavuz Yavuz, Connor Laule, Hyojin Kim, Jacob Rysted, Muhammed Ikbal Alp, Debbie Davis, Bayram Yilmaz, Deniz Atasoy   +9 more
openaire   +2 more sources

The NPY/AgRP neuron and energy homeostasis

International Journal of Obesity, 2001
Kennedy hypothesized nearly 50 y ago that negative feedback regulation of body fat stores involves hormones that circulate in proportion to adiposity and enter the brain, where they exert inhibitory effects on food intake and energy balance. Recent studies implicate leptin and insulin as 'adiposity signals' to the brain that promote negative energy ...
G J, Morton, M W, Schwartz
openaire   +2 more sources

AgRP signalling negatively regulates bone mass

Journal of Neuroendocrinology, 2021
AbstractThe central nervous system is an active and major regulator of bone structure and remodelling. Specifically, signalling within the hypothalamus has been shown to be critical to ensuring that skeletal functions align with whole body metabolic supply and demand. Here, we identify agouti‐related peptide (AgRP), an orexigenic peptide exclusively co‐
Ronaldo F. Enriquez, Nicola J. Lee, Herbert Herzog   +2 more
openaire   +2 more sources

Starving for AGRP

Nature Reviews Neuroscience, 2012
Activation of hypothalamic agouti-related protein (AGRP)-expressing neurons is known to increase food intake in rodents. Here, Atasoy et al., using channel rhodopsin-assisted circuit mapping and pharmacogenetic techniques, showed that activation of inhibitory projections of AGRP neurons to a small population of oxytocin-expressing neurons in the ...
openaire   +1 more source

Neuroendocrine Regulation by the Agouti/Agrp-Melanocortin System

Endocrine Research, 2000
(2000). Neuroendocrine Regulation by the Agouti/Agrp-Melanocortin System. Endocrine Research: Vol. 26, No. 4, pp. 571-571.
G, Barsh, T, Gunn, L, He, B, Wilson, X, Lu, I, Gantz, S, Watson   +6 more
openaire   +2 more sources

Cannabinoids drive feeding through AgRP neurons

Brain Research
The endocannabinoid system regulates energy balance and feeding behavior, primarily through cannabinoid type-1 receptors (CB1Rs). While CB1R activation is known to increase food intake, the role of agouti-related peptide (AgRP) neurons of the arcuate nucleus (ARC) in this process remains unclear.
YILMAZ, BAYRAM, Goren, Habibe, Yavuz, Yavuz   +2 more
openaire   +3 more sources

The Neuroendocrine Circuitry Controlled by POMC, MSH, and AGRP

2011
Obesity is one of the most challenging health problems worldwide. Over the past few decades, our knowledge concerning mechanisms of weight regulation has increased tremendously leading to the identification of the leptin-melanocortin pathway. The filling level of energy stores is signaled to the brain, and the information is integrated by hypothalamic ...
Heike, Biebermann, Peter, Kühnen, Gunnar, Kleinau, Heiko, Krude   +3 more
openaire   +2 more sources

Serum agouti-related protein (AgRP) levels in bipolar disorder: Could AgRP be a state marker for mania?

Psychiatry Research, 2018
Orexigenic and anorexigenic peptides, especially agouti-related protein (AgRP) and leptin, play important roles in the regulation of energy homeostasis in bipolar disorder. AgRP regulates energy metabolism by increasing appetite and decreasing energy expenditure.
Parlak, Naci, Gorgulu, Yasemin, Cinar, Rugul Kose, Sonmez, Mehmet Bulent, Parlak, Ebru   +4 more
openaire   +3 more sources

AgRP, physiological role of an inverse agonist

International Congress Series, 2003
Abstract The melanocortin (MC) system distinguishes itself by the presence of both endogenous agonists—melanocortins as well as endogenous inverse agonists, namely agouti and agouti-related protein (AgRP). The melanocortin system plays an important role in the regulation of pigmentation and body weight.
Roger A.H. Adan, Wouter A.J. Nijenhuis, Martien J.H. Kas   +2 more
openaire   +1 more source