Results 141 to 150 of about 8,978 (173)
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Nature Reviews Neuroscience, 2012
Activation of hypothalamic agouti-related protein (AGRP)-expressing neurons is known to increase food intake in rodents. Here, Atasoy et al., using channel rhodopsin-assisted circuit mapping and pharmacogenetic techniques, showed that activation of inhibitory projections of AGRP neurons to a small population of oxytocin-expressing neurons in the ...
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Activation of hypothalamic agouti-related protein (AGRP)-expressing neurons is known to increase food intake in rodents. Here, Atasoy et al., using channel rhodopsin-assisted circuit mapping and pharmacogenetic techniques, showed that activation of inhibitory projections of AGRP neurons to a small population of oxytocin-expressing neurons in the ...
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Neuroendocrine Regulation by the Agouti/Agrp-Melanocortin System
Endocrine Research, 2000(2000). Neuroendocrine Regulation by the Agouti/Agrp-Melanocortin System. Endocrine Research: Vol. 26, No. 4, pp. 571-571.
G, Barsh +6 more
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Cannabinoids drive feeding through AgRP neurons
Brain ResearchThe endocannabinoid system regulates energy balance and feeding behavior, primarily through cannabinoid type-1 receptors (CB1Rs). While CB1R activation is known to increase food intake, the role of agouti-related peptide (AgRP) neurons of the arcuate nucleus (ARC) in this process remains unclear.
YILMAZ, BAYRAM +2 more
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The Neuroendocrine Circuitry Controlled by POMC, MSH, and AGRP
2011Obesity is one of the most challenging health problems worldwide. Over the past few decades, our knowledge concerning mechanisms of weight regulation has increased tremendously leading to the identification of the leptin-melanocortin pathway. The filling level of energy stores is signaled to the brain, and the information is integrated by hypothalamic ...
Heike, Biebermann +3 more
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Psychiatry Research, 2018
Orexigenic and anorexigenic peptides, especially agouti-related protein (AgRP) and leptin, play important roles in the regulation of energy homeostasis in bipolar disorder. AgRP regulates energy metabolism by increasing appetite and decreasing energy expenditure.
Parlak, Naci +4 more
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Orexigenic and anorexigenic peptides, especially agouti-related protein (AgRP) and leptin, play important roles in the regulation of energy homeostasis in bipolar disorder. AgRP regulates energy metabolism by increasing appetite and decreasing energy expenditure.
Parlak, Naci +4 more
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AgRP, physiological role of an inverse agonist
International Congress Series, 2003Abstract The melanocortin (MC) system distinguishes itself by the presence of both endogenous agonists—melanocortins as well as endogenous inverse agonists, namely agouti and agouti-related protein (AgRP). The melanocortin system plays an important role in the regulation of pigmentation and body weight.
Roger A.H. Adan +2 more
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Effect of gonadectomy on AgRP-induced weight gain in rats
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2008Agouti-related peptide (AgRP), the endogenous antagonist to the melanocortin 3 and 4 receptors, elicits robust hyperphagia and weight gain in rodents when administered directly into the central nervous system. The relative influence of AgRP to cause weight gain in rodents partially depends on the activity level of the melanocortin agonist-producing ...
Sean Z, Goodin +5 more
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Current Pharmaceutical Design, 2005
The hypothesis that the interaction of agouti-related protein (AGRP) and the melanocortin-4 receptor (MC4R) modulates feeding behavior in humans has stimulated the synthesis of conformationally constrained peptides, peptoids and small molecules in efforts to identify novel compounds that can potentially be used in the clinical treatment of obesity and ...
Xiang, Wang, Nigel G J, Richards
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The hypothesis that the interaction of agouti-related protein (AGRP) and the melanocortin-4 receptor (MC4R) modulates feeding behavior in humans has stimulated the synthesis of conformationally constrained peptides, peptoids and small molecules in efforts to identify novel compounds that can potentially be used in the clinical treatment of obesity and ...
Xiang, Wang, Nigel G J, Richards
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Agrp, a novel gene implicated in the control of feeding
Expert Opinion on Investigational Drugs, 1998Rapid progress has recently been made to characterise a new pathway involved in the control of feeding behaviour, referred to as the melanocortinergic pathway. Studies of the obese phenotype of the yellow mouse mutant (Ay) suggested the existence of this feeding circuit for some time, but the precise molecular and biochemical regulation was unclear ...
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NPY/AgRP neurons are not essential for feeding responses to glucoprivation
Peptides, 2007Animals respond to hypoglycemia by eating and by stimulating gluconeogenesis. These responses to glucose deprivation are initiated by glucose-sensing neurons in the brain, but the neural circuits that control feeding behavior are not well established. Neurons in the arcuate region of the hypothalamus that express neuropeptide Y (NPY) and agouti-related
Serge, Luquet +2 more
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